Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"hydroxamate"”.
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The Hydroxamate Reaction of Aminoacyl-tRNA Synthetases
… of determining acyl group activation was the hydroxamate assay. The activated amino acids can be trapped as the stable amino acid hydroxamates by carrying out the activation reactions in high concentrations of hydroxylamine. This thesis comprises a study of the hydroxamate reaction of the …
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Comparison of hydroxamate and fatty acid flotation of hematite, A
Includes bibliographical references.
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An Investigation of Copper Recovery from a Sulphide-Oxide Ore with a Mixed Collector System
… mineral-collector behaviours. PAX and hydroxamate form multiple collector layers on malachite and bornite, with malachite and hydroxamate exhibiting the highest adsorption density. The effective pH range of the collectors was pH 8-10 where the collector species, according to equilibrium …
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Characterization of a Catechol-Type Siderophore and the Detection of a Possible Outer Membrane Receptor Protein from <em>Rhizobium leguminosarum</em> strain IARI 312.
… two main classes of siderophores: catechol and hydroxamate. Catechol-type siderophores chelate ferric iron via hydroxyl groups, and hydroxamate-type siderophores chelate ferric iron via a carbonyl group with an adjacent nitrogen. Rhizobia fix atmospheric nitrogen symbiotically in leguminous …
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Mechanistic Studies and Inhibition of N-hydroxylating Monooxygenases
… play and essential role in the biosynthesis of hydroxamate containing siderophores. Siderophores are high affinity iron-chelators composed of catechol and hydroxamate functional groups that are synthesized and secreted by several microorganisms and plants. It has been showed that many NMOs are …
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Influence of Iron Speciation on Redox Cycling and Reactivity With Persistent Organic Contaminants
… organic ligands containing catechol, thiol, and hydroxamate functional groups form FeII-complexes capable of rapidly reducing both N-heterocyclic nitramine explosives and monosubstituted nitrobenzenes. Detailed kinetic investigations show that the reactivity of FeII-organic complexes is …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica Upwelling Dome
… Functional group determination showed that hydroxamate production dominated from 50-150m, while hydroxamate and catechol production is roughly equal in shallower waters. By characterizing the siderophores produced by these isolates and determining the genetic make-up of the population, these …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica upwelling dome
… Functional group determination showed that hydroxamate production dominated from 50-150m, while hydroxamate and catechol production is roughly equal in shallower waters. By characterizing the siderophores produced by these isolates and determining the genetic make-up of the population, these …
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An improved synthesis of the HDAC inhibitor trichostatin A
… apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known naturally-occurring inhibitors …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… of this work was to examine the ability of novel hydroxamate compounds to inhibit the growth of bacterial cells expressing Bla2. In addition to this work, aptamers were investigated as a potential means of future inhibitor design.
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Chemical biology of matrix metalloproteases
… the facile synthesis of various affinity-based hydroxamate probes that enables the generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.
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Biochemical characterization of Aspergillus fumigatus SidA: a flavin-dependent N-hydroxylating enzyme
Ferrichrome is a hydroxamate-containing siderophore produced by the pathogenic fungus Aspergillus fumigatus during infection. This siderophore includes N5-hydroxylated L-ornithine in the peptide backbone that serve as iron chelators. Af SidA is the L-ornithine N5-hydroxylase, which performs the …
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Biochemical Characterization of Thermocrispum agreste TheA: A Flavin-Dependent N-hydroxylating Enzyme
… L-lysine, and small aliphatic diamines. The hydroxamate moiety produced by this reaction is key for the production of siderophores, small chelating compounds that allow survival in iron limiting conditions. NMOs involved in siderophore biosynthesis have been shown to be essential for …
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A SYNTHETIC TMRNA PLATFORM FOR ELUCIDATION OF BACTERIAL PROTEOME REMODELING UNDER STRESS
… with serine starvation induced by serine hydroxamate. In cells lacking RelE, the mRNA interferease toxin that cleaves mRNA in the ribosome A site, we find a dramatic shift away from catalytic protein degradation and distinct, disparate enrichment of ribosomal proteins in the degradome …
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Total Synthesis of Lasionectrin and Synthetic Studies Towards Pestaloxazine A
… Mitsunobu reaction of known alcohol 291 and hydroxamate 311 to give hydroxamic acid 309. However, attempts to effect 1,6-hydrogen abstraction with hydroxamic acid 309 to provide the 1,2-oxazine ring system were unsuccessful.
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Identification and characterization of a matrix metalloproteinase (Pta1-MMP) expressed during Loblolly pine (Pinus taeda) seed development and germination
… and is inhibited by the active site-binding hydroxamate inhibitor GM6001 and EDTA. The Pta1-MMP gene is expressed during embryo development, with transcript levels increasing from proembryo to early cotyledonary stage, then declining during late cotyledonary expansion and maturation drying. …
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Haem and xenosiderophore mediated iron acquisition by sinorhizobium meliloti and pseudomonas aeruginosa
… 2011 biologically significant. Two putative hydroxamate siderophore outer membrane receptors were identified on the S. meliloti 2011 chromosome. Insertional inactivation indicated that FhuA1 and FhuA2 function in the utilisation of ferrichrome and ferrioxamine B respectively. Analysis of the …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… responsible for CD23 ectodomain shedding is a hydroxamate-sensitive metalloproteinase. Through collaboration with the Blobel group, we analyzed various ADAM KO mouse embryonic fibroblasts (MEFs) and found no involvement of ADAMs 8,9,12,15,17,19, and 33 in CD23 shedding, however we did find a …
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Characterisation of the structural motifs Involved in the cleavage and secretion of human angiotensin-converting enzyme
… was not responsive to phorbol ester or the hydroxamate inhibitor (TAPI), however, it was inhibited by EDTA. The aminopeptidase inhibitor bestatin did not inhibit cleavage or alter the cleavage site. Therefore the protease involved in the cleavage of the ACE stalk peptides is likely different …
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Self assembled transmembrane protein polymer conjugates for the generation of nano thin membranes and micro compartments
… largest transmembrane channel proteins, ferric hydroxamate uptake protein component A (FhuA), found in the outer membrane of Escherichia coli (E. coli). The wild type protein and three genetic variants of FhuA were provided by the group of Prof. Schwaneberg in Aachen. The well known thermo …
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