Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"hydrogel-forming"”.
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New hydrogel forming thermo-responsive block copolymers of increasing structural complexity
… of their self-assembly into “smart” hydrogels. In particular the hydrogels were designed to swell at low temperature and could be reversibly switched to a collapsed hydrophobic state by rising the temperature. Starting from two constituents, a short permanently hydrophobic polystyrene …
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Development of dissolving and hydrogel-forming microneedles for delivery of vancomycin hydrochloride
… to investigate the development of dissolving and hydrogel-forming MN for the facilitated delivery of vancomycin hydrochloride (VCL). VCL was formulated into dissolving MN (DMN), in combination with a variety of different excipients. In an alternate approach, VCL reservoirs, namely film dosage …
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Transdermal delivery of heavy chain only antibody binding domains using hydrogel-forming microarray patches
… of both VNARs and Nanobody® molecules using hydrogel-forming microarray patches (MAPs). Using this MAP technology, both HCAbs could permeate through dermatomed (350 µm) neonatal porcine skin in vitro. Furthermore, two Nanobody® molecules were successfully delivered in a Sprague Dawley rat …
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Towards a more efficacious treatment for Oropharyngeal Candidiasis (OPC): Hydrogel-forming tablets for the controlled release delivery of Chlorhexidine diacetate
… by the treatment Finally, a mucoadhesive hydrogel buccal tablets for the controlled release of CHD were designed and prepared to increase the residence time of an effective concentration of CHD in the oral cavity for two hours. They were prepared using Poloxamer 407 (P407), hydroxypropyl …
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
… this thesis described a novel approach, using hydrogel-forming microneedle (MN) arrays to transdermally deliver TB drugs, namely rifampicin, isoniazid, pyrazinamide and ethambutol, which have different physicochemical properties. These drugs were individually prepared into three types of drug …
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Polymeric microneedle systems for enhanced transdermal drug delivery
… the large protein ovalbumin (OVA). A range of hydrogel forming materials for MN production was evaluated to identify the most suitable super swelling hydrogel MN array that are hard in the dry state but, upon insertion into skin, rapidly take up interstitial fluid. The MN themselves contain no …
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Optimisation of microneedle array design for microneedle mediated iontophoretic transdermal drug delivery
… vinyl ether co maleic acid) (PMVE/MA). Novel hydrogel forming MN arrays were fabricated from aqueous blends containing 15% w/w PMVEIMA and 7.5% w/w poly(ethyleneglycol) (PEG, Mw = 10 kDa). MN arrays were fabricated in a laser-engineered micro-moulding process. Hydrogel MN arrays were …
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Microneedle array patches for skin hyperthermia and enhanced intradermal drug delivery
… the dermis. GnRs were synthesized and loaded in hydrogels made from aqueous blends containing poly(methyl vinyl ether-co-maleic acid) and poly(ethylene glycol). These polymeric blends were used to fabricate films to heat up a thin skin model upon Near Infrared (NIR) laser irradiation. This …
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Developing a clinically applicable hydrogel for the treatment of liver disease
… within the hepatocyte niche and develop a novel hydrogel that can replace Matrigel in the three-dimensional differentiation of liver tissue from pluripotent stem cells for liver tissue engineering. The secondary objective was to explore its potential for clinical translation in murine models of …
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The Life of Prion: an investigation into the physiological role of a prion-like protein in the nematode Caenorhabditis elegans
… by a slow FRAP recovery, indicative of a more hydrogel-like structure. To further investigate this, we extracted hydrogel-forming proteins from N2 animals using a biotinylated isoxazole precipitation, identifying a number of novel proteins that may be involved with in the formation of such …
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
… for their utility as injectable in situ hydrogel forming depot for controlled ocular delivery of macromolecules (proteins, peptides and Fab fragments). A wide variety of macromolecules (Octreotide, IgG-Fab, IgG-Fab‘ and IgG) with molecular weights ranging from 1 - 150 kDa have been used …