Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"human telomeres"”.
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Influence of Kaempferol on Noncanonical DNA Structures and Protein Aggregation
… G<sub>4</sub> tetraplexes) are commonly found in human telomeres and protooncogenes, which can serve as potential targets to treat cancer. Therefore, since KMP has been implicated in crossing the nuclear membrane as well as the blood brain barrier it is of interest to investigate for future …
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Structural dynamics of telomeric overhang accessibility
Telomeres are dynamic nucleoprotein complexes that cap and protect chromosome ends from deleterious degradation and fusion events. In most eukaryotes, telomere length is regulated by a basal level of telomerase, a specialized reverse transcriptase, which can add telomeric repeats to the 3’ end of …
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Identification and Characterization of the DNA Damage Response Function of Human Rif1 and a Search For Human Rap1 Interacting Factors
… did not reveal an association of human Rifl with telomeres. Preliminary co-immunoprecipitation with known telomeric proteins and chromatin immunoprecipitation failed to show an interaction of human Rifl with telomeric protein complexes or with telomeric DNA. Unexpectedly, Rifl …
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Investigating Mechanisms of Telomere End-Protection
… factor and was later shown to bind directly to telomeres. Two important functions of Rap1 in yeast are: the negative regulation of telomere length, and the inhibition of the double-strand break (DSB) repair pathway non homologous end-joining (NHEJ). Mammalian Rap1 interacts with shelterin factor …