Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"hydrochlorothiazide"”.
-
Genetic Predictors of Hyperglycemia Due to Hydrochlorothiazide Therapy
… effects on the adverse metabolic effects to hydrochlorothiazide treatment and 2) larger sample sizes are needed for pharmacogenetic studies of inter-individual variation in response to commonly prescribed medication.<strong></strong></p>
-
Clinical pharmacological studies on the interaction between non-steroidal anti-inflammatory drugs and hydrochlorothiazide
Contains fulltext : mmubn000001_028596382.pdf (Publisher’s version ) (Open Access)
-
Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
… widely used antihypertensive drugs, atenolol and hydrochlorothiazide that are cleared predominantly by the kidney but the molecular mechanisms involved in its renal secretion are virtually unknown. Using a panel of HEK cell lines stably expressing major renal drug transporters and absolute …
-
Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
… possessing poor thermal stability. To that end, hydrochlorothiazide and meloxicam were used as model compounds, both selected by their distinguishing properties; exhibiting poor solubility with high melting points and thermal lability. Hydrochlorothiazide was prepared in cocrystal and coamorphous …
-
Genetic Predictors of Metabolic Side Effects of Diuretic Therapy
… effects of genes in the HEME pathway influencing hydrochlorothiazide-induced renal potassium loss.</p> <p>The main goal of this research was to explore first steps in developing hydrochlorothiazide personalize medicine in order to provide a lasting and positive impact on public health. …
-
Modeling Uric Acid Kidney Stones Disease in D. melanogaster using RNAi and Dietary Modulation
… in our model. We found that methotrexate, hydrochlorothiazide, and l-lysine were effective at reducing uric acid kidney stone formation. Lastly, we ran a medium throughput screen of 117 natural compounds for inhibitors of uric acid kidney stone formation using our model and found seven …
-
The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… more women (72.0%) and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with …
-
The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… more women (72.0%) and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with …
-
The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… more women (72.0%) and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with …
-
The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… more women (72.0%) and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with …
-
Renal Toxicity Warnings and Precautions of Drugs Marketed in the US
… of September 1, 2022. Metformin hydrochloride, hydrochlorothiazide, dextrose, potassium chloride, and amlodipine besylate were the drugs with the highest number of renal warnings and precautions. The greatest number of renal warnings occurred in the 2000-2019 decade. There were 85 drugs, …
-
Effect of Encapsulated Species on Block Copolymer Micelle Self-Assembly
… increases in micelle size. The effect of hydrochlorothiazide (HCT), a commercial diuretic, on the micelle structural parameters was explored. For micelles near both the critical micelle concentration and temperature, the presence of HCT induced micellization. At higher polymer …
-
Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
… drugs with renal mechanisms, such as hydrochlorothiazide and amiloride. Conclusion CYP3A5 rs776746T>C, NOS3 rs3918188C>A, ADRB1 rs1801252A>G and NEDD4L rs4149601G>A may be variants of pharmacogenomics importance in Africans with respect to response to hypertension treatment. They seem …