Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"human mRNA"”.
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Direct Recruitment of eIF4GI and/DAP5 to the 5' UTR of a Subset of Human mRNA Drives Their Cap-independent Translation
… cap-dependent translation initiation pathway in human cells is suppressed by sequestration of the cap-binding protein, eukaryotic initiation factor(eIF) 4E, by 4E-binding proteins. Circumvention of cap-dependent translation shutdown has been linked to tumor development and cancer progression. The …
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BIOINFORMATICS INVESTIGATION OF RNA PSEUDOKNOTS
… readthrough, recoding mechanisms in viral and human mRNAs. To meet the specific needs of the bioinformatics investigations, a new algorithm and method for the detection of RNA pseudoknots has been developed. The new approach differs from all existing pseudoknot detection programs in that it is …
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The Role of the Human Nuclear Poly(A) Binding Protein in RNA Decay
… can stimulate transcript decay in the nucleus of human cells, a function mediated by the ubiquitous nuclear poly(A) binding protein PABPN1. We show that PABPN1 is required for the degradation of a viral nuclear noncoding RNA as well as an inefficiently exported human mRNA. Importantly, the …
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Messenger RNA Destabilization by -1 Programmed Ribosomal Frameshifting
… genomic sequences, and suggested a role in mRNA stability. This work improves and extends the computational methods used to search for potential -1 PRF signals. It continues to examine four yeast -1 PRF signals and show that they promote significant mRNA destabilization through the nonsense …