Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 49 for “"human immune system"”.
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Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
T cells play a central role in the development of immune responses. Patients lacking T cells due to genetic defects such as DiGeorge or Nezelof's syndrome and individuals infected with the human immunodeficiency virus are highly susceptible to infections and cancers. The lack of adequate in vivo …
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Using humanised mice to understand Plasmodium falciparum growth and development
… interactions that can be explored in-vitro. Humanised mice (HuMice) are immunodeficient mice that can be engrafted with human cells and tissues. They are the only small animal model that can be used to study human restricted P. falciparum in-situ and may provide a unique opportunity to model …
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Systems immunology frameworks link multicellular immune perturbation phenotypes and setpoints to response outcomes
… thesis develops frameworks for using top-down systems biology approaches with multiomic single cell technology to understand variation in human immune system response outcomes. We integrate human population, cell subset and single cell variations in molecular phenotypes which give rise to …
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Analysis of the molecular interplay between Streptococcus pyogenes and its human host
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. …
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Immunology based methodology for detecting and searching anomalies
… occurring in the normal functioning of a system. A related problem is search for the occurrence of a specific event from a set of large type of possible events. A brute force search or detection of anomalies is computationally expensive. The current research aims at developing a …
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Untersuchungen HLA-Klasse II-assoziierter, T-zellvermittelter Autoimmunität im humanisierten SCID-Mausmodell des Pemphigus vulgaris
Pemphigus vulgaris (PV) is a severe bullous autoimmune skin disease which is caused by autoantibodies against an epidermal adhesion protein, desmoglein 3 (DG3). The underlying cellular mechanisms in the pathogenesis of PV are not yet completely understood. PV is associated with particular HLA class …
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Aptamer Interactions and Applications in Cancer Treatment
… apoptosis of the MEAR cancer cells. In the human breast cancer cell line MCF7, the MUC1-5TR aptamer is shown to successfully initiate the classical complement pathway leading to complement fixation on the target cell via a streptavidin-C1q conjugation. This model provides a way to help the …
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Algorithms for Understanding and Fighting Infectious Disease
… is a persistent and substantial threat to human health, with consequences that include widespread mortality, suffering, and economic disruption. This thesis presents several algorithmic advances that, when coupled with biotechnologies for data collection and perturbation, are aimed at …
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Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice
… mimicked key aspects of viral pathogenesis and immune response. In this regard, new advances with humanized mice(hu-mice), constructed by engrafting human tissues and cells and harboring a functioning human immune system, have been of great value in advancing research with human viruses Here we …
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Cholesterol-Dependent Cytolysins and Perforin: Similar Pore-Forming Mechanisms in Pathogenic Attack and Human Immune Defense
… proteins present from the bacteria to the human genera. Cholesterol-dependent cytolysins (CDCs) are a family of toxins that participate in bacterial infection pathway at the membrane level. Great interest in this family is due to their similarity, in structure and in pore-forming mechanism, …
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NK Cells and Their Role in Disease and Cancer Treatment
… killer (NK) cells are a crucial part of the human immune system. They play an important role in fighting and controlling viral infections as well as killing cells that have transformed into tumors. NK cells are involved in the pathogenesis of a number of diseases and in this thesis we will …
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A self-healing framework to combat cyber attacks. Analysis and development of a self-healing mitigation framework against controlled malware attacks for enterprise networks.
… framework that takes inspiration from the human immune system. The designed self-healing framework utilises the key characteristics and attributes of the nature’s immune system to reverse botnet infections. It employs its main components to heal the infected nodes. If the healing process …
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Implication des hormones de croissance et du système CD95/CD95-ligand dans la tolérance fœto-placentaire
… placental growth hormone (hPGH) on the maternal immune system. We mainly performed a preliminary study of these effects in the man and in the non-pregnant woman in order to transpose the obtained results to the pregnant woman. We have also analyzed the expression of the hGH-N receptor, which can …
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Distress detection
… It is partly inspired by the workings of the human immune system, that is capable to respond against previously unseen infections. The premise is that within the scope of an attack objective (the attack's end result), attack HTTP requests are associated with features that are necessary to …
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Molecular and Biochemical Characterisation of SiaP as a Sialic Acid Binding Protein Component of a TRAP Transporter of Sialic Acid.
… in the growth and persistence of the obligate human mucosal pathogen Haemophilus influenzae, which causes respiratory tract infections, septicaemia and meningitis. Like many other bacteria, H. influenzae can use host-derived sialic acids as carbon, nitrogen and energy sources, but also as a …
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Inactivation of Allergenic Proteins by Compressed Carbon Dioxide
… allergenic disease risks by activating human immune system. These allergens are known indoor risk factors for some sensitive individuals, especially for children under age 13. Avoidance and effective protecting protocols from Der p 1 and Fel d 1 call for serious attention. It has been …
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Structural studies of HIV-1 Vif and its SOCS-box domain
The human immunodeficiency virus type I (HIV-1) is a retrovirus that damages the human immune system, which is suppressed by a cellular factor APOBEC3G in non-permissive cells. The viral infectivity factor (Vif) can induce a poly-ubiquitination degradation of APOBEC3G to counteract the immune …
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Using machine learning to increase the predictive value of humanized mouse models for the human immune response to YFV-17D
Despite their utility as models for human systems, intrinsic differences between mouse and human biology limit direct translation of findings. Immunocompromised mice have been engrafted with functional human immune system components, or “humanized”, to better model the human immune response. …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
… importance of studying poxvirus effects on the human immune system, reports of the direct interactions between poxviruses and primary human leukocytes (PHLs) are limited. We studied the specific molecular events that determine the VV tropism for major PHL subsets including monocytes, B cells, …
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Synthetic strategies for potential trypanocides
Human African trypanosomiasis (sleeping sickness) is a devastating disease which is endemic in parts of sub-Saharan Africa. It is caused by the protozoan parasite T. brucei, which are transmitted by the bite of infected tsetse flies. Although the disease is fatal if left untreated, there is a lack …
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