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Showing 1 to 5 of 5 for “"human metabolic syndrome"”.
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Differentielle hepatische Genexpression in einem Mausmodell mit polygener Adipositas, Insulinresistenz und Hyperglykämie
New Zealand Obese (NZO) mice exhibit a polygenic syndrome of morbid obesity and insulin resistance, that resembles the human metabolic syndrome. In order to define its biochemical basis, the differential expression of genes involved in hepatic glucose and lipid metabolism was studied. An outcross …
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Identifikation und Charakterisierung von Suszeptibilitätsloci für Adipositas und Hypercholesterinämie in der NZO-Maus
… genes responsible for obesity and the associated syndrome of insulin resistance, hyperglycemia and dyslipidemia, and to compare the effects under a standard and a high fat diet. The pattern of symptoms presented by the NZO mouse closely resembles the human metabolic syndrome, suggesting a common …
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Identifizierung und Charakterisierung von Suszeptibilitätsloci für Typ-2-Diabetes mellitus in einem Mausmodell für das Metabolische Syndrom
New Zealand Obese (NZO) mice exhibit a polygenic syndrome of morbid obesity, insulin resistance, and arterial hypertension that resembles the human metabolic syndrome. In addition, adult NZO-males are severely hyperglycemic and hypoinsulinemic. In order to localize the genes responsible for this …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… and NEIL1 KO mice display symptoms of the human metabolic syndrome such as obesity, dyslipidemia, and fatty liver disease. These observations lead us to develop the working hypothesis that NEIL1 is involved in a preferential repair pathway for oxidized base damage in the replicating genome …
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Microarray-basierte Expressionsanalysen des weißen Fettgewebes der NZO-Maus sowie der Langerhansschen Inseln der NZL-Maus : zwei Modelle für das metabolische Syndrom
… NZL-Mäusen, zwei polygenen Mausmodellen für das humane metabolische Syndrom, durchgeführt. Eine kohlenhydrathaltige Hochfett-Diät (HF: 14,6 % Fettanteil) führte in beiden Mausmodellen zu früher Adipositas, Insulinresistenz und Typ 2 Diabetes. Eine fettreduzierte Standarddiät (SD: 3,3 % …