Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"human immunodeficiency virus type 1"”.
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Purification of Human Immunodeficiency Virus Type 1 Preintegration Complexes by Velocity Gradient Centrifugation.
The early events of human immunodeficiency virus type 1 (HIV-1) infection are mediated by two large nucleoprotein complexes (NPCs), the reverse transcription complex (RTC) and the preintegration complex (PIC). These complexes are responsible for the conversion of viral RNA into viral DNA, transport …
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Human immunodeficiency virus type 1 diversity in patients initiating treatment in Northern South Africa
… and increase in CD4+ cell counts to healthy human ranges. This in turn is expected to reduce HIV transmission thereby, leading to a decreased spread of the virus and eventual elimination of the virus from the human population. Findings from these trials resulted in the near global adoption of …
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Interactions of human immunodeficiency virus type 1 with mucosal epithelial surfaces and Candida albicans
… cell lines are able to transfer viable virus from their surface to permissive cells, (iii) epithelial cells are responding to HIV-1 with changes in intracellular signalling or gene expression profiling, and (iv) Candida albicans can affect epithelial susceptibility to HIV-1 or whether it …
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Mutational studies in the dNTP binding pocket of human immunodeficiency virus type 1 reverse transcriptase
It was earlier postulated that Gln 91 of HIV-1 RT stabilizes the side chain of Tyr 183 via hydrogen bonding interaction between 0(H) of Y1 83 and CO of Q91 (Harris et al., BIOCHEMISTRY 37: 9630, 1998). In an attempt to understand the function of Gln 91 in the catalytic mechanism, mutants of this …
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The Elucidation of the Mechanisms of CD8+ T Cell-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication
… response is comprised of 3 key components, the virus, the effector cell and the target cell, each of which contribute to noncytolytic suppression. During the course of CNAR, the effector cells express antiviral factors that induce intracellular events in the target cell resulting in …
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Characterization of genotypic and phenotypic properties of transmitted Human Immunodeficiency virus type 1 variants circulating in Mbeya Tanzania
Includes abstract. Includes bibliographical references.
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Human immunodeficiency virus type-1 distribution in South Africa and the relevance of genetic diversity on vaccine design
… immune response in mice to a South African subtype C gp120. To investigate the relationship between subtype and mode of transmission, samples were collected from individuals infected by heterosexual and male homosexual transmission from patients attending local HIV/AIDS clinics in Cape Town …
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The role of crude saliva and purified salivary mucins in the inhibition of the Human Immunodeficiency Virus type 1
… are urgently required. Transmission of the virus through an exchange of saliva is rarely known to occur. The role of saliva and its mucus in this inhibition requires clarification. This project sought to verify the previous findings in our laboratory (Habte et al. , 2006; Peacocked et al. …
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Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
… responsible for Lyme Disease and Acquired Immunodeficiency Syndrome (AIDS). The first chapter focused on antigenicity analysis of the VlsE protein in <em>Borreliella</em> bacteria. Conserved regions of VlsE were identified, and two of them were chosen for antibody development due to their …
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The effect of reduction, trypsin digestion and de-glycosylation of salivary mucins in the inhibition of human immunodeficiency virus type 1
… 36.7 million people worldwide were living with Human Immunodeficiency Virus (HIV) and of that total, 1.8 million people were new infections. Sub-Saharan Africa was recognized as the most afflicted regions worldwide accounting for 26 million people, 68%, living with HIV. The difficulty in …
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Single Molecule Imaging of Human Immunodeficiency Virus Type-1 (HIV-1) Envelope Glycoprotein Dynamics Identifies Viral Elements Contributing to Infectious Particle Assembly
<p>The Human Immunodeficiency Virus Type-1 (HIV-1) has remained highly prevalent across the world for over 40 years, taking lives by attacking the immune system. There remains a lack of universal treatment options, which can be attributed to a poorly understood process in the life cycle of the …
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Recombinant Salmonella enterica serovar Typhimurium vaccine vector expressing green fluorescent protein as a model antigen or human immunodeficiency virus type 1 subtype C Gag
Includes bibliographical references (leaves 172-200).
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