Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"hydrophobic drug"”.
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Nanostructured materials for hydrophobic drug delivery
… several properties that make them promising for drug delivery applications. In this work, Î2-carotene (BC) and clofazimine (CFZ) are used as model molecules to investigate the physical and chemical processes governing the interactions of hydrophobic molecules with both inorganic (Psi) and …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation concentration …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation concentration …
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The use of novel poly(allylamine) based amphiphilic polymers for drug delivery.
… the potential of these amphiphilic polymers for hydrophobic drug delivery. Polyallylamine (PAA) was grafted with four different types of hydrophobic pendant groups (Cholesteryl (Ch), (Fmoc), (Dansyl)and (Naphth)). Some amphiphilic polymers were further reacted with methyl orange to form …
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Poly(LA-co-TMCC)-graft-PEG Self-assembled Polymeric Nanoparticles for Targeted Drug Delivery
… have gained increased popularity for drug delivery as they not only overcome the problem of limited aqueous solubility of many hydrophobic drug molecules, but also have the potential to improve the pharmacologic properties of anticancer drugs by increasing their in vivo half-life. A …
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Effervescent proliposomes for aerosol delivery to paranasal sinuses
… were found to influence liposome size and drug entrapment of the hydrophobic drug Beclometasone dipropionate (BDP). Mannitol-based formulations developed with DPPC:Chol (1:1) produced liposomes of 7.54±0.15 µm with a drug entrapment efficiency of 82.15±8.29%. Addition of the mucoadhesives …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
Increasing emergence of drugs with poor solubility poses significant challenges for the pharmaceutical industry. A variety of techniques can be used to help improve the solubility profile of these difficult-to-deliver compounds. Intradermal delivery of poorly soluble drugs involves the delivery of …
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
… (MN) arrays to transdermally deliver TB drugs, namely rifampicin, isoniazid, pyrazinamide and ethambutol, which have different physicochemical properties. These drugs were individually prepared into three types of drug reservoirs, including lyophilised tablets, directly compressed tablets …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
<p>Peptide-drug conjugates (PDCs) have emerging applications in the safer delivery of chemotherapeutics to the site of diseases to avoid the side effects associated with the drug. PDCs also improve the physicochemical property of the anticancer drug. Therefore, we have designed and synthesized …
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Self-assembled Polymeric Nanoparticles for Targeted Delivery of Anticancer Drugs
Targeted delivery of drugs to specific regions of the body, or even to specific regions of the cell, promises enhanced drug efficacy and reduced systemic toxicity. By covalently coupling targeting ligands, the smart drug delivery systems are capable of targeting specific cell types exclusively …
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New Applications for Poly(ethylene-alt-maleic anhydride)
… polymer is reacted with a series of different hydrophobic and hydrophilic amines in order to create a series of polymers which allowed the mechanism of ice re-crystallisation to be probed. The findings show that hydrophobic volume appears to play an important role in the mechanism of ice …
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Zirconium-based metal-organic frameworks as drug delivery systems
… to understand and develop the Zr-based MOFs as a drug delivery system. Firstly, a Zr-based MOF, NU-1000, was examined for its ability to encapsulate and deliver a large hydrophobic drug, fulvestrant, in breast cancer cells. NU-1000 was shown to be internalised by the human breast cancer cell line, …
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Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
… basket-shaped cyclotetramer O could be used for drug delivery. Its inner cavity is suitable for encapsulating hydrophobic drug molecules. In part II, it involved in the synthesis and characterization of well-defined π-conjugated arylene ethynylene oligomers. These oligomers have applications in …
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Proliposome and Prosurfactosome Formulations for Pulmonary Drug Delivery
… vesicles (surfactosomes) using the hydrophilic drug salbutamol sulphate (SBS) and the hydrophobic drug beclometasone dipropionate (BDP) for pulmonary delivery via nebulisation. Initially liposomes and surfactosomes with or without cholesterol were prepared using thin film method and were …
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Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
… PCs more than PLA2-GIIA as a typical example. Drug-loaded liposomal membranes could be impaired by sPLA2, triggering drug release at the site of sPLA2 expression. This class of enzymes is therefore an interesting target for developing drug delivery systems for diseases where PLA2s are …
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Surface Modified Solid Lipid Curcumin Nanoparticles For Oral Delivery
… oral bioavailability of several poorly soluble drugs. The objective of the present research was to develop and characterize solid lipid nanoparticles for oral delivery of curcumin using GMO/chitosan based nanoparticulate system containing two different stabilizers. |The oil/water nanoemulsions …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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Nanotechnology in pulmonary drug delivery: Compressible proliposome formulations for nebulization
… are promising carriers for the encapsulation of drug molecules and subsequent delivery to the respiratory tract. The advantages of liposomes as carriers have been widely reported in literature, there are however associated disadvantages such as stability issues when suspended in aqueous media. …
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… on Mesoporous Silica Nanoparticles (MSN) for drug/drug combination therapies. The objective of my dissertation was to optimize surface functionality, particle shape and methods of colloidal stabilization of mesoporous silica by PEG for delivery of drug/drug combinations. This was achieved by …
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