Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"human tauopathies"”.
-
Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias
… to elucidate the molecular mechanisms underlying human tauopathies, with an emphasis on Alzheimer’s disease (AD)—the most prevalent and well-characterized tauopathy. Pathological tau species are among the earliest inclusions observed in post-mortem brains of individuals with dementia and strongly …
-
Analysis of axonal transport and molecular chaperones during neurodegeneration in drosophila
… neurodegeneration. Animal models that express human disease genes and show neurodegenerative-like pathologies are widely used to study particular molecular systems in early neurodegenerative changes. Axonal transport (AT) is perturbed in several prevalent neurodegenerative diseases. The …
-
Autophagy gridlock in tauopathy
Tauopathies are a group of neurodegenerative diseases characterized by the presence of intracellular aggregates containing the microtubule associated protein tau. Bulk degradation of aggregation-prone proteins can occur via autophagy. Here, we utilized the previously developed model of human …