Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"human pluripotent stem cells (hPSC)"”.
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Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells
… recapitulate drug metabolism. However, they lack stem cell ability and therefore cannot multiply, and will vary depending on each donator. Toward this, hepatocytes derived from human pluripotent stem cells (hPSC-HEP) recapitulate many features of their in vivo counterparts. However, the …
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EZH1 variants disrupt neurogenesis in hPSC-derived neuronal models and cause neurodevelopmental disorders
… EZH2 is highly expressed in dividing cells, and its dysfunction leads to defects in neural progenitor proliferation and fate specification. In contrast, the contribution of EZH1 to transcriptional silencing and neurodevelopment or disease is poorly understood. By mining publicly …
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Role of the cell cycle during human endothelial-to-haematopoietic transition
Haematopoietic stem cells (HSC) are responsible for the maintenance of blood homeostasis and are of fundamental importance for the treatment of a variety of life-threatening diseases. However, their scarce availability constitutes a major obstacle. Thus, understanding their embryonic specification …
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BNC1 Regulates Human Epicardial Heterogeneity and Function
… transition (EMT), epicardial cells migrate into myocardium, form coronary smooth muscle cells and cardiac fibroblasts, and instruct cardiomyocytes to proliferate and mature. Adult mammalian epicardium is quiescent, but reactivates post-injury with limited effect. However, in …
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4D Control of Tissue Development and Blood Vasculature using Photo-mediated Chemistries
… and conserved organization between all its system components. Blood, blood vessels, extracellular matrix (ECM), and parenchyma interact dynamically, existing in a state of constant cross-talk and regulation. Yet for all we have discovered about physiologic and pathophysiologic organ function, …