Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"hyaluronan"”.
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THE ROLE OF HYALURONAN IN INNATE INTESTINAL DEFENSE
Hyaluronan (HA) is a glycosaminoglycan polymer found in the extracellular matrix of all mammalian tissues and a component of human milk. Breast-feeding is associated with enhanced protection from gastrointestinal infection in infants. However, the function of naturally produced milk hyaluronan …
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The Role of Hyaluronan in the Ocular Surface
… maintaining ocular surface homeostasis. Hyaluronan (HA) is found in the extracellular matrices of the corneal limbus and meibomian gland (MG). This dissertation evaluated the role of hyaluronan in ocular tissues, particularly in the limbal stem cell niche and the meibomian gland. Methods: …
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Synthesis of Hyaluronan by Tumour Cells – Mechanism and Implications
Hyaluronan (HA) is a glycosaminoglycan found in the extracellular matrices of epithelial and connective tissues. It has both structural and signalling functions, triggering various cell signalling cascades, which result in adhesion, migration and invasion. It has been reported that Squamous Cell …
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Improving hydrophilicity of silicone elastomer by IPN formation with hyaluronan
… materials of poly(dimethyl siloxane) (PDMS) and hyaluronan (HA) with such properties. The results in this work indicate the successful synthesis of these HA-PDMS IPN materials. These elastomeric materials had improved hydrophilicity compared to untreated PDMS. Additionally, new chemical species …
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Příprava a charakterizace směsných hydrogelů na bázi systému hyaluronan-albumin
… charakterizací albuminových (BSA) a směsných hyaluronan-albuminových (HA+BSA) hydrogelů. Experimentální charakterizace byla založena na reologickém měření vlivu iontové síly, pH a molekulové hmotnosti hyaluronanu na proces gelace a vlastnosti vzniklých gelů, stejně tak jako na měření časové …
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Three-dimensional Hyaluronan-based Hydrogels Designed for Breast Cancer Spheroid Formation
… vivo tumour cell phenotype and microenvironment. Hyaluronan (HA) is upregulated in breast cancer stroma and thus an excellent starting material in which to culture breast cancer cells; however, HA itself is a viscous liquid. To create a 3D gel for the prolonged culture of breast cancer cells we …
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Synthesis and Characterization of Methacrylated Hyaluronan-Based Hydrogels for Tissue Engineering
<p>Polymers have revolutionized the field of tissue engineering due to the countless possibilities of scaffolds that can be constructed from such a material. Through conjugation of other functional groups onto a polymer backbone, the mechanical properties of polymers can be controlled and has the …
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Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation
… elevation of high molecular weight (HMW) tissue hyaluronan (HA) in skin is linked to tumor resistance in the naked mole rat. To directly assess the role of this polysaccharide in resistance to keratinocyte tumors, a HMW HA phosphatidylethanolamine (HA-PE) formulation that penetrates skin and …
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Regulation and function of hyaluronan binding by CD44 in the immune system
… for the extracellular matrix glycosaminoglycan hyaluronan, and is involved in processes ranging from metastasis to wound healing. In the immune system, leukocyte activation induces hyaluronan binding through changes in CD44 post-translational modification, but these changes have not been well …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… executing TGFβ ligand and High-Molecular Weight Hyaluronan (HMWHA) stimulated cell invasion. Hyaluronan (HMWHA) is a glycosaminoglycan unmodified sugar extracellular matrix (ECM) molecule synthesized by the Hyaluronan Synthase (Has) family of enzymes. Mouse embryos lacking Hyaluronan Synthase 2 …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
… pulmonary fibrosis (IPF). Additionally, hyaluronan, an extracellular matrix glycosaminoglycan has been associated with PH. The role and mechanism of NUDT21 and hyaluronan have not yet been described in this disease. My results reveal that NUDT21 depletion and APA in pulmonary artery …
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Role of Covalent Modification of Hyaluronan with Inter-Alpha Inhibitor Heavy Chains During Acute Lung Injury
… role in tissue maintenance, injury, and repair. Hyaluronan (also known as hyaluronic acid, HA) is a ubiquitous ECM polysaccharide consisting of a repeating disaccharide backbone that can be covalently modified by the heavy chains (HC) of the serum protein inter-alpha-inhibitor (IαI) during …
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Inflammatory astrocyte and T cell interactions are supported by hyaluronan in a murine model of Multiple Sclerosis
… astrocytes have increased expression of hyaluronan synthases. Hyaluronan is an extracellular matrix component that is primarily released by astrocytes in the CNS. It has been shown to accumulate in MS and EAE lesions and is thought to support encephalitogenic properties of T cells. …
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The Mechanism of Action of Hyaluronan Therapy as a Treatment for Osteoarthritis and the Assessment of Osteoarthritic Articular Cartilage Using Ultrasound
… two key aspects of OA management: (1) how hyaluronan (HA) therapy interacts with articular cartilage at the molecular and tissue level, and (2) whether quantitative ultrasound imaging can detect early degenerative changes in articular cartilage before irreversible osteoarthritic damage …
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IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
… survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the mechanism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung cancer cells. A synthetic IGFBP-3 peptide (<sup>215</sup>-KKGFYKKKQCRPSKGRKR-<sup>232</sup>) …
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Experimental study and computational modelling of the biomechanical properties of arteries
… In addition, a project investigating the role of hyaluronan in systemic inflammation-induced aortic stiffening has been carried out. Systemic inflammation occurs in several diseases such as rheumatoid arthritis which increases aortic stiffness and causes altered distribution and function of …
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Stressed Astrocytes: Insights on the Pathology of Alexander Disease
… several related proteins, including its ligand hyaluronan. I found CD44 protein expression greatly increased in the white matter, cortex and hippocampus of AxD patients and in the hippocampus of AxD mice. Additionally, through use of a biotinylated hyaluronan binding protein, I found abnormally …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… smooth muscle cell (SMC) interactions with hyaluronan (HA) mediated by the receptor for hyaluronan-mediated motility (RHAMM), affects arterial SMC adhesion, migration and collagen matrix remodeling in vitro as well as constrictive remodeling following artery injury in vivo.
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Design and Synthesis of Hyaluronan:RHAMM Interaction Inhibitors
A major component of the extracellular matrix is hyaluronan, a regulator of cell migration/survival and differentiation during response-to-injury processes. The receptor for hyaluronan-mediated motility (RHAMM) binds to HA and has limited constitutive expression but is upregulated during tissue …
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