Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"human intestine"”.
-
The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
… metabolites but low levels of free EL in human plasma. Hepatocytes and enterocytes express UDP-glucuronosyltransferases (UGT), the enzymes responsible for the conjugation of glucuronic acid to EL. To better understand the contribution of liver and intestine to the first-pass …
-
Creation of organoid systems to model human endodermal organ development in vitro
… limited attempts to use the technology to study human organ development. The work of this thesis established two novel hepatic organoid systems; one based upon the archetypal liver stem cell, the hepatoblast, whilst the other was based upon a hitherto undescribed biliary progenitor cell. The work …
-
A 3D in vitro model of the human gut-microbiome. A bioelectronics approach.
Over the past decades, the human gut microbiota has emerged as a key player in the bidirectional communication of the gut-brain axis, affecting various aspects of health and disease. Although a vast array of studies have revealed the specific role of gut microbiota in various physiological and …
-
Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
… intestinal epithelial organoids, a model of the human intestine. This system is well established and has been shown to be comparable to in vivo intestinal tissue in many ways. However, my study revealed DNA methylation (DNAm) is generally lost and becomes more variable the longer organoids are …
-
Growth and Viability of Bifidobacterium Bifidum in Cheddar Cheese
… maintaining a healthy normal microflora in the human intestine and prevent enteropathogens from colonizing. The presence of LAB in the intestine promotes the production of the B vitamins and is also believed to activate the immune system and inactivate toxic compounds (22). Bifidobacteria were …
-
Small intestine slow wave activity defined through in vivo high-resolution electrical mapping
The small intestine is characterised by underlying rhythmic bioelectrical potentials that propagate along the organ in a coordinated fashion; these propagating biopotentials are termed slow waves, and they serve a vital role in the regulationand organisation of intestinal motility. Most previous …
-
Human intestinal cells across space and time
Cells of the human intestinal tract undergo dynamic changes from development to adulthood and in response to environmental stimuli. Recent advances in high-throughput profiling of cells using transcriptomic approaches have vastly expanded the catalogue of cells that are found across the human body. …
-
Composition and Dynamics of the Plasma Membrane of Entamoeba Histolytica
… It has specifically adapted to growth in the human intestine and has retained or evolved several unique biochemical pathways. Furthermore, E. histolytica displays several interesting phenomena, including immune avoidance and contact dependent cytotoxicity, which have yet to be explained. …
-
Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… mitigate the negative consequences of a damaged intestine, and reduce the need or intensity of costly supportive therapies. Attaining nutrients is a careful orchestration of diet, digestion, and absorption. In a typical “Western” diet, approximately half the calories are derived from …