Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"human organoids"”.
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The Role of Cervical Reserve Cells in Epithelial Regeneration and Homeostasis in the Murine and Human Cervix
… homeostasis and repair, and how the high-risk human papilloma viruses (HR-HPV) drive neoplasia at the cervical transformation zone (TZ) has been poorly researched. The cervical TZ is thought to be a stem cell niche as it harbours a unique cell population called reserve cells. Reserve cells …
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Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair
… managed to establish a system to grow primary human liver cancer cells long-term (Broutier et al., in press). Interestingly, the tumour-derived organoids (tumoroids) recapitulate the original tumour histology and genetic alterations and are also able to generate tumours in an in vivo xenograft …
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Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
The evolutionary lineage of humans is marked by a rapid expansion in brain size. Efforts to study human brain evolution have characteristically relied on anatomical and genomic comparisons between adult ape brains, meaning that the molecular mechanisms underlying human-specific brain expansion …
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Characterisation of human enteroendocrine cells in organoid models
… of this project, it was not possible to identify human EECs without prior fixation and immunostaining which precluded functional studies. We therefore used CRISPR-Cas9-mediated knock-in to generate human intestinal organoids with fluorescently labelled EECs. Organoids are three dimensional …