Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"hybrid compounds"”.
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Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores
… biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.
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Curcumin-related hybrid compounds as potential antimalarial agents : design, synthesis, mechanistic investigations, biological evaluation and pharmacokinetic studies
… a key priority. This study applied molecular hybridization as a strategy in the development of novel potential antimalarial agents. The aim was to try and identify novel hybrid compounds containing scaffolds that are structurally related to the natural product curcumin, and which exhibit in …
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An investigation into the molecular mechanisms induced by derivatives of natural products in oesophageal cancer
… together with novel artemisinin hybrid compounds, as cancer chemotherapeutic agents and explored the mechanism of action in oesophageal cancer. Artesunate and dihydroartemisinin including seventeen other artemisinin derivatives were screened against oesophageal cancer cells using …
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Synthetic and mechanistic study of catalytic dintrogen reduction
… a series of new triamidoamine based molybdenum compounds has been studied. The synthesis of a number of different triamidoamine ligands, and their resulting molybdenum compounds, is described. While symmetric variants containing electron-withdrawing hexaisopropyl terphenyl substituents can …
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Characterization of Plasmodium falciparum PFF1010c and screening of pyrimidine-quinoline hybrids as inhibitors of HsP70-HsP40 functional partnerships of the Malaria parasite
… The current study explored pyrimidine-quinoline hybrid (PQH1-4) compounds as possible inhibitors of PfHsp70-1 interaction with PfHsp40. Furthermore, this study sought to characterize the structure and function of PFF1010c. Notably, PFF1010c possess SVN residues in place of the HPD motif located …
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Development of aminoquinoline-benzimidazole hybrids and their organometallic complexes as antimicrobial agents against Plasmodium falciparum and Mycobacterium tuberculosis
… in tackling rising resistance is the use of hybrid chemotherapy, which involves the combination of two or more pharmacophores into a single compound. This study investigated the synthesis, characterisation and pharmacological properties of new organic and ferrocenyl …
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Synthesis and Characterisation of Dual CCR7/CXCR4 Antagonists
… antagonists have been synthesised, these are hybrid compounds incorporating features from CCR7 antagonists of this project, and from known sulfonamide CXCR4 antagonists. The most potent of such compound was able to inhibit CCR7 activation in calcium flux assay (95% inhibition at 1 µM), …
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Investigation of structural properties in biomolecular systems using synchrotron-based spectroscopies
… and submolecular scale in metalprotein hybrid compounds with the aim to identify the binding site of metal atoms or ions within protein molecules and the underlying interaction mechanisms. The most fundamental structural scale, the level of single bonds and molecular orbitals, is …
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Synthesis and Characterisation of Dual CCR7/CXCR4 Antagonists
… antagonists have been synthesised, these are hybrid compounds incorporating features from CCR7 antagonists of this project, and from known sulfonamide CXCR4 antagonists. The most potent of such compound was able to inhibit CCR7 activation in calcium flux assay (95% inhibition at 1 µM), …
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Molecular mechanism of Abeta recognition and neuroprotection by the glycoconjugate beta-sheet-breaker peptide Ac-LPFFD-Th
… proteins. We figured out that the development of hybrid compounds may provide new molecules with improved properties that might sinergically increase the potency of their single moieties. Since it has been demonstrated that Abeta oligomers are the toxic species, it becomes a priority to counteract …
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Development of novel lysine targeting covalent inhibitors for Bruton’s tyrosine kinase and casein kinase 2 and synthesis of novel hybrid androgen receptor inhibitors
… 1) The development of a novel class of hybrid compounds designed through covalently linking enzalutamide and EPI-001 through triazole-PEG linkers is reported. The compounds are accessed in 6 synthetic steps performed in parallel for the 5 final target compounds. The compounds display a …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
… design, synthesis, and biological evaluation of hybrid compounds as multitargeted anticancer agents. To this extent, an HO-1 inhibitory portion was coupled with different molecules endowed with antitumor activity. Since sigma receptors (sigmaRs) ligands showed potential antiproliferative effects …
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DEVELOPMENT OF NEW PEPTIDE-BASED NANOMATERIALS AS POTENTIAL TOOLS FOR CRYOPRESERVATION OF TISSUES AND ORGANS
… finding non-toxic and biocompatible antifreeze compounds that enable subzero storage and cryopreservation without causing tissue damage. As the synthesis of molecules to be used for cryopreservation represents an urgent need, in the last decades researchers have been extensively focused on it. …
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Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease.
… of this work was to design and synthesise novel hybrid compounds with the potential to be applied as multi-target therapeutics for AD. To achieve this aim, derivatives combining an antioxidant group with an aromatic system, which could act as a cholinesterase inhibitor or prevent the aggregation …
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Engineering site-isolated reactive metal complexes within a Metal-organic Framework
… of porous materials. They are organic-inorganic hybrid compounds consisting of organic ligands acting as linkers/spacers and metal ions or clusters as nodes/vertices. Combinations of these building blocks allow formation of three-dimensional periodic lattices with different pore shapes and sizes. …
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Triphenylene as a Scaffold for New Molecular Materials
… synthesis. There were a number of potential compounds to investigate from this versatile precursor. We chose to target BODIPY-triphenylene hybrid compounds. Two compounds were designed, one from the dialdehyde where the BODIPY fragment would be attached via the central meso-carbon, and one …
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Neue Untersuchungen zu Wachstum und Struktur von Fluorapatit-Gelatine-Nanokompositen
Die vorliegende Dissertation beschäftigt sich mit Wachstum und Aufbau von Fluorapatit-Gelatine-Nanokompositaggregaten. Diese Aggregate werden im sogenannten Doppeldiffusionsversuch biomimetisch erzeugt und ihre äußere Form bzw. Formentwicklung lässt sich anhand eines fraktalen Modells bis ins …