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Showing 1 to 10 of 10 for “"human monoclonal antibodies"”.
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Inhibition of Macrophage Binding and Uptake of OxLDL by OxLDL-Specific Human Monoclonal Antibodies
"목적 : 동맥경화증은 대표적인 관상동맥 심질환중의 하나이다. 동맥경화증은 동맥의 혈관 벽에 콜레스테롤이 축적되고, 여러 면역반응이 관찰되는 염증반응이다. 최근 여러 가지 자가 면역 인자들이 동맥경화증의 개시와 진행에서 중요한 역할을 하는 것으로 밝혀졌다. 산화 저밀도 지질단백질은 이러한 염증반응을 유발하고 지속시키는 주요 자가 항원 중의 하나로 알려져 있다. 본 연구의 목적은 소속연구실에서 동맥경화 환자의 말초 혈핵 단핵세포(peripheral blood mononuclear cells)에서 분리하여 산화 저밀도 지질단백질에 …
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Development of microanalysis tools for characterization of the humoral response to infections diseases
Antibodies are higher order protein structures produced by a subset of lymphocytes (B cells) in the immune system for protection against pathogenic species. These homodimers of heterodimers form highly specific interactions with their cognate antigens and hence have become very important for the …
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Characterisation of Alloantibody-Human Leukocyte Antigen Interactions to Improve Immunological Risk Assessment in Solid Organ Transplantation
… a recipient’s donor HLA-specific antibodies has revolutionised the field of solid organ transplantation. These immunoassays are essential for patient evaluation, immune monitoring, and antibody-related immunological risk assessment, however uncertainties concerning data …
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The role of antibodies in tuberculosis
The role of antibodies in tuberculosis (TB) has been debated for over a century. Antibodies against Mycobacterium tuberculosis (M.tb) are detectable in persons who appear to resist M.tb infection, and yet humoral immune activation is a consistent biomarker of TB disease progression. Antibody …
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Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients
… LDL (oxLDL) may represent a target for autoantibodies involved in the pathogenesis of the disease. The aim of this study was; first, analysis of the Ag-binding characteristics of anti-oxLDL autoantibodies isolated from atherosclerosis patients' PBMC; second, determination of the VH and VL …
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Characterisation of antibody populations in renal dialysis patients : their role in renal transplant outcome
… antiHLA) and/or non-damaging (presumed non-HLA) antibodies. An in vitro assay has been developed which can reliably define the specificity of donor reactive antibodies even in complex mixtures. This technique was applied to define the immunoglobulin class and specificity of antibodies present in …
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Establishing an ex vivo model of acanthamoeba keratitis and investigating the phenotypic similarities between the protozoan acanthamoeba and human macrophages
… species are opportunistic pathogens of humans that cause two main diseases including a potentially blinding infection of the cornea called Acanthamoeba keratitis (AK) in immunocompetent individuals, and a fatal granulomatous encephalitis in the immunocompromised. In this study, an ex …
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Immunhistochemische und zellbiologische Analyse humaner monoklonaler Antikörper gegen kolorektale Karzinome
Drei verschiedene mit Hilfe der humanen Hybridomatechnologie aus einem Rektumkarzinompatienten isolierte humane monoklonale Antikörper wurden immunhistochemisch und mit Hilfe zellbiologischer Tests untersucht. Die Ergebnisse der Immunperoxidasefärbung geben erste Hinweise auf die Art und Verteilung …