Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"human rotavirus"”.
-
Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
Human rotavirus (HRV) is a major causative agent of acute gastroenteritis (AGE), which causes severe dehydrating diarrhea in children under the age of five and results in up to 215,000 deaths worldwide each year. There are two live oral attenuated vaccines licensed for use in the United States that …
-
Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
… Using gnotobiotic (Gn) pigs transplanted with human gut microbiota (HGM), we studied the effects of HGM on the immune response to oral rotavirus vaccination and rotaviral disease. We also used HGM transplanted Gn pigs to determine the effects of HGM on human norovirus infection. Despite …
-
Prevalance and epidemiology of rotavirus infection in infantile diarrhoea at the Diarrhoeal Training Unit of the University Teaching Hospital of Lusaka, Zambia
… University Teaching Hospital of Lusaka (Zambia), Rotavirus was isolated in 29 out of 152 infants (19.08%) with acute diarrhoea and in 1 out of 78 (1.28*) infants without diarrhoea.Rotavirus detection rate was related to humidity, but not to ambient temperature,and was independent of sex. The …
-
Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… and evaluating vaccine and therapeutics for human enteric pathogens. Here, we demonstrate Gn pigs as effective large animal models for human enteric viruses, through evaluating human enterovirus 71 (EV71) infection and immunity, and vaccine and therapeutics for human rotavirus (HRV). Gn pigs …
-
Mechanisms of Immunomodulation By Probiotics: Influence of Lactobacilli On Innate and T Cell Immune Responses Induced By Rotavirus Infection and Vaccines
… on innate and T cell immune responses induced by rotavirus infection and vaccines in a gnotobiotic pig model of human rotavirus (HRV) infection and vaccination. We first studied the effects of probiotics on antigen-presenting cells (APCs) through TLR activation. We found that a mixture of …
-
Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
Norovirus and rotavirus are the most common viral causes of acute gastroenteritis among all age groups and in children under 5 years of age, respectively. Understanding the pathogenesis of the virus and correlates of protective immunity is fundamental to developing effective prevention and …
-
Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
Clostridioides difficile (C. difficile) and human rotavirus (HRV) are leading causes of bacterial and viral gastroenteritis worldwide. Treatment and vaccination options for both pathogens have significant limitations. C. difficile infections are treated with antibiotics, which is paradoxical as C. …
-
The development of a pseudo-mechanistic model of solar irradiation-induced inactivation of viruses in wastewater and natural waters
… inactivation of viruses that are hazardous to human health. However, this sunlight disinfection is an unintentional byproduct of traditional WSP design, and consequently virus concentrations are not always reduced to sufficient levels. With the aim of improving virus inactivation in waters …
-
Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
Human rotavirus (HRV) and human norovirus (HuNoV) are the most common causative agents of acute gastroenteritis- (AGE) related morbidity and mortality around the world. Gnotobiotic (Gn) pigs are the ideal large-animal model that allows for accurate, and precise, preclinical evaluation of vaccine …