Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"human lung development"”.
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
Respiratory disease is a growing threat to human health worldwide. Induced pluripotent stem cell (iPSC) based stem cell therapy is promising for end-stage respiratory disease patients. Generation of mature/functional lung cells from iPSCs heavily relies on understanding of human lung development. …
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Investigating factors governing cell fate decisions in respiratory epithelium
… and repair and its construction during embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are unknown, particularly in human lung development. Multiciliogenesis describes the …
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The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells
… of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells Recent work in the developing human lung has identified distal tip epithelial progenitors that are SOX9+SOX2+ and give rise to all lung epithelial cell types (Danopoulos et al., 2019b; Miller et al., 2018; …
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Hypoxia signalling regulates human lung epithelial cell fates
Human embryos develop in an environment with low oxygen tension (< 5% O2) during the first trimester. Hypoxia substantially impacts mammalian development and tissue homeostasis. However, it remains unclear whether and how hypoxia directly affects human lung epithelial development. In this PhD …