Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"human papillomaviruses"”.
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Cutaneous Human Papillomaviruses
Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of …
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Human Papillomaviruses in oesophageal cancer
Bibliography: p. 207-213.
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Human papillomaviruses of skin and genital lesions
… 5% of all cancer cases worldwide are caused by human papillomavirus (HPV) which has been established as the cause of cervical cancer and genital warts (condylomas). Cutaneous HPV types have been weakly associated with non-melanoma skin lesions such as squamous cell carcinoma (SCC) and actinic …
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Human papillomaviruses in skin cancer and cervical cancer
… between persistent genital infections with human papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated whether …
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Novel Cutaneous Human Papillomaviruses and Biomarkers in the Skin Lesions
… the development of NMSC is UV-irradiation but human papillo-mavirus (HPV) might be a co-factor. We extended the heterogeneity of the genus Betapapillomavirus by characterizing six putative types, HPV93 (species 1), 96 (species 5), 107, 110, 111 and FA75[KI88-03] (species 2). The prevalence of …
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MOLECULAR PERSPECTIVES OF THE EPIDEMIOLOGY, EVOLUTION AND TAXONOMY OF HUMAN PAPILLOMAVIRUSES
… virus evolution, taxonomy, and identification of papillomaviruses are inextricably linked to the wider issues of papillomavirus epidemiology. In our studies, we have designed experiments and databases for the reliable assessment of HPV genomes from lesions, through the use of Polymerase Chain …
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Dental hygienists' role in education of oropharyngeal cancers caused by human papillomaviruses: a thesis
<p>"This qualitative design study collected Likert style survey data to describe feelings, perceptions, and attitudes of dental hygienists about their knowledge about oral HPV and its associated risks for OPC. The research quantitatively analyzed the dental hygienists responses from the survey to …
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E7 PROTEINS OF HIGH-RISK (TYPE 16) AND LOW-RISK (TYPE 6) HUMAN PAPILLOMAVIRUSES REGULATE p130 DIFFERENTLY
Human papillomaviruses (HPVs) are one of the most common causes of sexually transmitted disease in the world. HPVs are divided into high-risk (HR) or low-risk (LR) types based on their oncogenic potential. HPVs 16 and 18 are considered HR types and can cause cervical cancer. HPVs 6 and 11 are …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
Human papillomaviruses (HPV) typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the …
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Small Molecule Inhibitors of HPV16 E6
<p>High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the …
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Real time PCR and fluorescent in situ hybridization in the detection of the physical tsate of human papillomavirus 16 and 18 in paraffin embedded cervical tissue
Human papillomaviruses (HPV) are the etiologic agents of most cervical dysplasia and all cervical carcinoma. Integration of high risk HPV into the human genome is thought to be a critical event in the progression from cervical dysplasia to invasive cervical carcinoma. The ability to use molecular …
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Inhibition of the transcription factor AP-1 in cervical cancer
… AP-I is shown to play an important role in many human cancers and plays a key role in the regulation of the E6 and E7 oncoproteins of high-risk Human Papillomaviruses (HPV) that are etiologically associated with cervical cancer. The c-Jun and Jun B components of AP-I were shown to be expressed at …
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Pseudovirions in the Study of Papilloma- and Polyomaviruses
… polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present infections to elucidate …
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Longitudinal Keratinocyte Proliferation Induced by Human Papillomavirus 16E6 and NFX1-123 Partnership
High-risk human papillomaviruses (HPV) cause cervical, anogenital, and head and neck cancers. Despite the availability of preventive HPV vaccines, their poor uptake leaves most men and women at risk for these cancers, many of which remain common globally and others that are increasing domestically. …
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Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix
… worldwide. Persistent infection with high–risk human papillomaviruses (HPVs) is causally associated with cervical cancer. High–risk HPV E6 and E7 oncoproteins promote cell proliferation by inactivating p53 and pRb cellular tumor suppressors, respectively, which accelerates cervical …
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An investigation of post-translational modification of human papillomavirus E4 and the role of modified E4 proteins during the virus life cycle
Infection with human papillomaviruses (HPV) is the etiological basis for cervical cancer. The HPV E1^E4 protein is proposed to be a major regulator of the HPV life cycle and the multiple and diverse activities associated with E1^E4 suggest that it is a multi-functional protein. This thesis has …
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Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
Human papillomaviruses (HPVs) are DNA viruses that cause benign and malignant tumors of epithelial origins. Expression of HPV-encoded E6 and E7 oncoproteins is controlled by the viral E2 protein, which plays a dual role in gene activation and repression. Recently, we identified …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
Human papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the …
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Diversity of Skin Infections
… radiation is an established risk factor. Human papillomaviruses (HPVs) have been established as the major cause of cervical cancer. Many NMSCs contain one or several cutaneous types of HPV. Exploration of a possible infectious etiology of NMSC requires an unbiased and comprehensive …
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