Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"hydrophobic molecules"”.
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Wood cell wall modification with hydrophobic molecules
… that for some species results in an insertion of hydrophobic chemical substances into the cell walls of already dead wood cells, In the first part of this thesis a chemistry to modify wood cell walls was used, which was inspired by the natural process of heartwood formation. Commercially available …
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Effects of Omega-3s and Vitamin E Prophylactic Diets and the Implications of Lipid Transport in Spinal Cord Injury
… body of evidence shows that administration of hydrophobic molecules such as Vitamin E and long-chain omega-3 polyunsaturated fatty acids (ω3PUFAs) are capable of attenuating secondary damage, while promoting functional recovery after SCI. The precise molecular mechanisms coupling ω3PUFAs and …
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Examination of Brain-Fatty Acid Binding Protein Interaction with Hydrophobic Ligands and Micelles
… family function as intracellular transporters of hydrophobic molecules, facilitating both fatty acid and lipid metabolism. FABPs share a common tertiary structure of beta barrel pocket for ligand incorporation with a flexible lid domain. Dysfunction of brain fatty acid binding protein (FABP7) has …
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MULTIFUNCTIONAL SUPRAMOLECULAR DELIVERY SYSTEM FOR ENHANCING TUMOR IMMUNOTHERAPY
… chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). …
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Removal of dissolved organic matter from surface waters by coagulation with trivalent iron
… d were largely unaffected. Acidic and basic molecules were precipitated much more effectively than neutral ones. Both hydrophilic and hydrophobic molecules were selectively removed compared to compounds of intermediate solubility. Two groups of organic halide precursors were identified. …
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Characterization of a novel cellulose biosynthesis inhibitor, CBI28, in Gluconacetobacter xylinus
… biosythesis inhibition, lysed and small hydrophobic molecules were extracted using methanol and Waters Oasis HLB SPE-Paks. Samples were separated and detected using the Ultra Performance Liquid Chromatograph-Mass Spectrometer/Photo Diode Array. Putative mutants were isolated but did not …
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Nanostructured materials for hydrophobic drug delivery
… (BC) and clofazimine (CFZ) are used as model molecules to investigate the physical and chemical processes governing the interactions of hydrophobic molecules with both inorganic (Psi) and organic (NC) nanostructured carriers. Despite the large number of advantages, Psi does not perform well as …
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Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
… 4 subunit), glycolysis (enolase), transport of hydrophobic molecules (lipocalin) and cytoskeletal arrangements (intermediate filaments and a gelsolin-like adseverin). The most parsimonious explanation for these changes in protein expression assumes that C. gigas reduces nitrate to nitrite and …
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The development of chemically engineered pullulan for drug delivery
… modified by the incorporation of various hydrophobic molecules, to produce two types of derivatives (hydrophobically modified carboxymethyl pullulans (HMCMPs), and crosslinked carboxymethyl pullulan). The foregoing modifications were performed in two steps from the parent pullulan. The …
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A role for a predicted E. coli inner membrane lipoprotein in cell envelope integrity
… an additional layer of protection against hydrophobic molecules including antibiotics, contributing to the multidrug resistance crisis. The Gram-negative membrane is composed of phospholipids, glycolipids, and proteins. A large portion of the bacterial cellular proteome is composed of …
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Phonophoresis and topical drug delivery
… on the migration rate of different classes of molecules through agar gel. The derived data suggested that small, relatively hydrophobic molecules are more susceptible to ultrasound-enhanced diffusion through the water-filled channels of the agar gel. The application of heat alone increased drug …
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… feasibility of co-loading of hydrophilic-hydrophobic and hydrophobic-hydrophobic drug combinations in MSN. We found that loading of hydrophobic molecules such as PTX and 17-AAG depends on the polarity of solvent, with less polar solvents improving drug loading. We have successfully …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… microneedle systems to deliver poorly soluble molecules intradermally in a sustained manner.<br/><br/><br/>In this thesis, amphotericin B, a model poorly soluble drug, was formulated using polymeric microneedle systems to achieve localised, long-acting intradermal delivery. Implantable …
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Electrochemical Pretreatment for Microfiltration of Surface Water: Mechanisms of Fouling and Its Control
… was investigated using ATR-FTIR and XPS. Hydrophobic molecules primarily appeared to initiate physically irreversible fouling during untreated raw water MF. Electroflotation pretreatment reduced fouling by decreasing foulants pore penetration and accumulation of hydrophobic, proteinaceous, …
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Directing the self-assembly of short peptide derivatives
… aqueous environment. We demonstrate that these molecules can form metastable hydrogels upon a combination of solvent switching and sonication of the dipeptide solutions. The hydrogels show instantaneous syneresis upon mechanical contact resulting in rapid expulsion of water and collapse into a …
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Effect of Encapsulated Species on Block Copolymer Micelle Self-Assembly
… chains, surrounding solvent, and any additive molecules. Through manipulation of the polymer characteristics, choice of solvent, and addition of guest molecules, the formation of the nano-scale assemblies can be controlled and tuned for many applications, such as cosmetic products, …
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Phase Phenomena of Proteins in Living Matter
… potentials of mean force (PMFs) derived from hydrophobic molecules available for coarse-grained molecular simulations of protein folding and unfolding under hydrostatic pressure. We investigated the two different pressure-dependencies on the desolvation potential in a structure-based protein …
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Synthesis, Characterization, and Evaluation of Amphiphilic Cell-Penetrating Peptides as siRNA Delivery Tools for Cancer Therapy
… tools. We hypothesized that conjugation of hydrophobic molecules to the (HR)n peptide will enhance hydrophobicity, modulate cytotoxicity, and provide an efficient delivery system for siRNA. Therefore, we synthesized peptide conjugates with the sequence X-(R)n-(HR)4, and X-RnH4 (where X was a …
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Preparation, characterisation and modification of porous carbon monolithic materials for chromatographic and electrochemical applications
… Preliminary separations of mixtures of hydrophobic molecules (alkylbenzenes) on a short 5 μm pore sized glassy carbon monolithic column were carried out using a mobile phase of 100% hexane (or pentane), flow rate 0.7 ml/min, UV detection 270 nm. The backpressure for the monolithic phase …
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An investigation into placental protein 14, a modulator of the immune response associated with human reproduction.
… purification scheme consisted of ion exchange, hydrophobic interaction and gel filtration chromatography, and the pure protein obtained was analysed by SDS-PAGE and Western blotting. The results demonstrate that the purification procedure is a suitable method to obtain PP14 in large quantity and …
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