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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"human mesenchymal stem cells"”.
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Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
Mesenchymal stem cells, harvested from adult bone marrow, are promising in the field of regenerative medicine because of the vast differentiation potential into various cell lines such as: osteoblasts, chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells …
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Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions
Stem cells have become increasingly important in the biomedical field because they have the potential to invade and regenerate damaged tissue. In particular, the bone marrow contains meesenchymal stem cells (MSCs) that have the capacity to differentiate into many cell lineages. The incorporation of …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
Human mesenchymal stem cell (hMSC) is adult stem cell that is useful tool for a various disease. However, it has limitations that lost proliferation and differentiation ability in long-term in vitro culture and occurred senescence. This study would like to confirm the relationship between Wnt …
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Factors affecting neurogenesis after application of human mesenchymal stem cells in ischemic rat model
… trial of ex vivo culture expanded autologous mesenchymal stem cells (MSCs) in patients with severe ischemic stroke. We proposed that an optimal condition, for either donor or recipient, may exist and enhance the effects of the mesenchymal stem cells in those patients. Thus we evaluated the …
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Effects of Mild Heating on the Osteogenic Differentiation of Human Mesenchymal Stem Cells during Inflammation
… chronic inflammation that can obstruct healing. Mesenchymal stem cells have great potential to be used as part of a novel therapy for bone and cartilage regeneration. They are a highly regulated, self-renewing population of cells with potent mechanisms to avoid allogeneic rejection, offering …
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Controlling Tissue Matrix Assembly of Human Mesenchymal Stem Cells toward Engineering Native-like Bone, Cartilage, and Osteochondral Grafts
… assembly from a clinically relevant cell source, human mesenchymal stem cells, towards generating native-like tissue properties has been demonstrated. The investigational approach was crafted around three specific aims: controlling the matrix assembly of bone mineral (Aim 1), articular cartilage …
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An in vitro evaluation of tyrosine derived polyarylates and polycarbonate as polymeric scaffold for human mesenchymal stem cells osteogenic differentiation
Human mesenchymal stem cells (hMSCs) obtained from the adult bone marrow are multipotential cells that are capable of differentiating along several lineages. They are readily available and abundant source of cells in the field of tissue engineering. For their use in treating certain connective …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… result in permanent functional loss of damaged cells. Many researchers have looked for methods that will reduce secondary brain damage since there is no effective therapeutics to recover functional loss of damaged tissues. The severity of the secondary mechanism of TBI depends upon two factors: …
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Characterisation of STRO-1 expression on human mesenchymal stem cells and identification of putative cancer stem cells in osteosarcoma: prevention by micronutrients
… increasingly more common to use culture expanded human mesenchymal stem cells (hMSCs) in regenerative medicine due to their low incidence in vivo. However, their successful application is hampered by a lack of selective markers to positively identify the expanded multipotent cells. This study …
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Effect of Melatonin on Differentiation of Human Mesenchymal Stem Cells and a Study on C-Terminal Domains of MT1 and MT2 Melatonin Receptors
… the melatonin treatment that would differentiate human mesenchymal stem cells (hAMSCs) into osteoblasts. A 21 d continuous melatonin treatment significantly increased the alkaline phosphatase (ALP) activity and the deposition of calcium in hAMSCs. These effects were inhibited by MT2 specific …
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Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
Many clinical and animal studies of mesenchymal stem cells (MSCs) transplantation in ischemic stroke and several neurodegenerative diseases have shown the beneficial effects on functional recovery and inhibition of disease progression. In our previous study, intra-cerebral transplantation of …
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Neuronal Differentiation and Functional Recovery after Transplantation of Human Mesenchymal Stem Cell in The Ischemic Rat Model
… disease, Huntington's disease and Stroke. Human mesenchymal stem cells are pluripotent stem cells, which can be differentiated into mesenchymal lineage cells. Those cells from the individual patient have the advantage to minimize the immune rejection. In this study, cytokine-inducted human …
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Effect of platelet factors and thrombin on multiplication of human bone marrow mesenchymal stem cells cultured in low and high oxygen level in vitro
… In the bone marrow, hematopoietic and mesenchymal stem cells form a unique niche, in which oxygen tension is low. Hypoxia may have a role in maintaining stem cell capacity for self-renewal and multipotency. We have shown previously a positive influence of platelet-derived growth factors …
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APPLICATION OF POLYETHYLENE-GLYCOL LINKED MULTI-WALLED CARBON NANOTUBES FOR IMPROVED STEM CELL DIFFERENTIATION
… DIRECT THE SKELETAL MYOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS (HMSCS), EVEN IN THE ABSENCE OF MYOGENIC INDUCTION FACTORS. TO ENHANCE THE MYOGENIC DIFFERENTIATION OF HMSCS, WE DESIGNED AND FABRICATED A PEG-CNTS COATED POLY-ACRYLAMIDE HYDROGEL WITH CLOSE STIFFNESS TO HUMAN MUSCLE …
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Characterization of Genetically Modified Mesenchymal Stem Cells with a Retroviral Vector Expressing a Suicide Gene
Human mesenchymal stem cells have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases because they have the capability to migrate into tumor or lesion sites. Previously, we showed that mesenchymal stem cells could be utilized as a cellular …
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… the mechanical and bio-chemical inputs to our system, we controlled the dynamics of microvascular network formation as well as key properties of the network morphology. These findings will aid in the design and engineering of organ specific constructs for tissue engineering and regenerative …
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The synergistic effect of pulsed electromagnetic fields and demineralized bone matrix on the osteogenic differentiation of mesenchymal stem cells
… bone matrix (DBM). In the present study human mesenchymal stem cells (hMSCs) were seeded on DBM scaffolds in the presence of PEMF to determine if an increased osteogenic response could be induced. hMSCs were harvested from scaffolds at 5, 7, 14, and 21 days and osteogenic differentiation …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… engineering. The present in vivo study evaluates human umbilical cord derived vascular endothelial cells (HUVEC) or hematopoietic stem cells(HSCs)-mediated formation of microvascular networks in a biocompatible PCL-ßTCP hybrid scaffold in an immuno-compromised nude mouse. The PCL-ßTCP scaffold …
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Regulated release of a novel non-viral gene delivery vector from electrospun coaxial fiber mesh scaffolds
… constructs that can support the proliferation of cells and stimulate their differentiation into functional tissues. With that in mind, biocompatible polymers were fabricated into a novel gene delivery agent as well as three dimensional scaffolds that act as reservoirs and controlled release …
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A MULTISCALE APPROACH TO STEM CELL-BASED CHONDROGENESIS FOR CARTILAGE REPAIR
… of microfabrication and soft-lithography. Human mesenchymal stem cells (hMSCs) were selectively seeded in these channels. The chondrogenic potential of hMSCs seeded in these channels was investigated. We demonstrate selective seeding of viable hMSCs within the channels. hMSC aligned and …
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