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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"human serum albumin"”.
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Human Serum Albumin Characterisation and Binding Studies by Spectroscopic Techniques
Human Serum Albumin (HSA) is a plasma protein of great significance with an ability to bind numerous endogenous and exogenous ligands, having a single polypeptide chain of 585 amino acids constructed in three domains of relatively equal size. Although HSA's existence has been known for many years, …
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Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production
… fermentation of recombinant Pichia pastoris for human serum albumin (HSA) production is a high oxygen demand process. The oxygen demand is usually met by increased agitation rate and use of oxygen-enriched air. Microbubble fermentation however can supply adequate oxygen to the microorganisms at …
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Design of Human Serum Albumin and Adenovirus Conjugation via Catcher/Tag Molecular Glue
… have demonstrated the remarkable capacity of human serum albumin (HSA) to extend plasma half-life and facilitate targeted intranasal delivery. In this study, we devised an innovative method for employing the Catcher/Tag molecular glue to shield Ad with HSA at a molecular precision level. The …
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Modification of the Bovine Genome for the Large-Scale Production of Human Serum Albumin
There is a vast clinical need for human serum albumin (HSA) with nearly 500 metric tons used worldwide every year. As a major protein in the human body, HSA plays a vital role in many physiological processes including the maintenance of oncotic pressure and the transport of various biomolecules and …
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Copper chelating anti-inflammatory agents of pseudo-mimics of human serum albumin (HSA) : copper and rheumatoid arthiritis
The objective of the study was to develop copper based anti-inflammatory agents for alleviation of inflammation associated with RA.
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EFFECTS OF OSMOLYTES ON THE CONFORMATIONAL STABILITY AND HYDRODYNAMIC RADII OF IMMUNITY PROTEIN 9 AND HUMAN SERUM ALBUMIN
… of the colicin E9 immunity protein (Im9) and Human serum albumin (HSA) were determined in the absence and presence of osmolytes (trehalose, sucrose, and glycerol) and their effective hydrodynamic radii measured in order to further explore the mechanism of stabilisation. Urea1/2, the midpoint …
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Potential Impacts of Pharmaceutical Uses of Transgenic Tobacco: The Case of Human Serum Albumin and Gaucher's Disease Treatment
… The first paper (chapter 2) examines the case of Human Serum Albumin production from transgenic tobacco. The second paper (chapter 3) examines the case of Glucocerebrosidase Enzyme from transgenic tobacco. Results demonstrate that new products from bio-pharming applications stand to generate …
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Investigating the molecular origins of biocompatibility : intermolecular interactions between human serum albumin and various chemically modified surfaces via high resolution force spectroscopy
… The model protein chosen for our study was human serum albumin (HSA), the smallest and most abundant blood protein in the human body, and typically the first to adsorb to a blood-contacting, implanted device. In the first stage of our investigation, HSA was covalently grafted to a nanosized …
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Rotational Dynamics and Proton Relaxation of MRI Paramagnetic Contrast Agents
… linked to dendrimers, non-covalently linked to human serum albumin, and taken up within rat hepatocytes. Dendrimeric contrast agents also tumble anisotropically. On the other hand, a two population model must be used to describe the rotational dynamics of contrast agents in a human serum albumin …
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Liquid Crystal Mediated Bioassay for Protein Detection
Detecting human serum albumin (HSA) in urine samples is a standard procedure for diagnosis of kidney problems and prognosis of patients with chronic kidney diseases (CKDs). This PhD work developed a HSA assay by incorporating a thin layer of liquid crystals (LCs) as a readout system such that the …
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QUANTITATIVE DETECTION OF LIVER-RELEVANT BIOMARKERS BY SERS-IMMUNOLABALED GOLD NANOPARTICLES
… intended for use in a microfluidic device. Human Serum Albumin (HSA) and α-Glutathione S-Transferase (α-GST) are liver biomarkers that indicate liver health and damage respectively. Herein we demonstrate
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Luminescent Quantum Dot and Protein Composite Nanoparticles for Bioanalytical Applications
… and application of magnetic, fluorescent human serum albumin nanoparticle composites. A fluorescent drug analogue and iron oxide nanoparticles were encapsulated into 100 nm human serum albumin nanoparticles. The advantage of these composite particles is that they could be used as a …
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Design, Development and Evaluation of Dual Drug Nanomedicine for Non-Small Cell Lung Cancer
… chemo sensitizer agent)- were developed on human serum albumin-tannic acid nano-platform (HTA) for targeted treatment of NSCLC.Our in vitro results demonstrate that Gem and GA combination therapy has tremendous potential due to their high efficacy on NSCLC, and GA sensitize NSCLC to Gem …
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Investigation of the crystallisation inhibitory properties of albumin isolated from the urine of Black and White South Africans
… the crystallisation inhibitory properties of albumin isolated from the urine of healthy black (BA) and healthy white (WA) South Africans as well as those of human serum albumin (HSA). Albumin was selected because previous studies on other population groups had revealed that the protein …
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Synthesis of Resveratrol Ester Derivatives
… and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted …
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Synthesis of doxorubicin-albumin conjugates via cobalt coordination chemistry: The effect of reaction conditions on overall protein stability
… observed in chemotherapy. In this context, human serum albumin could act as a nanoscale delivery vector to alter the biodistribution of attached therapeutics. This research explored the use of cobalt coordination chemistry in the synthesis of Doxalbumin conjugates. Doxorubicin was chosen …
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Identification and Quantification of Protein Carbonylation by Mass Spectrometry
… the modification of two model proteins, human serum albumin (HSA) and aconitase (ACO), by the LPO-relevant a, b-unsaturated aldehydes, acrolein (ACR) and 4-hydroxy-2-nonenal (HNE). The investigation is focused on the characterization and quantification ACR and HNE addition to the model …
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Adsorption of Blood Proteins onto Polysaccharide Surfaces
… of two platelet adhesion-related blood proteins, human serum albumin (HSA) and human serum fibrinogen (HSF), on two polysaccharide materials used for hemodialysis membrane applications: regenerated cellulose and cellulose acetate. The study aims to provide insight into the design of novel …
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EFFECT OF WATERCRESS EXTRACT AND KAEMPFEROL AGAINST OXIDATIVESTRESS
… hydroxyl radical-induced oxidative damage on human serum albumin (HSA) was investigated. Hydroxyl radicals, the most reactive free radicals, were generated via the Fenton reaction (1mM FeSO4 with 7mM H2O2) and their presence was confirmed by the methylene blue bleaching test. Spectroscopic …
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