Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"human skeletal muscle"”.
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Muscle-specific considerations for aging human skeletal muscle
… some evidence that the age-associated change in skeletal muscle mass is muscle specific, yet the number of specific muscles that have been studied to form our understanding in this area is limited. In addition, few aging investigations have examined multiple muscles in the same individuals. This …
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Magnetic resonance elastography studies of human skeletal muscle
… and analysis protocols optimised to study thigh muscle mechanical properties. The protocols are subsequently applied in healthy volunteers to study natural phenomena such as contraction and ageing and interventions such as an experimental protocol to produce Exercise Induced Muscle Damage (EIMD). …
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Exercise induced pain and damage in human skeletal muscle
Two types of dynamic muscle contractions have been compared to investigate their effects on muscle pain and damage in normal subjects. Damage was assessed by studying changes in isometric force generation, muscle enzyme loss, morphological changes and the patterns of radioisotope uptake. Delayed …
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Behaviour of single motor units in human skeletal muscle
… regulated by length and tension receptors in the muscle. Procainisation showed the importance of the gamma- regulated length receptors in voluntary contraction. In hypertonie Parkinsonism, however, increments of voluntary contraction are presumably largely dependent on recruitment of extra units. …
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Mechanisms Regulating Resistance Training Mediated Hypertrophy in Human Skeletal Muscle
… established that resistance training induces muscle hypertrophy, although the mechanisms and influence of biological sex are unclear. The extent of post-exercise myofibrillar protein synthesis (MyoPS), satellite cells (SC) and dietary amino acids to promote muscle hypertrophy have generally …
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Proteomic analysis of diurnal variation in human skeletal muscle performance
Phenotyping of human muscle based on its profile of myosin heavy chain isoforms is commonly used to help understand changes in muscle function. However, in many instances, measureable changes in force output or contractility occur in the absence of any change in myosin heavy chain profile. …
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Exercise and free radical induced damage to human skeletal muscle
… exercise and free radical induced damage to human skeletal muscle, with a review of related literature. It has been proposed muscle adapts to eccentric exercise by increasing its resting length. The first study investigated the effects of manipulating knee extensor (KE) length during …
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Role of MicroRNAs in Human Skeletal Muscle Tissue Engineering In Vitro
… development of a functional tissue-engineered human skeletal muscle model in vitro would provide an excellent platform on which to study the process of myogenesis, various musculoskeletal disease states, and drugs and therapies for muscle toxicity. We developed a protocol to culture human …
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The capillary supply of human skeletal muscle in health and disease
… exchange with cells. The capillary supply of skeletal muscle is highly organized, and therefore, represents an excellent choice to study factors regulating diffusion. Muscle is comprised of three specific fibre types, each with specific contractile and metabolic characteristics, which …
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The effect of sprint training on human skeletal muscle purine nucleotide metabolism
… was to examine the effect of sprint training on skeletal muscle purine nucleotide (PnN) metabolism. Specifically, this thesis studied the effects of sprint training on skeletal muscle PnN and metabolites of purine catabolism at rest, during a 30 s "all out" cycle bout and after 3 min of recovery. …
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Effects of altered physical activity on human skeletal muscle sarcoplasmic reticulum calcium regulation
… the rates of contraction and relaxation in skeletal muscle. However, little is known about SR function in human skeletal muscle. This thesis therefore investigated several factors that could potentially influence SR function in human skeletal muscle, including the effects of acute exercise, …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
<p>Tissue-engineered skeletal muscle presents promising opportunities for developing high-fidelity in vitro models for investigating human muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite cells (SCs) are essential for new muscle fiber formation; however, …
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Investigations into the mechanism behind COX-inhibiting drug regulation of human skeletal muscle mass
Access to abstract permanently restricted to Ball State community only.
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Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
… and controversial. To investigate this, primary human skeletal muscle myotubes from severely obese subjects (BMI [greater-than or equal to] 40 kg/m2) were isolated from muscle biopsies, and both resveratrol and contractile activity were examined. Specifically, 24 hours of resveratrol treatment (1 …
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Effect of aging and lifelong exercise on the innate immune system in human skeletal muscle
Access to abstract permanently restricted to Ball State community only.
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The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase
… glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area …
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Exploring metabolic and molecular mechanisms regulating age-related declines in human skeletal muscle regenerative capacity.
… underlying mechanisms regulating the ability of skeletal muscle to regenerate after acute “damaging” eccentric or “non-damaging” concentric exercise in young human skeletal muscle is poorly defined. Age-related impairments in the regenerative mechanisms may contribute to the age-related loss of …
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
… of impulses from the alpha-motor nerve to muscle fibers. Cerebral palsy is a neuromotor disorder that has been characterized by deficits in the central nervous system and, more recently, disruptions in the peripheral nervous system at the neuromuscular junction. The specific mechanisms …
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Effect of selected drugs on mitochondrial metabolism in an in vitro model of human skeletal muscle
… mitochondrial damage by in vitro exposure of human skeletal muscle-derived cells to a range of...
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