Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"human lungs"”.
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Hyperpolarized noble gas magnetic resonance imaging of human lungs in 150G magnetic field
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.
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Understanding mechanisms of, and risk factors for, lung injury in the critically ill
… the pattern of lung injury in porcine and human lungs ventilated using injurious settings in an ex-vivo lung perfusion (EVLP) model, and I evaluated whether lung injury was transferrable from VILI to control lungs. Additionally, A549 cells were cultured in human EVLP perfusate and the …
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Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
… is a great need for research models that mimic human lung physiology and lung pathologies such as chronic lung diseases and respiratory infections. The morbidity and mortality associated with lung disease and respiratory infections represent a global burden. Pathogenesis of these diseases and …
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Field evaluation and health assessment of air cleaners in removing radon decay products in domestic environments
… and deposition of radon decay products in human lungs are recognized as producing a significant health risk. Air cleaners are one of the mitigative methods that remove radon decay products rather than radon itself. Currently, there are still uncertainties about the health benefit of air …
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A Theoretical Exploration of the Growth and Stability of Alveolospheres
… structure which resembles the alveoli in human lungs. In recent years, they have become increasingly popular as model systems for disease research and treatment development, especially with the onset of COVID-19. Patients born with a rare mutation on both copies of their SFTPB genes face …
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Development of a Lung Surrogate Model for Assessing Biomechanical Responses to Underwater Explosions (UNDEX)
… was designed to mimic the mechanical behavior of human lungs, utilizing thermoplastic elastomers (TPE) and polyurethane foam to replicate the elastic and porous nature of lung tissue and alveolar sacs. Material characterization tests were conducted to simulate quasi-static deformation through …
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Studies of Lung Micromechanics via Hyperpolarized 3He Diffusion NMR
While high quality MR Images of lungs are difficult to obtain with conventional proton MRI due to the organ's low tissue density, the advent of techniques in noble gas polarization have enabled MR investigations of the lung's more abundant air space rather than its tissue. In addition to …
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Numerické simulace transportu a depozice vláken v zjednodušeném modelu dýchacích cest
… MMMFs (man-made mineral fibers) are harmful to human health when inhaled because of their abundance in the atmosphere, composition, and ability to penetrate deep into human lungs. It can cause lung cancer and numerous other diseases according to the severity of the exposure. To address this …
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Studies of Polycyclic Aromatic Hydrocarbons in Urban Atmospheres
… and are consequently capable of penetrating to human lungs as far as the alveoli. The recoveries of PAH from scot, when exposed to NOx, decrease with time at rates which correlate with molecular properties. Hence even in the absence of photolytic degradation a chemical route exists whereby the …
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Development Of A Unified Approach (An Index) To Study The Particulate, Carbon Monoxide Emissions And The Combustion Efficiency Using Field And Laboratory Investigations
… therefore they interact with a large area of the human lungs. Therefore, surface area monitor was used to study the surface area of the particles emitted during combustion. Although it showed low PM2.5 concentration, high surface area was observed in some instances. Kerosene stove which appears to …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
… acid (UDCA), downregulates ACE2 in human lung, cholangiocyte and intestinal organoids and in the corresponding tissues in mice and hamsters. I also show that UDCA-mediated ACE2 downregulation reduces susceptibility to SARS-CoV- 2 infection in vitro, in vivo and in human lungs and …
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Point mutations in normal lungs of smokers and non-smokers
… environmental mutagens play an essential role in human somatic and germinal cell mutagenesis. In particular, the finding of small amounts of chemical mutagens in cigarette smoke has led to the general hypothesis that mutagens in cigarette smoke induce oncomutations and thus account for the …
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Role of scavenger receptor MARCO in particle uptake and lung inflammation
… into a fibrotic response called silicosis in the human lungs. Previous studies have indicated the role of membrane glycoproteins called scavenger receptors in binding of environmental particles. The scavenger receptors are classified into different classes (A-H) based on their structure and …
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Role of scavenger receptor MARCO in particle uptake and lung inflammation
… into a fibrotic response called silicosis in the human lungs. Previous studies have indicated the role of membrane glycoproteins called scavenger receptors in binding of environmental particles. The scavenger receptors are classified into different classes (A-H) based on their structure and …
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Exploration of B cell diversity in the human lung
… aware of the presence of a microbiome within the human lung. The constant presence of microorganisms requires a regulated immune system that can differentiate between infectious organisms and non-infectious commensals. B cells in the lungs are a key member of adaptive immunity by producing antigen …
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
Respiratory disease is a growing threat to human health worldwide. Induced pluripotent stem cell (iPSC) based stem cell therapy is promising for end-stage respiratory disease patients. Generation of mature/functional lung cells from iPSCs heavily relies on understanding of human lung development. …
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Characterization of Atmospheric Particulate Matter in Mountaintop Mining and Non-mining Areas in West Virginia with Known Health Differences
… (PM), which is associated with environmental and human health effects. Environmental studies of air and water quality in southwest West Virginia provide evidence of air contamination and surface and ground water contamination around coal mining areas, including mountaintop mining (MTM) sites. …
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A study of gene expression in human normal and carcinogenic cell lines using qRT-PCR
The susceptibility of human lungs to carcinogens depends on the metabolic balance between activation and detoxification pathways, though for the tumour to develop depcnds on activation of cell immortalisation pathway. The correlation of these pathways has not been reported. The present study …
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Computational models for respiratory gas exchange and their applications
The primary function of the lungs is the transport and exchange of oxygen and removal of carbon dioxide that is critical in supporting normal function of vital body organs. Various modelling studies have attempted to investigate and capture aspects of the gas exchange process and its regulation …
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Cell Fate Decisions in the Developing Lung
… at the alveoli. Throughout gestation the lungs are filled with fluid, but at the moment of birth this fluid is expelled and lungs must be competent to function for gas exchange and enable breathing (Szoták-Ajtay et al., 2020). Research has suggested that a multipotent progenitor population …
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