Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"humoral response"”.
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An investigation into the Humoral Response in Cutaneous Melanoma
… (Rabbie et al., 2019). The T cell immune response in melanoma has been well defined, however, the B cell response is much less understood (Rodgers et al., 2022). Lymphoblastoid cell lines (LCLs) are immortal B cells which have been transformed via Epstein Barr virus (EBV) infection …
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Inhibition of the Humoral Response by Spleen Cells From Cyclophosphamide Treated Mice
Made available in DSpace on 2014-12-14T13:28:20Z (GMT). No. of bitstreams: 1 7915392.pdf: 3945145 bytes, checksum: 94f77eec7d8f8ff834670fcc7127067c (MD5) Previous issue date: 1979
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THE ROLE OF PSYCHOLOGICAL STRESS IN ALTERING THE HUMORAL RESPONSE TO CARDIAC CATHETERIZATION.
THE ROLE OF PSYCHOLOGICAL STRESS IN ALTERING THE HUMORAL RESPONSE TO CARDIAC CATHETERIZATION.
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Development of microanalysis tools for characterization of the humoral response to infections diseases
Antibodies are higher order protein structures produced by a subset of lymphocytes (B cells) in the immune system for protection against pathogenic species. These homodimers of heterodimers form highly specific interactions with their cognate antigens and hence have become very important for the …
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
… was to comprehensively characterize IgG response to EBV infection in humans. Currently, EBV serology is used to confirm the EBV infection status of a patient, but there are no clinical markers available to date to diagnose EBV-associated cancers. Out of the 80 proteins that the virus …
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Development of a Linognathus Vituli Infestation Model; Population Dynamics and Host Physiologic Changes in Both Normal and Stressed Cattle
Strong dermal response to infestation was measured through cellular infiltration of the skin by eosinophils, mast cells and lymphocytes. Infested and re-infested calves exhibited a marked IDST response. No systemic cell mediated response was detected. Infested animals mounted a humoral response to …
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Regulation of Protective B cell Anti-Tumor Responses
… in and contribute to the anti-tumor immune response. The totality of work presented in this document demonstrates novel roles for B-1 cells in the anti-tumor response. B-1a cells are important for the innate response against peritoneal carcinomatosis through the production of natural …
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Pigeon breeder's disease: the clinical spectrum and humoral response; an investigation of the nature and extent of extrinsic allergic alveolitis due to pigeon-derived antigens among pigeon fanciers continuing to pursue the pastime, with particular reference to early clinical and humoral-mediated responses following exposure
… among active pigeon fanciers, and the associated humoral responses to pigeon -derived antigens. Clinical data was obtained in questionnaire format from a large scale field study interviewing 100 pigeon fanciers. A wide range of skin tests were performed and serum antibodies were estimated by …
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A Flagellin-Poxvirus Antigen Vaccine: Strengths and Limitations
… a potent adjuvant that enhances adaptive immune responses to a variety of antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore, we evaluated the response to these …
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Probing the sensitivity of autoantibody production to B cell depletion by Rituximab
… increased plasma cell numbers. In the prolific humoral response of QM mice to immunisation with NP-Ficoll, concurrent infection with attenuated Salmonella enterica serovar Typhimurium increases splenic capacity to support plasma cells. The enhanced support may reflect locally increased IL-6 …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… their effects on anti-tumour B and plasma cell responses, which are now regarded as important components of the adaptive immune response to cancer. Additionally, the utility of ICB therapies is limited by the immune-related adverse events (IrAEs) they induce – toxic autoimmune conditions that …
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The Humoral Immune Response of Elks (Cervus elaphus nelsoni) and Mice to Vaccination with Brucella abortus Strain RB51
… an O-chain and thus a lack of an anti-O-chain humoral response greatly simplifies identification of vaccinated versus field strain infected animals. The three primary objectives of this research were the following: 1) to develop a serological assay to detect anti-RB51 antibodies in vaccinated …
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Investigating The Possible Role Of Regulatory T Cells In Suppressing DTwP And Measles-Vaccine Induced Responses In 9 Month-Old Gambian Infants
… and skewed towards Th2 and immunoregulatory responses. This results in high susceptibility to infections and impaired responses to vaccines. Regulatory T cells (Tregs) control pro-inflammatory responses and are therefore important in maintaining a fine balance of immune responses during …
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A B-cell or a key player?: The role of the humoral immune response in melanoma, highlighting the importance of method development
Investigations of the humoral immune response to melanoma have revealed that B-cells and antibodies can play both pro and anti-tumourigenic functions. B-cells can infiltrate melanomas and become organised into a tertiary lymphoid structure; their presence have been associated with better …
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The effects of topical calcipotriol treatment on immune responses to vaccination
… the elicitation of a contact hypersensitivity response. We also demonstrate that topical calcipotriol has significant effects on the immune response to subcutaneously injected vaccines, and compare it with another common topical immunosuppressant, the corticosteroid betamethasone-17-valerate …
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Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection
… is complex and requires both cell mediated and humoral immunity at different stages of infection. In infants in sub-Saharan Africa infection with non-typhoidal Salmonella (NTS), such as STm, can commonly cause fatal invasive disease. Evidence indicates that disease may be preventable by …
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Helicobacter pylori VacA as a mitochondrial targeted pathogenic effector
… In order to evaluate the host cellular response to VacA mediated mitochondrial dysfunction, cells were treated with VacA, where a robust induction of mitochondria dysfunction was observed, then upon removal of VacA, mitochondria dysfunction was observed to recover over time, indicating …
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Immunological responses of fishes to glochidia of freshwater mussels
… host and non-host species expressed a specific humoral response to glochidial antigens after being artificially infested with the parasites. Further microagglutination tests were completed to compare titers of host and non-host fishes which were either uninfested, infested, or reinfested with …
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Humoral immunity in colorectal cancer : evaluation of the anti-p53 and anti-hTERT auto-antibody responses
… Some of these changes are recognised by the humoral system and are known as Tumour Associated Antigens (TAA) against which the humoral system is able to mount an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the "2-hit" hypothesis …
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Development and Characterization of recombinant immunotoxins for cervical carcinoma
… causing cell death. ETA is prone to causing a humoral response within patients. This unwanted effect can be prevented by introducing point mutations into the ETA gene. The point mutations are to reduce the chances of an immune response from occurring whilst maintaining the cytotoxic activity of …
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