Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"hydrophobic drugs"”.
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Anti-solvent precipitation and subsequent film formation of hydrophobic drugs for drug delivery
… developed by the pharmaceutical industry are hydrophobic in nature, leading to poor water solubility and bioavailability in the gastrointestinal tract. Dissolution is a limiting factor in their in vivo performance, and increasing their dissolution rate is a major challenge. It has been proven …
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Designing a safe dendronised polymeric nanocarrier for hydrophobic drugs or gene delivery in cancer therapy
… in off-target tissues, whereas poor soluble drugs exhibit short half-life in the bloodstream and high overall clearance rate. Amphiphilic block copolymers based on hydrophobic dendrons have shown to be a promising strategy to enhance the solubility of hydrophobic drugs, prolong circulation …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… acid targeted nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that affect the posterior segment. Etoposide (ET) is used for treatment of retinoblastoma and fluocinolone acetonide (FA) is used for treatment …
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Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
… aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, rapamycin were entrapped in the core of polymeric micelles and solubilized. Polymeric amphiphilic molecules (e.g., hydrogenated castor oil – 40 (HCO-40) and Vit. E …
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Formulation strategies in developing an oil-filled capsule for time-delayed release
… controlled release system aimed at delivering hydrophobic drugs in a wholly time-dependent manner. A swellable, rupturable system in which hydrophobic drugs were solubilised in vegetable oils was proposed. Two main components of the system, the swelling agent low-substituted …
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A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
… be mucoadhesive due to its polycationic nature. Hydrophobic lipids, such as glyceryl monooleate (GMO), have also been used as matrix material for sustained drug delivery of both hydrophilic and hydrophobic drugs. GMO forms liquid crystalline cubic phases in excess of water. This unique property …
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REDOX-RESPONSIVE POLYMER DELIVERY SYSTEMS FOR ANTI-CANCER DRUG AND IMAGING
… human killers. Delivery systems for anti-cancer drugs and imaging agents play important roles in cancer treatment and diagnosis. For development of safe and efficient delivery systems, stimuli-responsive polymers which undergo significant physical or chemical properties change in response to …
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The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
… success in the delivery of photodynamic therapy drugs in animal models, and has great potential as a general delivery vector for hydrophobic drugs. A detailed understanding of what physical forces dictate efficacy in the loading, transport, and delivery of non-covalent drugs is required for …
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Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery
… describing the mechanisms by which stent-eluted drugs are distributed within healthy and atherosclerotic vascular models. In the first part of the thesis we investigated the effect of drug physicochemical properties on drug deposition, retention, and distribution in a healthy vascular model. We …
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… associated with the low bioavailability of hydrophobic drugs. In the first part of the current study, nanosuspensions of two of hydrophobic steroid drugs: hydrocortisone and prednisolone were produced. Nanosuspensions were prepared using a bottom-up approach: the anti-solvent precipitation …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… 40(OC-40) as a potential-therapeutics for AMD. Hydrophobic drugs such as curcumin (CUR), celecoxib (CXB), and resveratrol (RSV) were successfully solubilized and entrapped in the core of the nanomicelles. These nanomicellar constructs efficiently utilize their hydrophilic corona and evade the …
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The use of novel poly(allylamine) based amphiphilic polymers for drug delivery.
… the potential of these amphiphilic polymers for hydrophobic drug delivery. Polyallylamine (PAA) was grafted with four different types of hydrophobic pendant groups (Cholesteryl (Ch), (Fmoc), (Dansyl)and (Naphth)). Some amphiphilic polymers were further reacted with methyl orange to form …
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Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery
… solubility and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property relationship characterization of a new series of organo-soluble cellulose omega-carboxyalkanoates for …
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Amphiphilic linear-dendritic block copolymers for drug delivery
… Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. However, there are still challenges in the design of drug delivery vehicles to achieve efficient drug delivery in a site-specific manner. In this thesis, an …
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Design and characterization of multicompartment micelles in aqueous solution
… such structures only offer a single domain (the hydrophobic inner core) for drug entrapment. Whereas multicompartment micelles composed of a water-soluble shell and a segregated hydrophobic core are novel, interesting morphologies for applications in a variety of fields including medicine, …
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Enzyme responsive nanomaterials for cancer applications
… aggregates based on peptide length, hydrophobicity and charge, the enzyme triggered micelle to fibre transition was explored. Following this it was investigated whether the micelles were capable to perform as mobile vehicles for encapsulation and release of hydrophobic drugs. It was …
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Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery
… groups in CMCAB could aid in complexation with hydrophobic drugs with low solubility, forming an amorphous matrix which can increase the effective solubility and, hence, bioavailability of the drug in physiological conditions. An antibacterial drug and two less soluble anti-viral drugs were …
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Polyurethane nanocomposites as potential drug delivery systems
… of PUNCs and the activity of released drugs. Organically modified silicates (OMS) were prepared using OMs with varying alkyl chain length. The resulting OMS were incorporated at various loadings into PU matrices and solvent cast to form PUNCs. Findings revealed that the optimum …
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Nanomaterials for Biological Applications: Drug Delivery and Bio-sensing
… hollow interior is able to load large amount of hydrophobic drugs such as ibuprofen while the mesoporous shell is capable of prolonged drug. In order to simplify the fabrication procedure, a novel in-situ method is developed to coat silica surface with magnetite nanoparticles. By refluxing the …
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