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Showing 1 to 20 of 31 for “"hydroamination"”.
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Amidate complexes of the group 4 metals : sythesis, reactivity, and hydroamination catalysis
… metathesis products. Catalytic aminoalkene cyclohydroamination has also been realized with these complexes, generating N-heterocyclic products. A series of kinetic and labeling studies support an imido-cycloaddition mechanism for catalytic cyclohydroamination of primary aminoalkenes with neutral …
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Copper-catalyzed carbon-heteroatom bond formations : asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction
… bond formations, including asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction. The first part of this dissertation focuses on the development of copper-catalyzed asymmetric hydroamination reactions to access various classes of enantioenriched amines. This …
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The Application of the Titanium-Catalyzed Hydroamination of Alkynes toward the Synthesis of Benzylisoquinoline Derivatives
… 124 was obtained by intramolecular hydroamination of the aminoalkyne 123. Employing Noyori´s reduction protocol, the absolute configuration at C-1 of the benzylisoquinoline was introduced with 93% ee. Finally, methylation of norlaudanosine (146) by a reductive amination protocol …
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The development of a rhodium-catalyzed chemo- and stereoselective hydroamination for the synthesis of 1,2-diamines
… could coordinate to a metal center and allow a hydroamination reaction to occur. Hydroamination was seen as a beneficial strategy to synthesize 1,2-diamines as olefins and amines are reacted in an atom-economical fashion. Initial reaction discovery of the rhodium-catalyzed intermolecular …
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I. Total synthesis of sesquiterpene-tropolones II. Dearomative hydroamination and application to the synthesis of aminoglycosides
The student, Chad Ungarean, accepted the attached license on 2020-12-01 at 04:52.
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Hydroamination of terminal allylic imines, allylic amines, and internal and terminal homoallylic amines: Regioselective and regiodivergent transformations
… advance in organic synthesis. The intermolecular hydroamination of alkenes and amines represents a novel approach towards these disconnections from readily accessible functional groups. This transformation can streamline the synthesis of complex molecules and often allows access to two …
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New Pd and Cu-based catalysts for carbon-heteroatom bond formation
… mediated formation of carbon-nitrogen bonds via hydroamination of olefins. Part I. Chapter 1. Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids Using a biaryl phosphine ligand platform, the first palladium-catalyzed cross-coupling reaction of phenyl chlorosulfate with arylboronic acids …
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Developments and applications of methods for palladium- and copper-catalyzed carbon-nitrogen bond formation
… of copper-hydride (CuH) catalyzed asymmetric hydroamination for the formation of a-chiral carbon(sp³)-nitrogen bonds from olefins. This work includes the application of CuH catalysis to the synthesis of chiral N-alkyl aziridines (Chapter 2), and the discovery and development of novel …
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The development of directing group enabled hydroamination strategies to access to 1,2-, 1,3-, and 1,4- diamines with high levels of regio-, chemo-, and stereoselectivity
… chosen to approach this from the vantage of a hydroamination reaction of olefins, as olefins and amines are both readily accessible. This reaction has the potential to be entirely atom-economical, as well as modular. Another advantage, and concomitant challenge, that comes with this strategy, …
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Gold(I) and Platinum(II)-Catalyzed Hydrofunctionalization of Allenes and Alkenes with Carbon and Nitrogen Nucleophiles
… complexes catalyzed the intermolecular hydroamination of monosubstituted allenes with secondary alkylamines in good yield with selective formation of (<italic>E</italic>)-allylic amines. The scope of the protocol included aryl and alkyl monosubstituted allenes as well as a variety of …
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Investigation of the Steric and Electronic Properties of 3-Iminophosphine Ligands in Chelated Palladium Allyl Complexes for Use in the Regioselective Hydroamination of Allenes
… in this series to regioselectively catalyze the hydroamination of 3-methyl-1,2-butadiene with aryl amines to form solely the kinetic product at room temperature was studied by observing conversion to products via NMR spectroscopy. An understanding of the importance of these 3-iminophosphine …
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Mechanistic Elucidation of M-PR2NRʹ2 Catalysts for Hydrofunctionalization and Cross Coupling Reactions
… hydrofunctionalization reactions, including hydroamination and hydroalkoxylation, were previously catalyzed with [Ru(Cp/Cp*)(PR2NRʹ2)(MeCN)]PF6 catalysts. However, validation of the proposed mechanistic pathway for these complexes has not yet been realized. Investigation of these catalysts …
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Exploiting cooperative effects in s-Block organometallics for new applications in synthesis and catalysis
… in catalysis, in particular intermolecular hydroamination processes; as well as other key stoichiometric transformations, namely deprotonative metallation and C-F bond activation.Group 1 alkyl compounds MCH2SiMe3 (M = Li, Na or K) have proved to be efficient catalysts for intermolecular …
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Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions
… highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. …
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Transition metal-catalyzed olefin functionalization for highly regio-, enantio-, and chemoselective C–X bond formation
… In chapter 2, initial studies on an asymmetric hydroamination method for the highly enantioselective formation of a chiral 1,2-diamine are discussed. To our delight, we have identified a MeO-BIPHEP-type ligand that promotes the hydroamination of allyl amines in moderate yield with excellent …
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COMPLEXES OF GROUP 10 METALS WITH NON-CLASSICAL AND THIOETHER-FUNCTIONALIZED N-HETEROCYCLIC CARBENE LIGANDS
… Sonogashira cross-couplings, and the hydroamination of alkynes. The forth part describes the synthesis of thioether-functionalized NHC precursors, and the coordination chemistry of these NHCs with platinum(II), palladium(II) and nickel(II), and the catalytic activities of these …
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Early Transition Metal CCC-NHC Pincer Complexes: Synthesis, Characterization, and Catalysis
… carbine complex. Catalytic results in hydroamination/cyclization with the Ti complexes and oxidative amination using the Ta complexes will also be reported.
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Copper-catalyzed enantioselective stereodivergent synthesis of amino alcohols
… copper hydride-catalyzed hydrosilylation and hydroamination of readily available enals and enones. This strategy provides a route to all possible stereoisomers of these amino alcohol products, which contain up to three contiguous stereocenters. Catalyst control and stereospecificity were …
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Hydro-amination of low alcohols
… and citric acids, glycerol and some antibiotics; Hydroamination of low alcohols (C2-C4) over Co/Si02 catalysts yielding amines, has been selected as an option to add value to these materials. This process involves reaction of alcohol with ammonia at temperatures ranging from 150 to 210°C and …
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Novel N-heterocyclic activations mediated by magnesium reagents having sterically hindered ligands
… activation and catalytic application in hydroamination reactions of organic heterocumulenes. Firstly, a series of novel sodium magnesiates bearing the sterically demanding bis(amido)silyl ligand {Ph2Si(NAr*)2}2- (Ar*= 2,6-i-Pr2-C6H3) has been prepared. Thus alkyl derivatives …
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