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Showing 1 to 5 of 5 for “"human lymphoblastoid cell lines"”.
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Cytogenetic Evaluation Of Low Dose Hyper-Radiosensitivity In Human Lymphoblastoid Cell Lines Exposed To Cobalt-60 Gamma Radiation.
<p>The dose-effect relationships of cells exposed to ionizing radiation are frequently described by linear quadratic (LQ) models over an extended dose range. However, many mammalian cell lines, when acutely irradiated in G2 at doses below 30 cGy, show hyper-radiosensitivity (HRS) as measured by …
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Bystander Effects Due To Neutrons, And Low-Dose Hyper-Radiosensitivity To Gamma Rays In Human Cells Using Cytogenetics
… micronucleus assay in two normal human lymphoblastoid cell lines exposed to neutrons or gamma radiation. Micronuclei, nucleoplasmic bridges and nuclear buds were enumerated by recording the coincident presence of these endpoints within individual cells, and the associations among …
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Identifying a transcriptional signature for cell sensitivity to the cancer chemotherapy agent, BCNU
… and exogenous agents. These mechanisms activate cell cycle checkpoints to allow time for DNA repair or, in the case of severely damaged DNA, initiate cell death mechanisms to maintain genomic integrity. The cell's response to DNA damaging agents includes wide spread changes in the transcriptional …
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Mechanisms of apoptosis modulation and their contribution to genomic instability in tumor cells
The concept of programmed cell death has been increasingly considered from various aspects since early 1970’s. Primarily, knowledge of apoptosis referred to morphological changes in which chromatin is condensed and increasingly fragmented, revealed as small structure in the nucleus. The membrane …