Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"hybrid peptide"”.
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
… are remarkable sources of novel bioactive peptides. Among these, the antimicrobial peptides (AMPs) have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer a prospect of solving specific target driven antibiotic-resistance. …
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HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition
… coil that is the target of promising antiviral peptides and small molecules. A previously unstudied region of N-terminal trimer was stabilized by fusion to a trimeric scaffold peptide and biophysically characterized (Chapter 2). This hybrid peptide itself potently inhibited HIV fusion, and the …
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CARATTERIZZAZIONE FARMACOLOGICA E FUNZIONALE DI NUOVI LIGANDI DEI RECETTORI COLINERGICI NICOTINICI NEURONALI CHE MODULANO IL RILASCIO DI DOPAMINA NELLA VIA MESOSTRIATALE, UNA VIA IMPORTANTE PER GLI EFFETTI COMPORTAMENTALI DELLA NICOTINA.
… (P)]. We synthesised a group of PIA-related peptides in which R1 was mutated or the RDP motif was gradually removed. Binding and functional studies showed that the RDP sequence is essential for the activity of PIA on the native rat α6β2* subtype, with a major role played by residue R1. …
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Discovery and design of novel bioactive peptides from amphibian skin secretion
… to obtain the sequences of natural antimicrobial peptides and their synthesis was achieved using solid-phase synthesis (SPPS). In addition, the peptides were purified and identified by high-performance liquid chromatography (HPLC) and MALDI-TOF MS, and their biological activity was …
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Simulações computacionais do peptídeo híbrido Plantaricina-Pediocina em membranas fosfolipídicas puras e binárias compostas por POPC: POPG
Peptídeos antimicrobianos são componentes importantes do sistema de defesa de diversos organismos contra possíveis invasores. Em geral, são pequenos (até 100 aminoácidos), catiônicos e anfipáticos. Eles têm despertado o interesse da comunidade científica por sua capacidade de atuação contra …