Global ETD Search
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Showing 1 to 20 of 30 for “"hydride transfer"”.
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
… pH 6.6. These results are most consistent with a hydride transfer mechanism. The kinetics of oxidation of a peptide substrate by human lysine specific demethylase (LSD1) were also studied. The kcat/KM pH-profile is bell-shaped, indicating the need for one unprotonated nitrogen next to the site of …
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Part I: Development of New Methods for Application in Multicatalytic Reactions Part II: Investigation of Stable Carbenium Catalysts as Hydride Transfer Agents
… revealed the formation of a stable acylpalladium hydride intermediate that could be manipulated in situ allowing for the formation of other functionality. These methods were shown to be compatible in multi-transformation processes leading to the synthesis of complex heterocyclic products in a …
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Kinetics and specificity of nicotinamide nucleotide binding to the dIII component of transhydrogenase from Rhodospirillum Rubrum
… whilst undergoing its redox reaction, in which hydride ion equivalents are transferred from NADH to NADP+ producing NAD+ and NADPH. Transhydrogenase comprises three components; dI binds NA(H), dIII binds NADP(H) and dII spans the membrane. Transhydrogenase is thought to function by way of a …
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Zeolite deactivation during hydrocarbon reactions: characterisation of coke precursors and acidity, product distribution
… of 1-pentene over USHY zeolite, cracking and hydride transfer were the predominant reactions in initial stage which deactivated rapidly allowing isomerisation to become the main reaction afterwards. Deactivation studies showed that coke formation was very strong initially which is in good …
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Iridium Complexes for Intracellular Transfer Hydrogenation and Their Potential Biological Applications
Transfer hydrogenation is a transformation that has been studied for over 100 years and used widely in chemical synthesis. Although transfer hydrogenation can be performed by natural enzymes such as dehydrogenases, small-molecule intracellular metal catalysts (SIMCats) that are capable of …
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Structural studies of Butirosin D and FrbG
… near the N5 of the FAD isoalloxazine, poised for hydride transfer. A comparison with previously determined structures of FMOs in the post-hydride transfer conformation highlights structural rearrangements that may occur following the reduction of the flavin.
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Metal complexes with ligand-tethered organo-hydride donor groups - new prospects for efficient multi-electron reduction
… which bind, and thus activate substrates to hydride transfer from nature s organo-hydride donor (OHD), NADPH, set out to explore the potential of metal complexes with a ligand-tethered OHD or OHD conjugate cation group as new, efficient and green catalysts for the reduction of unsaturated …
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Dissecting the reaction mechanism of sheep liver 6-phosphogluconate dehydrogenase.
… process, while N187 facilitates the hydride transfer step.
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Mechanistic studies to determine the catalytic roles of active site residues in phosphite dehydrogenase
… mechanism of the reaction resembles a phosphoryl transfer reaction. A nucleophilic displacement reaction occurs on the phosphoryl group, with water or hydroxide attacking the phosphorus atom and hydride acting as the leaving group. Given the inherently poor nature of the hydride leaving group, …
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Characterizing Conformational Dynamics and Catalytic Activity of Enzymes by Hydrogen-Deuterium Exchange Mass Spectrometry
… (YADH), responsible for facilitating the hydride transfer to NAD+ for energy production in prokaryotes. In the catalysis of both antibiotics and NAD+ reduction the specific residues involved in each binding mode remain under debate. By using a microfluidics workflow and an adjustable …
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Catalyst and substrate effects in enantioselective C–H insertion reactions of α-diazosulfones
… were C–H insertion and cyclopropanation, with hydride transfer competing in certain instances. Significantly, up to 98% ee has been achieved in the C–H insertion processes using copper-NaBARF-bisoxazoline catalysts, with the presence of the additive NaBARF critical to the efficiency of the …
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A Computational Investigation of the Mechanism of CB1954 Reduction by E.coli Nitroreductase
… as to identify the order of electron and proton transfers, and source of the protons, that make up the initial reduction step. Additionally, molecular mechanics and molecular dynamics have been used to examine the nature of the active site of the wild-type enzyme, as well as several mutants, and …
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Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
… a model of the Michaelis complex formed during hydride transfer. Sedimentation velocity shows that PYCR1 forms a concentration-dependent decamer in solution, consistent with the pentamer-of-dimers assembly seen crystallographically. Kinetic and mutational analysis confirmed several features seen …
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Mechanistic studies on chorismate mutase-prephenate dehydrogenase from E. coli
… His197 may be the catalytic base involved in the hydride transfer from prephenate to NAD + . We have identified three positively charged residues, Lys178, Arg286 and Arg294, that are conserved amongst prephenate dehydrogenases from different organisms. We conducted site-directed mutagenesis on …
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Osmium complexes as models for CO reduction intermediates
… (PPh3)2, has allowed the direct observation of hydride transfer from metal to CSe ligand. These latter results are discussed in Chapter 4.
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Zeolites for Cleaner Processes: Alkylation of isobutane and n-butene
… an inert carrier stream, with no external mass transfer resistance, and with a negligible thermal effect. The results of this study suggest that higher alkylate yield and longer zeolite activity are achieved by increasing the intrinsic hydride transfer rate and the ratio of isobutane to …
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Investigation of catalyst effects in enantioselective copper- and rhodium-mediated transformations of α-diazocarbonyl compounds
… competing reaction pathways involving hydride transfer are observed. Chapter three reports the extension of the catalyst-additive systems, developed for C–H insertions with α-diazo-β-keto sulfones in chapter two, to C–H insertion in analogous α-diazo-β-keto phosphonate and …
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Theoretical Studies of Structures and Mechanisms in Organometallic and Bioinorganic Chemistry: Heck Reaction with Palladium Phosphines, Active Sites of Superoxide Reductase and Cytochrome P450 Monooxygenase, and Tetrairon Hexathiolate Hydrogenase Model
… C6H5Br, migratory insertion of C6H5 to C2H4, b-hydride transfer/olefin elimination of styrene product, and catalyst regeneration by removal of HBr. For the oxidative addition, the rate-determining step, the reaction through monophosphinopalladium complex is more favorable than that through …
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