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Showing 1 to 20 of 165 for “"hydroxylation"”.
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Steroid Hydroxylation by Bacteria
Made available in DSpace on 2014-12-09T17:35:11Z (GMT). No. of bitstreams: 1 6503698.pdf: 4898302 bytes, checksum: 2e5d4e8e52da9afded3a65bff0943788 (MD5) Previous issue date: 1964
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Steroid Hydroxylation in Microbial and Adrenal Systems
Made available in DSpace on 2014-12-05T19:37:02Z (GMT). No. of bitstreams: 1 5900551.pdf: 2305700 bytes, checksum: e64c99828c092cc12d3e941b20a1ddcf (MD5) Previous issue date: 1958
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Factors Involved in the N-Hydroxylation of 2-Acetylaminofluorene
Made available in DSpace on 2014-12-09T14:36:54Z (GMT). No. of bitstreams: 1 6607804.pdf: 4021092 bytes, checksum: e85393a25c80ef0f7c204b7a0b60c8f7 (MD5) Previous issue date: 1966
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PHOTOCHEMICAL HYDROXYLATION OF 1-METHYLANTHRAQUINONES: SYNTHESIS OF 9`-HYDROXYALOESAPONARIN II
… reaction was examined by using the photochemical hydroxylation in the first synthesis of a natural product, 9'-hydroxyaloesaponarin II.
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Surface hydroxylation of styrene-butadiene-styrene block copolymers for biomaterials.
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1974.
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Metal-Aluminum Oxide Interactions: Effects of Surface Hydroxylation and High Electric Field
… This research includes: (1) the surface hydroxylation effects on the aluminum oxide interactions with copper adlayers, and (2) effects of high electric fields on the interface of thin aluminum oxide films and Ni3Al substrate. X-ray photoelectron spectroscopy (XPS) studies and first …
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A kinetic and equilibrium description of camphor hydroxylation by the P450cam monoxygenase system
… that an effector m02rs complex precedes camphor hydroxylation. Cytochrome m is shown by equilibrium methods to bind two molecules of putidaredoxin. Pd binding at one site induces a shift in the Soret absorption maximum of cytochrome m corresponding to an observed difference spectrum with peak at …
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Late-stage C(sp3)–H hydroxylation, amination, and methylation in nitrogen-containing molecules
… hand, functionalizations alpha to nitrogen via hydroxylation have been demonstrated, but the hydroxylated intermediates are by nature more hyperconjugatively activated than the substrates and promote overoxidation, thus requiring reduction before further derivatization. In this dissertation, I …
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New horizons of aliphatic C—H amination and hydroxylation reactions with manganese catalysis
… manganese catalysts for C—H amination and C—H hydroxylation reactions with unprecedented amalgamation of high reactivity with strong C—H bonds (2º and even 1º) while maintaining high chemoselectivity for aromatic -functionalities. These new catalysts afford opportunities to fully realize the …
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A Kinetic and Equilibrium Description of Camphor Hydroxylation by the P450(cam) Monoxygenase System
Made available in DSpace on 2015-05-13T15:21:59Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7606964.PDF: 4065498 bytes, checksum: f3a87d1068ecf336ad9cdc4bff7c45e0 (MD5) Previous issue date: 1975
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Studies toward the synthesis of celastrol and the late-stage hydroxylation of arenes mediated by 4,5-dichlorophthaloyl peroxide
… Following our initial report describing the hydroxylation of arenes using phthaloyl peroxide, new peroxide derivatives were investigated to probe their reactivity in an effort to hydroxylate aromatics which were previously unreactive. Electronically poor to moderately rich arenes were …
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Reactor design for the hydroxylation of n-octane using a cyp153a6-based biocatalytic system expressed in Escherichia coli
… conditions. This study focuses on the biological hydroxylation of n-octane to 1-octanol using a previously developed cytochrome P450 monooxygenase, CYP153A6, enzymatic system. The biocatalyst was expressed in Escherichia coli BL21(DE3) by using a pET28b-PFR1500 plasmid encoding the complete operon …
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Dioxygen activation and substrate hydroxylation by the hydroxylase component of toluene/O-xylene monooxygenase from pseudomonas sporium OX1
Non-heme carboxylate-bridged diiron centers in the hydroxylase components of the bacterial multicomponent monooxygenases activate dioxygen at structurally homologous active sites. Catalysis requires the management of four substrates: electrons, protons, dioxygen, and hydrocarbons. Protein component …
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The 21-dehydroxylation of corticosteroids: evidence for an enol intermediate and the hydroxylation of steroids by fungal cyto-chrome P450: evidence for a stepwise mechanism
Two enzyme mechanisms were examined: the 21-dehydroxylation of corticosteroids by the anaerobe Eubacterium l en tum, and the hydroxylation of steroids by fungal cytochrome P450. Deuterium labelling techniques were used to study the enzymic dehydroxylation. Corticosteroids doubly labelled (2H) at …
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Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH
… first found to catalyse the post translational hydroxylation of a family of transcription factors known as Hypoxia Inducible Factors (HIFs), and thus acts as a cellular sensor of hypoxia. Subsequently, other protein substrates were discovered containing ankyrin (ANK) repeat domains, although …
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I. Synthesis of Ascarosides for Chemical Biology Studies in Caenorhabditis elegans, II. A Photochemical Approach to Delavayine, and III. Remote Hydroxylation by Radical Translocation and Polar Crossover
The foci of this dissertation are the synthesis of analogs for chemical biology studies, synthetic chemistry method development (with an emphasis on photochemistry), and the application of these methods toward total synthesis. Chapter 1 outlines the synthesis of an array of pheromone analogs that …
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An investigation into fungal metabolism of halogenated and related steroids
… ~ lunata, the ll-fluoro- substituent prevent hydroxylation at the 11 position, but diverted it to a site remote from the fluorine atom. In contrast, with ~ stolonifer the llB-fluoro- substituent, although slowing the apparent rate of hydroxylation, did not prevent its occurrence at the 11a- …
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Engineering of an efficient and enantioselective biocatalyst for the preparation of chiral pharmaceutical intermediates
… and genetic engineering for the enantioselective hydroxylation of non-activated carbon atom, a useful but challenging reaction for the synthesis of chiral pharmaceutical intermediates. Our target enzyme is the novel P450pyr enzyme from Sphingomonas sp. HXN-200 that was found to catalyze the regio- …
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Vliv cytochromu b5 na enzymovou kinetiku hydroxylace Sudanu I lidským cytochromem P450 1A1
… As a marker reaction for this enzyme can be used hydroxylation of Sudan I, which has previously been widely used as a azo dye in industry, but since 1980s it is banned for coloring food and cosmetics for its negative influence on the organism. NADPH:cytochrome P450 reductase is the major electron …
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I. Biomimetic oxidations using non-heme iron catalysis. II. Palladium- and hypervalent iodine-catalyzed tandem wacker-dehydrogenation of terminal olefins
… directing groups for non-heme iron catalyzed C—H hydroxylation will be described. Examination of substrates for C—H hydroxylation that featured unfavorable electronic, steric, or stereoelectronic effects demonstrated that carboxylic acids were capable of overcoming these substrate biases during …
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