Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"hydroxy acid"”.
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Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma
Background: Hydroxy acid oxidases are flavin mononucleotide (FMN)-dependent peroxisomal enzymes. Although it is unclear whether 2-hydroxy acid oxidases contribute to a general mechanism of fatty acid α-oxidation, these enzymes are capable of oxidizing a broad range of 2-hydroxy acids, ranging from …
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The complexes of palladium (II) and nickel (II) with cycloalkanecarboxylic acid
<p>Although some organic hydroxy acid complexes of palladium(II) and nickel(II) have been described (1-9), crystalline palladium(II) and mickel(II) dicycloalkanecarboxylates have not been reported.</p><p>The interaction of a palladium salt such as NA<sub>2</sub>PdCl<sub>4</sub> or a nickel salt …
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An investigation involving a comparison between the hydrolytic degradation of lovastatin and simvastatin using HPLC
… require metabolic activation to form the active acid forms, namely lovastatin hydroxy acid (LVA) and simvastatin hydroxy acid (SVA). Both statins possess similar chemical structures and the only differences is the presence of a 2-methylbutryloxy side chain moiety for LV compared to SV that …
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… the ribosomal machinery to incorporate a hydroxy acid into the peptide thus generating an ester linkage directly between the lanthipeptide leader and core regions, which is selectively hydrolyzed under mild alkaline conditions. Labeling of natural products with biophysical probes has …
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Poly(α-hydroxyalkanoic acid): Polymerization methodology, materials, and applications
… to expend the chemistry and materials of poly(α-hydroxyalkanoic acids) (PAHAs). In first part of this dissertation (chapter 2), we developed a metal catalyst based method for preparation of well-defined, side-chain and terminal modified poly(α-hydroxyalkanoic acids) from α-hydroxy acid …
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The synthesis and properties of some higher membered fused alicyclic ring systems
… undergoes the normal reaction with nitrous acid to yield derivatives of benz-cyclo-heptane. However, further attempts to apply this reaction to the synthesis of bicyclo-[0.5.5]-dodecane derivatives was abandoned because of the difficulty of preparing the required amino intermediates. The use …
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A metabolomics approach for targeted isolation and production of bioactive secondary metabolites in microbial isolates from extreme environments
… afforded a series of bioactive alpha and beta-hydroxy acid derivatives and allowed the definition of a preliminary structure-activity relationship based on their relative potency. Aseanostatin P6 (13-methyltetradecanoic acid) was the major compound identified, followed by two derivatives, …
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Biochemical and Genetic Characterization of Reduced Phosphorus Metabolism in Pseudomonas Stutzeri WM88
… is a novel member of the D-isomer specific 2-hydroxy-acid enzyme family of dehydrogenases and catalyzes the oxidation of phosphite to phosphate while reducing NAD to NADH. Reporter gene fusions were used to examine the regulation of expression of the htx and ptx operons. Under conditions of …
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Development and characterization of biodegradable microspheres containing selected antimycobacterials.
… protracted dosage regimens. Biodegradable poly-a-hydroxy acid microspheres and microcapsules containing rifampicin (RIF) and isoniazid (INH) respectively have been prepared with the intention of providing high sustained site-specific concentrations to overcome some of the shortcomings of existing …
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The Degradation and Drug Release Mechanisms of Poly(ethylene glycol)-functionalised Poly(L-lactide) Polymers
… rates of already medically established poly(-hydroxy acid) polymers extending their potential for use within temporary structural implants.