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Showing 1 to 16 of 16 for “"human neural stem cells"”.
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Monoallelic Gene Expression In Human Neural Stem Cells
… reported evidence of widespread autosomal RME in human lymphoblastoid cells (Gimelbrant et al. 2007) and mouse neural stem cells (Wang et al.2010; Li et al. 2012). However, the extent to which RME occurs in human neural tissue is unknown. Using a genome-wide analysis of allele-specific expression …
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Glioma produced periostin attracts human neural stem cells
"Stem cells from various lineages have been well known for their migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms in these processes are not yet known. In the present study, I aimed at identifying the …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
One main goal of stem cell biologists is to efficiently direct stem cells into particular cell fates useful for the treatment or study of neurological disease. Towards that goal, our laboratory has previously developed an in vitro procedure consisting of basic fibroblast growth factor (bFGF), …
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Human neural stem cells: region-specific properties and prospects for cell therapy
Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural …
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BTK functions as a corepressor of Nurr1 in human neural stem cells
Nurr1이 TH 유전자의 발현을 조절할때 세포의 분화정도에 따라 새로운 cofactor를 유도하여 complex를 형성하게되는데 미분화신경줄기세포에서는 BTK를 분화세포에서는 PARP를 유도한다.
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
… A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate to the brain and induce behavioral recovery in mouse intracerebral hemorrhage (ICH) stroke model. However, many of the grafted hNSCs did not survive the transplantation, which may have reduced …
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DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to …
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뇌종양 동물모델에서의 인간신경줄기세포주의 종양으로의 특이적 이주에 관한 입체적 분석
… assays 4 4. In vivo analysis of tumor-tropism of human neural stem cells 5 5. X-gal stain 6 6. Cell count and unbiased stereology in a tumor region of rats 7 7 .Cell count and unbiased stereology in a entire brain of rats 8 8. Labeling of F3 Cells with 5-bromo-2-deoxyuridine 8 9. Hematoxylin and …
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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease
… that can alter the course of the disease. Neural cell death in the striatum and the cortex results from the accumulation of toxic mutant huntingtin protein (mHTT) fragments. Full length HTT is cleaved by proteases, including caspases, calpains and matrix metalloproteinases (MMPs). Previous …
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Characterization of Genes Specifically Expressed in Embryonic and Cancer Stem Cells
ES cells are derived from the ICM of blastocyst and have ability of self-renewal, unlimited proliferation and pluripotency that differentiate into cells of all three germ layers. The stem cell genes such as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc (c-Myc) act alone and interact with …
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MiR-128 controls the activity of Polycomb Repressor Complexes 1 and 2 in Neural Stem Cells: Implications of its loss in gliomagenesis.
… PRC2. PRC activity normally plays a key role in stem cell maintenance, but it is oncogenic in glioblastoma where it is involved in cancer stem cell maintenance and radio-resistance. Here we show that miR-128 directly targets the mRNA of BMI1 and SUZ12, key components of PRC1 and PRC2, …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… due to infiltrating behavior of these glioma cells. Here, author investigated the possibility of treatment for the malignant gliomas with neural stem cell (HB1.F3) transduced with suicidal gene using the tropism of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide …
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Effects of prolonged mitosis on neural stem cells in vivo during development
… 12 microcephaly-linked genes identified in human genetics studies encode microtubule/centrosome-associated proteins and mutations in these genes are strongly tied to disrupted mitotic processes in neural stem cells during cortical development. Yet, how perturbed neural stem cell mitosis …
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Development of Combinatorial Strategies Employing Neural Stem Cells and Polymer Scaffold for Spinal Cord Repair
… of Combinatorial Strategies Employing Neural Stem Cells and Polymer Scaffold for Spinal Cord Repair Stem cell-based therapy holds promise to enhance functional recovery following spinal cord injury (SCI). Most evidence that transplantation of neural stem cells can produce beneficial …
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… (SCI). Although proliferating glial progenitor cells (GPCs) are present in the lesioned spinal cord, spontaneous remyelination is extremely limited. The failure of remyelination after SCI may be due to inadequate signaling to generate sufficient OLs from GPCs. In this thesis research, I tested a …
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Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
Human fetal neural stem cells (hNSCs) may be useful for developing a cell-based therapy to treat spinal cord injury (SCI). In these studies we examined the effects of epigenetic mitogens on proliferation and differentiation of hNSCs in vitro and the outcome of hNSC grafting into contusion injured …