Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"human induced pluripotent stem cell-derived cardiomyocytes"”.
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Contractile Properties of Striated Muscle in Development and In Disease
… development and disease at the protein, subcellular, and cellular level. Distal arthrogryposis is a skeletal muscle birth defect that can be caused by a mutation in embryonic myosin; herein, I have found that the continued muscle dysfunction is linked to a delay in relaxation, likely from …
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Effects of the MYH7 R369Q Dilated Cardiomyopathy-causing Mutation on Myosin Crossbridge Kinetics and Cardiomyocyte Contractility
… of this mutation on the contractile system within a cardiomyocyte that results in hypocontractility. To better understand the biochemical and biophysical effects of R369Q mutation, this study utilized CRISPR/Cas9-edited R369Q homozygous human induced pluripotent stem cell-derived …
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Gatekeeper Connexin43 Phosphorylation Events Regulate Cardiac Gap Junction Coupling During Stress
… reside within the intercalated discs connecting cardiomyocytes, effecting not only direct intercellular electrical coupling, but the localization of other junctional structures and ion channels. Alterations in Cx43 expression occur in essentially all forms of heart disease and is therefore a …
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Engineered Heart Tissues for Advanced Disease Modeling
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are a powerful, in vitro tool for investigating cardiac pathologies. Although hiPSC-CMs have a relatively immature phenotype compared to primary adult cardiomyocytes, their physiological relevance can be improved by …
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Arrhythmogenic mechanisms of acute cardiac infection
… phase involves viral-mediated remodeling of subcellular structures in the myocardium, which is thought to contribute to arrhythmogenesis. The chronic phase is immune response-mediated, where the host immune system causes damage that induces gross remodeling of the heart, which can result in …
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Biochemical effects of organophosphorous compounds on cultured rat and human cardiomyocyte-like cells
… of organophosphorous compounds (OPs) on cardiomyocytes. The present study aimed to investigate the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos), and their acutely toxic metabolites (diazoxon and chlorpyrifos oxon) on rat …
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Development of cardiac patches using medium chain length polyhydroxyalkanoates for cardiac tissue engineering
… (films, random and aligned fibres) by growing human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) on them. The cells were found to be viable and healthy with comparable beating rates and calcium transients to that measured on gelatin which was used as the positive control. The …
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Studies on the role of GPR55 in cardiovascular physiology and pathophysiology.
… (LPI) in cultured rat neonatal ventricular cardiomyocytes provokes distinct cellular functions that are dependent on the location of GPR55, leading to suggestions that GPR55 may regulate cardiomyocyte function at two cellular sites and be a potential therapeutic target for cardiac disorders. …
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Investigating viral subversion of intercellular communication
… directly couple the cytoplasms of apposed cells enabling immunological, metabolic, and electrical intercellular communication. The gap junction protein connexin43 (Cx43; gene name – GJA1) is the most widely expressed human connexin protein and is the predominant connexin in the working …
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Effects of GATA4-targeted compounds in hypertrophic models of hypoplastic left heart syndrome cardiomyocytes
Synnynnäiset sydänviat kehittyvät sydämen kehityksen aikana ja määritellään syntymähetkellä läsnä oleviksi sydämen rakenteellisiksi poikkeavuuksiksi, joista vasemman sydänpuoliskon vajaakehittyneisyysoireyhtymä (HLHS) edustaa harvinaista mutta hengenvaarallista alatyyppiä. HLHS:lle on ominaista …