Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"human model"”.
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Digital Human Model for Postural Assessment - Postural Visualisation Application
Postural assessment is a vital process that enables clinicians to diagnose abnormalities and suggest treatment to improve a patient’s quality of life. However, the current methods of assessment and practices of data recording are non-standardised and do not utilise the opportunity modern mobile …
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RNA Dysregulation in a Novel Human Model of TDP43 Proteinopathy
… In this thesis, we describe a novel in vitro model allowing on-demand mislocalisation of endogenous TDP43, without its mutation or overexpression. We engineered TDP43-GFP induced pluripotent stem cells, where GFP was knocked into the C-terminus of endogenous TARDBP. In MNs, expression of an …
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An investigation of human-model interaction for model-centric decision-making
This thesis presents an investigation of human-model interaction in relation to model-centric decision-making. Models are abstractions, or simplifications, of reality that humans use to augment their ability to make sense of the world, anticipate future outcomes, and make decisions. This thesis …
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Development and validation of an in vitro human model of drug-induced vascular injury
… preclinically, driving a need to study this in human tissue. The aim of this thesis was to develop and characterise an in vitro human model that would allow the study of DIVI in human tissue during drug development. The first stage was to effectively reproduce DIVI in an animal model. To reduce …
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Designing and Evaluating Object-Level Interaction to Support Human-Model Communication in Data Analysis
… analytic systems that enable users to tweak model parameters directly or indirectly so that they may explore high-dimensional data. To study interactive data analysis, we present an interface, Andromeda, that enables non-experts of statistical models to explore domain-specific, …
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Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems
… for a great deal of the disease outbreaks in human populations. These spillover events are set to continue due to anthropogenic and environmental changes that impact the distribution of these viruses. The viruses in the family Hantaviridae are classified as one of these emerging zoonotic RNA …
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A comparison of digital human model ergonomics outputs driven by optical and inertial motion capture systems in virtual reality
Digital human models (DHM), or virtual human avatars, can be used within digital virtual manufacturing to conduct proactive ergonomics analyses. Recent technological advancements have allowed for dynamic posturing of the DHM using motion capture technology and virtual reality immersion, providing a …
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A computer simulation study of a single rigid body dynamic model for biped postural control.
Existing kinematics models for humans cannot simulate movement beyond geometric constraints. On the other hand, complex dynamics models are computationally expensive for real time computer graphics applications in Virtual Environments(VE). To be able to create a more realistic, real time, and …
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Design of gait rehabilitation system
… the gait rehabilitation system also features a human model with average anthropometric dimensions that allows better visualization and understanding of the actual machine operation. The human model is kinematically coupled to the machine and the whole assembly presents a complex mechanism that …
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Development of an Absorbing Radio Frequency Shield for Safe Magnetic Resonance Imaging
… ARFS shell is designed for a generic head-trunk human model for basic electromagnetic full-wave and thermal validations. A multi-layered ARFS shell structure is proposed, which consists of a highly conducting layer (HCL) embedded in a thick absorbing conductive layer (ACL) and an insulating …
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Immunological analysis of pericardial tuberculosis
Pericardial tuberculosis (TB) offers a relevant human model to study TB at the site of disease and to determine the effect of HIV-1 infection. 96 Patients with pericardial TB were recruited into this study, 68 of whom were HIV-1 infected. Where clinically indicated, pericardiocentesis was performed …
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Modeling Monogenic Diabetes Mody3 Using Human Pluripotent Stem Cells
… diabetes has been challenging due to the lack of human model but also because mouse models do not recapitulate the disease. Here, we use human pluripotent stem cells (ESCs) and CRISPR-CAS9 (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas9) nucleases to understand the most common form …
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3D reconstruction of human body via machine learning
Three-dimensional (3D) reconstruction and modeling of the human body and garments from images is a central open problem in computer vision, yet remains a challenge using machine learning techniques. We proposed a framework to generate the realistic 3D human from a single RGB image via machine …
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Techniques for orientation independent gait analysis
… independent features can be extracted using a human model. The algorithm is developed and tested on live captured data and found to perform better across orientations than silhouette based approaches. The performance recorded at a single orientation is lower than that of other approaches, …
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Bio-Surfaces and Geometric References for a Standardized Biomechanical Design Methodology for Mass Customization
… of customizable products that interface with the human body. The method presented involves first, a consistent method of capturing and representing the human model so that the model can be used with CAx tools and solid modeling techniques. Second, it provides a design methodology based on feature …
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Developing an a-synuclein in vitro model for therapeutic testing for Parkinson's disease
… In this thesis, I aim to create a more relevant human model of PD for studying α-synuclein pathogenesis, drug testing, and therapeutic approaches. Chapter One: provides a background, rationale, and literature review on α-synuclein's involvement in PD, and its *in vitro* modelling. Chapter Two: …
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INDUCED PLURIPOTENT STEM CELL DERIVED LIVER MODEL FOR THE STUDY OF PNPLA3-ASSOCIATED NON-ALCOHOLIC FATTY LIVER DISEASE
… due in large part to the lack of a comprehensive human model of PNPLA3-associated NAFLD. In order to address this need, we have developed an in vitro model that takes advantage of the unique properties of human induced pluripotent stem cells (hiPSC) and the CRISPR/CAS9 gene editing technology. We …
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Modelling of Whiplash Trauma Parametric study of rear-end impacts using FEM and CFD
This work is a combination of Finite Element (FE) modelling and Computational Fluid Dynamics (CFD) to investigate the effect of acceleration pulses, head restraint and seating posture on facet joint loads and pressure transient magnitudes on the neck injury outcome during whiplash motion. A …
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Bayesian Relevance for Enhanced Human-Robot Collaboration
… a difficult yet critical component for seamless Human Robot Collaboration (HRC). As robots become increasingly involved in helping humans with a variety of tasks, ranging from part assembly to healthcare and more, it is crucial to model and understand human intention. Many works still do not take …
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Slow Touch and Fast Nociception: Exploration of the Interactions Between Noxious and Innocuous Mechanical Touch Sensation
Human cutaneous somatosensation is a multimodal physiological process by which physical stimuli on the body surface activate neural substrates that consequently give rise to perceptions such as pressure/vibration, temperature, itch, and pain. When considering skin mechanosensation, the canonical …
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