Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 105 for “"humanized"”.
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Radioimmunotherapy using 186Relabeled humanized monoclonal antibodies.
Contains fulltext : 58759.pdf (Publisher’s version ) (Open Access)
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Mucosal HIV-1 Transmission in Humanized Mice
… HIV-1 transmission, the susceptibility of humanized mice to intrarectal and intravaginal HIV-1 infection was investigated. Human lymphocytes, including CD4+ T cells, generated in situ from hematopoietic stem cells reconstitute the gastrointestinal tract and the female reproductive tract of …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… sclerosis. We here demonstrate the ability of humanized chimeric receptors to suppress experimental autoimmune encephalomyelitis (EAE) in a humanized mouse model by redirecting T lymphocytes against autoreactive T-cells. The receptors were synthesized by linking the 84-102 epitope of human …
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Modeling hematologic malignancies and their treatment in humanized mice
… and evaluating potential new therapies. Humanized mice - immunodeficient animals engrafted with human hematopoietic stem cells (HSCs) that subsequently give rise to various mature blood lineage cells - are an elegant solution to these problems, as they offer an ethical and practical way …
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Humanized mice to test vaccination against influenza virus via dendritic cells.
… value of these mice for testing human vaccines, humanized mice were immunized with1) ex vivo-generated DCs, 2) seasonal influenza vaccines and 3) protein antigens fused to anti-DC receptor. Upon vaccination with ex vivo-generated DCs pulsed with heat-inactivated influenza virus, mice developed …
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Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice
… response. In this regard, new advances with humanized mice(hu-mice), constructed by engrafting human tissues and cells and harboring a functioning human immune system, have been of great value in advancing research with human viruses Here we sought to utilize hu-mice to understand natural …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
… and diversifies at the expected rate within humanized mice (hu-mice) and that hu-mice can sustain HIV-1 viremia for up to 4 months, thus allowing hu-mice to be used as a small animal model to study HIV-1 therapeutics. Using hu-mice, I show that when administered as single agents, recently …
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Political Cosmopolitanism: A Humanized and Socialized Account of Global Citizenship in Action
In this thesis, I propose a humanized and socialized account of cosmopolitan global citizenship. Cosmopolitanism has merits and applicability in our globalized society, but its basis on universalism and impartiality can unjustly homogenize public discourse and limit citizenship activity. In my …
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Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
… The goal of these studies is to develop the humanized BLT mouse as a small animal model to study HIV/M.tb co-infection and identify mechanisms of HIV-mediated immune dysfunction that alter the protective response against M.tb infection. Humanized BLT mice are infected with M.tb and develop …
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Lethal Hypermutation Induced by the Innate Cellular Restriction Factor APOBEC Destroys HIV-1 in Infected Humanized Mice
… able to evade APOBEC restriction in vivo exists. Humanized mice used as an in vivo model to study the capacity of APOBEC to restrict Vif-defective HIV revealed that the ability of the virus to replicate is severely crippled. HIV lacking Vif is heavily hypermutated by APOBEC, however, if the virus …
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Humanized Mouse with a Diverse Polyclonal B Cell Repertoire as a Model for Neutralizing Antibody Responses against EBV and HIV
… project, I investigated the utility of these humanized mice as a surrogate to model VRC01-class B cell responses, a rare class of HIV broadly neutralizing antibodies that target the CD4 binding site on HIV envelope. I utilized high-throughput sequencing to identify the presence of these rare …
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Using machine learning to increase the predictive value of humanized mouse models for the human immune response to YFV-17D
… functional human immune system components, or “humanized”, to better model the human immune response. Continued translational failure led to the development of a second-generation humanized mouse model with enhanced myeloid and natural killer (NK) cell compartments, producing a stronger immune …
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… intestinal organoids derived from germ free and humanized mice. Typically, transport across the epithelial cell layers occurs by active transport and passive diffusion. Using mouse models that differ in bacterial content and fluorescence scanning, and live imaging techniques we studied the impact …
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Characterizing CMT-causing variants in tryptophanyl- tRNA synthetase
… identified in these enzymes. I created a humanized yeast model to assess the underlying disease-causing mechanism associated with two CMT variants, H257R and D314G, present in the human tryptophanyl-tRNA synthetase (WARS1). Using proteomic analysis, protein biochemistry, and yeast growth …
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Putative Roles of Cd200 In The Leukemogenesis and Immune Evasion of Leukemia Stem Cells
… a physiological setting, we established a PBMC-humanized mouse model, in which we could characterize progression of CD200+ and CD200- AML in the presence of an activate human immune response. Further, we used this model to compare the effects of CD200+ AML on the transcriptional activity and …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… islet transplantation.</p> <p>We also introduce humanized mouse model into the studies of islet transplantation. Humanized mouse model contains mature human immunity and is a good model to determine the immune rejection to human islet after transplantation. Our study is innovative because this is …
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Mitochondrial Dysfunction: A Mechanistic Link in the Progression from Normal Aging to Sporadic Alzheimer’s Disease
… by utilizing a mouse model expressing non-mutant humanized Aβ [humanized Aβ knockin (hAβ KI) mice, also referred to as a model of late-onset AD in previous literature], we identified concurrent synaptic mitochondrial deficiencies and intra-mitochondrial Aβ42 accumulation with age. Furthermore, …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… tissue location and antigen content; and 2. Humanized mouse models recapitulating human TME. Indeed, while syngeneic and genetically modified mouse models enable in vivo studies of the TME, substantial differences exist between human and mouse immune systems, possibly impacting translation of …
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