Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 52 for “"human neuroblastoma"”.
-
Notch Signaling in Human Neuroblastoma Cells
Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, …
-
Hypoxia-induced phenotypic modulation of human neuroblastoma cells
Neuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. In earlier studies we have found that hypoxia induces dedifferentiation of …
-
Effects of mitochondrial dysfunction on neurofilament turnover and distribution in human neuroblastoma cells
… turnover and the role of NFs in PD using the human SH-SY5Y neuroblastoma cell line, commonly used as a cellular model of neurodegeneration. Mitochondrial dysfunction, dopamine (DA) mediated oxidative stress and impaired protein degradation have all been implicated in PD pathogenesis. The …
-
A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… (MPTP) in an in vitro model SH-SYSY human neuroblastoma cells were explored using cytotoxic effects, neurochemical changes and pathological injury as endpoints. The results suggested that: MPTP entered the SH-SYS5Y human neuroblastoma cells through a non-dopamine transport mechanism, …
-
Purification and Characterization of the Plasminogen Activator From the Human Neuroblastoma Cell Line, Sk-N-Sh
The plasminogen activator produced by the human neuroblastoma cell line, SK-N-SH, has been purified and its enzymatic, immunological, and physical properties have been characterized and compared to the properties of human urokinase. The purification scheme involves concentration of the SK-N-SH
-
Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… disease and stroke. Cell therapy using human bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC using by transwell have effects against apoptosis induced SH-SY5Ys. …
-
The M(1) muscarinic receptor and its second messenger coupling in human neuroblastoma cells and transfected murine fibroblast cells
… and not to the adenylate cyclase system in human neuroblastoma SH-SY5Y cells. The maximal carbachol(CCh)-stimulated [³H]IP₁ accumulation in the SH-SY5Y cells was decreased in the presence of 1 μg/ml pertussis toxin, suggesting that a pertussis toxin sensitive G-protein may be involved in the …
-
Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
… and patterning of differentiation of SH-SY5Y human neuroblastoma cells exposed to IGF-I. and phorbol 12- myristate 13-acetate (PMA) To down-regulate REST expression we developed an antisense (AS) strategy based on the use of phosphorothioate oligonucleotides (ODNs). In order to evaluate REST …
-
Human Neuroblastoma, Strain Sk-N-Sh, as a Model System of Nerve Cell Differentiation: Neuronal Development, Plasminogen Activator Release, and Unscheduled Deoxyribonucleic Acid Synthesis
… and biochemical properties of the cultured human neuroblastoma, strain SK-N-SH, maintained in vitro. In complete growth medium supplemented with 15% fetal bovine serum, SK-N-SH cells exhibited a large nucleus, with several distinct nucleoli, and neurite- and dendrite-like processes with …
-
The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
One of the worst subtypes of neuroblastoma is caused by the amplification of a 130 kb genomic DNA region containing the MYCN oncogene. While MYCN has been extensively investigated, it is unknown whether other genomic elements within the 130 kb amplicon play a role in neuroblastoma. In this study, I …
-
AGGREGATION MECHANISMS OF TDP-43 PROTEIN IN RESPONSE TO STRESS IN AMYOTROPHIC LATERAL SCLEROSIS AND THERAPEUTIC APPROACHES
… ALS. Aim of this work was therefore to generate human 2D and 3D in vitro models of TDP-43 proteinopathy, recapitulating TDP-43 cytoplasmic mislocalization and loss of nuclear function, to be used for drug screening approaches. We induced a chronic and mild oxidative insult by sodium arsenite …
-
The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells
… various activities of the proteasome in SH-SY5Y human neuroblastoma cells treated with the PD mimetics MPP+ (a complex I inhibitor) or dopamine. Treatment with these toxins led to dose and time dependent reductions in ATP and glutathione levels and also chymotrypsin-like and postacidic-like …
-
Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
… treatment increased cholesterol synthesis in human Neuroblastoma SH-SY5Y (SHY) and mouse neuroblastoma 2a (N2a) and N2a transfected with human APP (N2a-APP) by up-regulating biosynthesis enzymes including 24-dehydrocholesterol reductase (DHCR24) and 3-hydroxy-3methyl-glutaryl-CoA reductase …
-
DESIGN AND SYNTHESIS OF PURINE BASED NEUROPROTECTORS AND NOVEL SYNTHETIC METHODS FOR THE TRIFLUOROMETHYLATION OF ALDEHYDE HYDRAZONES
… their neuroprotective effects, using SHSY-3Y human neuroblastoma cell line. Through these studies, we have identified purine-based neuroprotector compounds that favorably modulate oxidative stress induced by the Fenton reaction-generated reactive oxygen species (ROS).</p> <p>The …
-
Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
… mu opioid receptor (MOPr) transcripts in SH-SY5Y human neuroblastoma cells. This effect was prevented by the androgen receptor (AR) antagonist hydroxyflutamide. Receptor binding assays confirmed a decrease in MOPr of approximately 40% in nandrolonetreated cells. Treatment with actinomycin D …
-
Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation
… neuronal RNA-binding proteins implicated in human disease are associated with brain polyribosomes, namely the Nova and Hu paraneoplastic antigens and the Fragile X mental retardation protein. We use microarray analysis of polyribosomal mRNAs in knockout mouse models of these diseases to …
-
Vergleichende Analyse der Gerstmann-Straeussler-Scheinker-Syndrom-assoziierten Mutation A117V mit der neuen pathogenen Mutation G114V des humanen Prion-Proteins in vivo und in vitro
… PrP caused strong agglutination and decline of human neuroblastoma cells that might be due to the increased synthesis of transmembrane forms of mutant PrPs as verified using a cell-free topology assay. When proteasomal degradation was perturbed, PrP G114V and PrP A117V revealed enhanced …
-
Synthesis and bio-pharmacological activity of antisense phosphatidyl-oligonucleotides
… on the expression of VEGF at mRNA level in human Neuroblastoma cells. Both the phosphatidyl-tetradecamers were able to inhibit the expression of VEGF mRNA with an effective concentration significantly lower than was found, in parallel experiments, for the corresponding unmodified antisense …
Page 1 of 3