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Showing 1 to 7 of 7 for “"hydroalkylation"”.
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Modular Synthesis and Hydroalkylation of Vicinally Functionalized Ketopiperazines: A solution to the Piperazine Problem
… piperazines. The success of a novel enolate hydroalkylation methodology hinges on a cascade reaction triggered by the addition of allyl magnesium bromide to a vicinally functionalized piperazinonate. Furthermore, we have successfully synthesized fluorinated ketopiperazine, in hopes of …
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Novel palladium precatalysts and their application in cross- coupling reactions and copper-catalyzed enantioselective ring formation
… reactions. Chapter 4. The intramolecular hydroalkylation of di- and trisubstituted alkenes bearing a pendant alkyl bromide to form stereodefined (hetero)carbocycles is reported. The system is highly regio- and stereoselective and employs a Cu-DTBM-SEGPHOS catalyst and …
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Reductive Alkylation Reactions Using Tetramethyldisiloxane and Potassium Tert-Butoxide Via Reductive-Radical Polar Crossover
… the formation of C(sp3)-C(sp3) bonds: the hydroalkylation of vinylarenes (chapter 2), and the cross-electrophile coupling of alkyl halides (chapter 3). This simple system of commonly available reagents is suspected to form a hypercoordinate silicon complex capable of acting as a …
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I. Development of three-component alkene carboamination reactions II. Palladium-catalyzed anti-Markovnikov oxidative amination of alkenes III. Chloroform as a carbon monoxide precursor: in or ex situ generation of co for pd-catalyzed carbonylations IV. Hydroalkylation of alkenes via photoredox catalysis
… cesium hydroxide as a base. Finally, the hydroalkylation of alkenes utilizing a photocatalyst has been achieved. Soft organometallic species and carboxylic acids serve as shelf-stable alkyl fragments and can be appended to vinylarenes through a radical mechanism. The functional group …
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Cascade Annulation and Ring-Opening Reactions of Castagnoli-Cushman-Derived Allylic and Benzylic Thiomorpholinonates
… and concomitant regioselective intramolecular hydroalkylation is described. The method hinges on the <em>in-situ</em> generation of a transient [4.1.0] bicycle, which undergoes selective C˗C bond cleavage to afford sulfur-bearing cross-conjugated dienes. Post-diversification of this versatile …
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The Development of Palladium and Cobalt-Catalyzed Methods for the Syntheses of alpha-Trifluoromethyl and Alkyl Amines
… homoallylic amines via a catalytic hydroalkylation of dienes as well as 3) the enantioselective synthesis of alkyl amines enabled by a 5,6- hydroalkynylation of substituted 2-azatrienes.</p>
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Development and Evolution of ‘Ene’-Reductases for Selective Radical Chemistry
… over the carbon-carbon bond forming event in the hydroalkylation of olefins with dichloroacetamides. This mode of stereocontrol is otherwise inaccessible to these enzymes, but through modification of residues in the enzyme active site, we have developed a catalyst for the highly asymmetric …