Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 510 for “"human immunodeficiency virus"”.
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Genetic characterization of human immunodeficiency virus from Northern South Africa
Globally, human immunodeficiency virus type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development, diagnosis and therapy. Since HIV-1 M group began its expansion in humans roughly 70 years ago it has diversified rapidly now comprising a number …
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Developmental Resilience to Dopaminergic Vulnerability Associated With Human Immunodeficiency Virus
… that corresponds to the periadolescent period of human development, suggest an age-related shift in the vulnerability of midbrain dopamine systems to the neurotoxic effects of HIV.</p>
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Platinum and palladium complexes as human immunodeficiency virus latency reversal agents
The Persistence of latent HIV-1 provirus and reservoirs presents a formidable challenge in human immunodeficiency virus (HIV/AIDS), numerous efforts have been made to develop vaccines and chemotherapeutic agents. However, an effective vaccine remains elusive, and existing HIV/AIDS medications do …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime exposure to these agents. We performed a cross sectional observation of mtDNA levels in whole blood in a pediatric population to ascertain the relationship between mtDNA, NRTI …
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Influence of Human Immunodeficiency Virus and other risk factors on tuberculosis
… over the last two decades mainly because of the Human Immunodeficiency Virus (HIV) epidemic. Globally, it was estimated that 73% of the TB cases were co-infected with HIV with more than 25% of this global co-infection burden being in South Africa alone. In 2012, globally 1.3 million deaths …
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Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children
… data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). Aim: To investigate the evolution of CXR abnormalities in HIV-infected children in LMIC's, to correlate this with the severity of HIV-disease, and to …
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
Human immunodeficiency virus 1 (HIV) infects myeloid cells in the central nervous system (CNS) and establishes a reservoir that persists despite antiretroviral therapy (ART). Infection leads to a 30-50% risk of developing HIV-associated neurocognitive disorders (HAND), a collection of mood, motor, …
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Purification of Human Immunodeficiency Virus Type 1 Preintegration Complexes by Velocity Gradient Centrifugation.
The early events of human immunodeficiency virus type 1 (HIV-1) infection are mediated by two large nucleoprotein complexes (NPCs), the reverse transcription complex (RTC) and the preintegration complex (PIC). These complexes are responsible for the conversion of viral RNA into viral DNA, transport …
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The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1)
Objectives: The primary objective of this study was to assess whether active tuberculosis (TB) accelerates the course of HIV-1 infection by measuring progression to AIDS and mortality in HIV-infected patients. Secondary objectives were to evaluate whether TB should be considered an AIDS-defining …
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Human immunodeficiency virus type 1 diversity in patients initiating treatment in Northern South Africa
… and increase in CD4+ cell counts to healthy human ranges. This in turn is expected to reduce HIV transmission thereby, leading to a decreased spread of the virus and eventual elimination of the virus from the human population. Findings from these trials resulted in the near global adoption of …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
Human immunodeficiency virus infection is a chronic condition causing significant changes in the immune system, which are reflected in the altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the …
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