Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 110 for “"human tissues"”.
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Mutational processes in normal human tissues
… historical presence of mutational processes in tissues that may be linked to causes of diseases. During my PhD, I first characterised the operating mutational processes in normal human small intestine through extensive sequencing and phylogenetic reconstruction of multiple biopsies from a group …
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Impedance spectroscopy: non-invasive measurements for human tissues characterization
L'abstract è presente nell'allegato / the abstract is in the attachment
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Assessment of chromatin activity in mouse and human tissues
… from the active X chromosome in mouse and human tissues. In addition to this, in ~ nick translation has been used to distinguish constitutive heterochromatin in mouse and human mitotic chromosomes. Based on relative levels of DNAse I sensitivity, the inactive X chromosome could not be …
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Optical characterization of human tissues using low coherence interferometry
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Single-cell atlasing of the human tissues across the lifespan
… have revolutionised our understanding of human tissue biology in recent years. The Human Cell Atlas (HCA) initiative aims to recover and position all of the cell types in the human body. Being part of HCA, I have worked on building atlases which allow comparison across age groups for two …
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Expression of Usherin in Human Tissues: Implications for Diagnostics and Pathology
… localized in the basement membrane of several tissues, however it is not ubiquitous. Understanding localization of usherin is a key first step in defining its function in vivo. These studies aimed to define the pattern of usherin expression in human tissues. Immunohistochemistry detected …
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Quantitative Analyses of Normal and Precancerous Somatic Evolution in Human Tissues
… measurable quantities in normal and precancerous tissues. Genetic alterations under positive selection in ostensibly healthy tissues have implica tions for cancer risk. However, total levels of positive selection across the genome remain unknown. How much positive selection elsewhere in the genome …
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Assessing the usage of alternative transcripts in human tissues from RNA-seq and proteomics data
… Moreover, by applying this analysis to different tissues, it can be assessed if there are changes in splicing between different conditions and if such a change has a biological role. A dataset of 32 normal human tissues was used in this study. The results show that, although alternative splicing …
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Biochemistry in healthy and neoplastic human tissues: metabolic alteration revealed by HR-MAS nuclear magnetic resonance spectroscopy
… thesis is focused on the metabolomic study of human cancer tissues by ex vivo High Resolution-Magic Angle Spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy. This new technique allows for the acquisition of spectra directly on intact tissues (biopsy or surgery), and it has become …
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Comparison of polychlorinated biphenyl profiles in rat, fish and human tissues; the effects of consuming Great Lakes fish
… Biphenyl (PCB) congeners was assessed in rat and human tissue after the consumption of contaminated Great Lakes fish. Fish from Lake Superior (LS), Lake Michigan (LM), and Lake Huron (LH) were examined for either total PCB or specific congener concentrations. Total PCBs were highest in carp, lake …
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The Structural Requirements of Gastrin and Glycine-Extended Gastrin for Binding to Receptors from Normal and Cancerous Human Tissues
… requirements for binding of gastrin to the human CCK2 receptor and the existence of receptors for gastrin peptides on human colon cancer cells were investigated. CCK2 receptor studies focused on the importance of the C-terminal Phe and putative P- tum region of gastrin 17 (G17). Gastrin …
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The effects of angiotensin converting enzyme inhibitors (ACEI) on human N-acetylseryl-aspartyl-lysyl-proline (AcSDKP) levels : a systematic review
… have similar effects on AcSDKP and fibrosis in human tissues. Objective: To systematically review the effects of ACEIs on Ac-SDKP levels in human tissues. Methods: We searched five electronic databases (1996-2014) and conference abstracts with no language restrictions. Two reviewers …
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Low-power dual-band on-body antenna for wireless body sensor networks
… medium is not the free space as the human tissues constitute part of the transmission channel. The effects of the human body should be taken into consideration during the antennadesign.The present thesis aims to arrive at the optimum design of the on-body antenna to operate as a …
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Somatic Mutation in Cancer and Healthy Human Tissue
Somatic mutation is a natural process in healthy human tissues but has significant implications in a range of disorders and diseases with cancer being the most prominent example. In the last decade, genomics research generated big data resources that contributed tremendously to our understanding …
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Characterisation of the Apelin Receptor and its Endogenous Ligands, Apelin and Elabela/Toddler in the Cardio-Renal System
… to apelin and apelin receptor in mouse and human tissues; to identify specific isoforms of ELA produced in human tissues and metabolites of ELA-32 in plasma and kidney homogenate, as well as determining [Pyr1]apelin-13 metabolites generated in vivo in humans. ELA mRNA was expressed in mouse …
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Functional analysis of 5-hydroxymethylcytosine
… of single-copy gene expression. In the human genome the majority of CpGs are methylated whereas regions with high density of CpG sites, termed CpG islands and often co-localized within gene promoters, are typically free of this mark. Recently, a new modified cytosine, …
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Engineering polymer biomaterial interfaces for promoting cellular morphogenesis
… organ cultures have immense promise as models of human pathophysiology and stand to make a significant impact on the process of drug discovery and development. Many existing model systems do not capture the relevant complexity of the native tissue environment, relying on poorly characterized …
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NK cell determinants of immunity to mycobacterium tuberculosis in humans
… TB disease and to characterize NK subsets across human tissues in TB and healthy controls. In this thesis, NK cells were studied in a cohort of Mtb-infected adolescents who were followed up over two years. Using mass cytometry, results showed that cytokine responses by NK cells in the peripheral …
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