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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 333 for “"humoral"”.
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
<p>Humoral autoimmunity is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus …
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Humoral alloimmunity in cardiac allograft rejection
… on the impact of the different phases of the humoral alloimmune response (follicular or germinal centre) on graft rejection.
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… we can improve medical interventions to enhance humoral protection against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way their B cell receptors bind antigen and generate antibodies that provide protection …
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Innate and humoral immune responses to HIV-1
Understanding cellular and humoral immune responses to HIV-1 infection and designed HIV immunogens are imperative to the development of an effective anti-HIV vaccine. In this thesis we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to …
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Genetics, humoral immunoresponsiveness, and disease resistance in chickens
… the mode of inheritance of such competence. Humoral immunocompetence was evaluated by primary, memory, and maternal antibody responses to SRBC. Primary antibody response, measured 5, 10, and 20 days after inoculation with SRBC was greater in HA than LA chicks inoculated at 14, 21, and 28 days …
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An investigation into the Humoral Response in Cutaneous Melanoma
Melanoma is a cancer which develops from the malignant proliferation of melanocyte cells. There are 4 subtypes, of which cutaneous melanoma (CM), is the most prevalent (Rabbie et al., 2019). The T cell immune response in melanoma has been well defined, however, the B cell response is much less …
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Bruton's tyrosine kinase regulator of innate and humoral immunity
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Genetics and Evolution of Drosophila Humoral Immunity against Parasitoid Infections
… However, the regulation of Drosophila humoral immunity against parasitoids is not clearly illustrated. In this thesis, I investigated the humoral immune mechanisms underlying Drosophila resistance to parasitoid infections, as well as the evolution of humoral immunity in populations that …
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Humoral and cell-mediated immunity in vitamin A-deficient lambs
… HGG challenge period as compared to A-def lambs. Humoral immune function appears to be impaired in A-def lambs and a 2-wk repletion period was not sufficient in this study to restore humoral immune function to normal levels.
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The role of DEAD-box helicase 1 in humoral immune responses
A key characteristic of humoral immune responses is the ability of B-cells to recognise an endless array of antigens through their immunoglobulin (Ig) genes and secret these as soluble antibodies to help combat invading pathogens. Primary diversification occurs through VDJ recombination during …
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On the humoral mediation of the intestinal phase of gastric secretion
… of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by …
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Respuesta inmune celular y humoral del porcino ibérico frente a la metastrongylosis
… la valoración de la respuesta inmune celular y humoral que desarrollaron los porcinos frente al parásito, con objeto de evaluar el grado de resistencia frente a los diferentes tratamientos seguidos en el experimento. Para tal fin, se utilizaron 48 cerdos de raza Ibérica divididos en cinco …
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Characterizing Peripheral Cellular and Humoral Immune Responses to Haemonchus contortus in Sheep
Gastrointestinal nematode parasitism is the most widely reported health concern among sheep producers worldwide. The most concerning of which is Haemonchus contortus; a blood-sucking nematode found in the abomasum of sheep. Worldwide anthelminthic resistance has prompted exploration of alternative …
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Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
… These findings point to differentially polarized humoral immune responses in cutaneous tumor microenvironments. <br/>Lastly, an antibody derived from a patient was then selected and preliminary evaluations of reactivity and specificity to a range of melanoma cell lines and primary human …
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Inhibition of the Humoral Response by Spleen Cells From Cyclophosphamide Treated Mice
Made available in DSpace on 2014-12-14T13:28:20Z (GMT). No. of bitstreams: 1 7915392.pdf: 3945145 bytes, checksum: 94f77eec7d8f8ff834670fcc7127067c (MD5) Previous issue date: 1979
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Modulation of humoral immunity in the rat by 17beta-estradiol and prolactin
Females of many mammalian species possess a more vigorous immune response to a variety of antigens than do the males. Many studies have shown that prolactin (PRL) and estradiol (E$\sb2$) augment immunity. Given that E$\sb2$ is a potent physiologic stimulus for the release of PRL from the pituitary, …
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Methods, Models, and Machine Learning Approaches for Understanding Pathogen-Specific Humoral Immunity
The humoral immune response is comprised of vast libraries of polyclonal antibodies capable of recognizing a myriad of targets and directing a spectrum of innate immune functions. The complex heterogeneity in antibody profiles across both populations and diseases makes defining mechanisms of …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… of the role of these molecules during the humoral immune response, the oxidation events that modulate B cell signaling, and their contribution to B cell activation is limited. Therefore, we have examined the importance of the reversible formation of cysteine sulfenic acid on B cell …
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THE ROLE OF PSYCHOLOGICAL STRESS IN ALTERING THE HUMORAL RESPONSE TO CARDIAC CATHETERIZATION.
THE ROLE OF PSYCHOLOGICAL STRESS IN ALTERING THE HUMORAL RESPONSE TO CARDIAC CATHETERIZATION.
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An analysis of the cellular and humoral immune responses of Galleria mellonella larvae
… is composed of the intertwined cellular and humoral components which have similar structural and functional attributes to the mammalian innate immune system. For this reason insects have served as useful screening tools in academic and industry research for the assessment of pathogenicity of …
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