Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"human keratinocytes"”.
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RegulationofGap Junction Protein,Connexins in Immortalized Human Keratinocytes Cells(HaCaTcells)
… communication in cholesteatomas remains unknown. Human middle ear cholesteatomas showed more increased expression of Cx43 and Cx26 than retroauricular skins. In another study for making in vitro 3 dimensional model of cholesteatomas, there was some difference of epithelial characteristics between …
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Estrogen receptor involvement in the response of human keratinocytes to ultraviolet B irradiation
… growth, senescence, and apoptosis to protect keratinocytes. Additional signaling due to E2-activation of the estrogen receptor may provide back-up or redundant pathways in response to UVB.
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Effects of arsenic and UVB radiation on induction of cyclin D1 in human keratinocytes.
… epithelial cancers. Arsenic metabolism in humans leads to its collection in the skin, where it encounters and can act with known carcinogen UVB. Epidemiological evidence of the two toxins demonstrates their potential to affect signaling pathways, with various consequences. Here we employ an …
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The Use of Sphingomyelin to Protect Against UV Induced DNA Damage in Human Keratinocytes
… we present the use of SM for UV protection of human keratinocytes (KRTs) to prevent DNA mutations that result from UV exposure. In particular, analysis of the expression of DNA damage biomarkers p21 and p53 was done to determine the potential of SM to prevent DNA damage associated with UV …
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Assessing the Photoprotective Effects of Fluorescent Sphingomyelin Against UVB Induced DNA Damage in Human Keratinocytes
… potential by reducing p21 and p53 levels in keratinocytes (KRTs) after UV radiation [13], [14]. This thesis aims to expand on past BSM research by exploring the mechanism for photoprotection. Normally, sphingomyelin (SM) is metabolically degraded to ceramide which then leads to cell apoptosis …
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Characterizing the motogenic response of human keratinocytes to epidermal growth factor and transforming growth factor-alpha
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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The Impact of Cutaneous Papillomavirus and Interferon Regulatory Factors on Interferon Expression in Canine and Human Keratinocytes.
North Carolina State University Theses Veterinary Medical Sciences.
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Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments
… requires the interaction between epithelial (keratinocytes) and mesenchyme cells. Attempts to recapitulate the process of hair induction in wounded skin in vitrousing human cells have to date been unsuccessful. The aim of this project is to attempt to elicit the early steps of hair follicle …
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
… resulting in TGF-β resistance. While normal human keratinocytes (HKc) and human papillomavirus type 16 immortalized HKc (HKc/HPV16) are sensitive to the growth inhibitory effects of TGF-β, HKc/HPV16 gradually develop resistance to TGF-β as the cells progress in vitro to a differentiation …
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The Role of Tyrosine Kinase Growth Factor Receptors in Psoriatic Epidermal Hyperplasia: Analysis of Growth Factor Synergy in Cultured Human Keratinocytes and Receptor Expression in Psoriatic Skin
… in normal and psoriatic skin. Growth of normal human keratinocytes in a chemically defined medium demonstrated that IGF-I, EGF, or basic FGF (bFGF) alone did not support significant keratinocyte spreading or proliferation. Considerable proliferation was observed when IGF-I was added in …
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Do heavy ions induce the bystander effect? : study to determine the induction of the bystander effect from Fe ion beam compared to X-rays in human keratinocytes
… effect was studied in hTERT immortalized human keratinocytes. Cells are plated in a 6-well plate and in a companion permeable membrane insert. Cells in the 6-well plate are irradiated using conventional 250 kVp X-rays or 1000 MeV/nucleon Fe ion beam, LET of 151 keV/pm, from the NASA Space …
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Gene transfer of keratinocytes with a human Factor XIII - plasmid construct
… was the transient liposomal transfection of human keratinocytes with the gene for clotting factor XIII and the analysis of the protein expression for a future in vivo use for wound healing. Human keratinocytes were cultured in vitro with serum free medium. At 80% confluence liposomal …
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The role of translation in keratinocyte cell fate determination.
… helping to maintain tissue homeostasis. Cultured human keratinocytes generate a range of colony sizes, but can be separated into two groups based on the ratio of outcomes after cell division. On average, ‘balanced’ colonies give rise to equal numbers of proliferative and differentiating cells, …
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Stochasticity and order: studies of keratinocyte proliferation
… The wide range of colony sizes in cultured human keratinocytes has been taken to support this hypothesis. Contrary to this model, researchers using genetic lineage tracing in mouse epidermis have inferred a single progenitor population for homeostasis, and a quiescent stem cell population …
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Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix
… between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is also capable of causing severe invasive disease …
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The Role of Gram - Negative Anaerobes in Hidradenitis Suppurativa
… robust inflammatory profile generated in normal human keratinocytes by these GNAs. These GNAs elicit a strong IL17-dependent pathway response not seen in gram-positive bacteria and likely driven by IL-17C production. Overall, the magnitude of production of cytokines is much greater in all GNAs, …
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
… in many normal tissues, including epidermal keratinocytes, and has a critical role in UV-induced apoptosis. However, PKC-delta is frequently lost in chemically or UV-induced mouse skin tumors, as well as in human cutaneous squamous cell carcinomas (SCC). Furthermore, re-expression of …
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Der Retinoidmetabolismus in HaCaT-Zellen
… to its active metabolite Retinoic Acid. HaCaT keratinocytes were used in our study as an example of a human non-malignant keratinocyte cell line. This immortal cell line is well characterized and is frequently used as a paradigm for skin keratinocytes in vitro because of its highly preserved …
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Nanoparticelle per la terapia dei tumori: preparazione, caratterizzazione e tossicità
… aspect. The culture of three different types of human cell phenotypes is accurately described in the second part. For our experiments, we decided to cultivate human melanocytes, a human melanoma cell line, and human keratinocytes. Melanocytes appeared characterized by a dendritic-like morphology, …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
… molecular effects of HYP-PDT on normal primary human keratinocytes (Kc), melanocytes (Mc) and fibroblasts (Fb) in an in vitro tissue culture model thus representing both the epidermal and dermal cellular compartments of human skin.
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