Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"humanised mice"”.
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Using humanised mice to understand Plasmodium falciparum growth and development
… interactions that can be explored in-vitro. Humanised mice (HuMice) are immunodeficient mice that can be engrafted with human cells and tissues. They are the only small animal model that can be used to study human restricted P. falciparum in-situ and may provide a unique opportunity to model …
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The development of a humanised mouse model of ANCA associated vasculitis
… the development of a disease model based on humanised mice, defined as mice possessing human immune cells, has the potential to overcome these limitations, while also allowing the direct study of human ANCA in vivo. The aims of this thesis were 1) to establish in vitro assays of ANCA induced …
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Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib
… and genetic background. The development of humanised mice, in which the gene or genes of interest have been excised from the genome and replaced with the functional human counterpart, may have the potential to bridge the gap between preclinical mouse models and human disease. The work …
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Estimating antimalarial drug activity in vivo: an interdisciplinary approach combing novel experimental data with mathematical modelling
… I consider novel parasite viability data from humanised mice and humans treated with two antimalarial drugs to develop a model of antimalarial drug activity and build a more nuanced understanding of parasite killing and host removal of dead parasites. The new assay we use for estimating …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… healthy kidney organoids were engrafted into humanised mice to enable in vitro immune co-culture assays to be extended in vivo. Twenty seven niche-derived secreted factors were detected in ccRCC. Among these, a novel combination of PDGFb and OSM especially supported PDO-ccRCC proliferation, …
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Development of a humanised mouse model of ovalbumin induced allergy and inflammation as a platform to test functional food
… have repeated efficacy of hydrolysates in a humanised mouse model setting In this study a large number of hydrolysates were screened in vitro to identify hydrolysates with anti-inflammatory properties In vitro we demonstrated that 147 hydrolysate significantly reduced DC maturation in a …
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The Immunogenicity of Cholangiocyte Cellular Therapies
… of COs in a transplant environment I used two humanised mouse models. I demonstrated that these models can induce an immune response against allogeneic COs and compared the response to allogeneic and autologous COs in both models. I identified HLA-matched CO lines and immune cell donors and …
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Modelling pancreatic cancer in vivo with patient derived organoids & humanised mouse models for the investigation of immunotherapeutic treatment response
… splenic mononuclear cell (SPMC)-derived HIS mice. I first assessed the immunophenotypic profile of lymphocytes, primary tumour tissue and adjacent tissue from patients with PDAC, intraductal tubular papillary neoplasm (ITPN) and ampullary carcinoma (AMP). I then outlined the derivation of …
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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites
… the PK studies in healthy and malaria-infected mice, analyte detection from whole blood was achieved using high-performance liquid chromatography coupled to tandem mass spectrometry. The bioanalytical methods were developed and partially validated based on a fit-for-purpose approach, which …