Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"human herpesvirus"”.
-
Human herpesvirus 6 in multiple sclerosis and encephalitis
Human herpesvirus 6 (HHV-6) was identified from patients with HIV and lymphoproliferative diseases in 1986. It is a β-herpesvirus and is divided into two subgroups, variants A and B. HHV-6 variant B is the cause of exanthema subitum, while variant A has not yet definitely proven to cause any …
-
Genetic divesity of Human Herpesvirus Type 8 in Northern South Africa
Background: Human herpesvirus type 8 (HHV-8), is an oncogenic virus responsible for causing all forms of Kaposi`s sarcoma (KS). HHV-8 prevalence varies globally, however, it is more prevalent in African countries, with South Africa having over 50% of HHV-8 infections. HHV-8 encodes a highly diverse …
-
The role of heterochromatin markers in lytic human herpesvirus egress and maturation
The human herpesviruses are large, double-stranded DNA viruses known for their persistent latent phase. Within the herpesvirus family there are 3 subfamilies; alphaherpesviruses, classified as such because of their more rapid replication and latency in neurons; betaherpesviruses, known for slow …
-
Systematic Enhancement of Human Herpesvirus 6A Reconstitution: Bridging Technical Refinement and Host Determinants of Virus Replication
Human herpesvirus 6A (HHV-6A) is a betaherpesvirus that presents substantial challenges for research due to its strong propensity for latency and slow replication. This thesis addresses the critical bottleneck of efficient recombinant HHV-6A reconstitution from bacterial artificial chromosome (BAC) …
-
Seroepidemiologic, Laboratory and Diagnostic Studies on the Spread of Some Human Herpesvirus Infections in Northeast Bulgaria /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението на някои човешки херпесни вирусни инфекции в Севеоизточна България
При изследване на 1846 единични серумни проби от случайно подбрани лица с използване на няколко метода (CFT, NT, ELISA, IFA) установихме широко разпространение носителството на антитела спрямо 5 човешки херпесни вируси във Варненски и Добрички региони (HSV1, HSV2, VZV, HCMV, EBV). Средната …
-
Development of protein microarrays for the investigation of host-pathogen interactions
Varicella-Zoster virus (VZV) is a human herpesvirus (causing chickenpox and shingles upon reactivation) whose diagnosis is particularly important in pregnancy and immunocompromised patients. Current sérodiagnostic assays are either based on crude whole cell lysates or glycoprotein preparations …
-
KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
Kaposi's Sarcoma-Associated Herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is a tumorigenic herpesvirus tightly linked with various human malignancies including Kaposi's Sarcoma, Primary Effusion Lymphomas (PELs), and Multicentric Castleman's Disease. Immunocompetent individuals infected with …
-
Interazioni tra le glicoproteine D, B, H ed L critiche per la fusione indotta dal virus Herpes simplex
… Chimeric gB molecules composed of HSV and human herpesvirus 8 (HHV8) sequences failed to reach the cell surface and to complement a gB defective virus. By means of pull down experiments we analyzed the interactions of HSV-HHV8 gB chimeras with gH or gD fused to the strep-tag. The gB …
-
Translational initiation controls localization and regulatory function of the gamma-herpesviral protein kaposin
Kaposi's Sarcoma Associated Herpesvirus (KSHV) or Human Herpesvirus-8 (HHV-8) is the most recently identified human gamma-2 herpesvirus and has been implicated in Kaposi's Sarcoma (KS) and primary effusion lymphoma (PEL). At the right end of the genome KSHV encodes the complex kaposin locus, which …
-
Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection
… Sarcoma Herpes Virus (KSHV), also known as Human Herpesvirus 8 (HHV8), is the etiological agent of Kaposi Sarcoma (KS) and other lymphoproliferative cancers, such as Multicentric Castleman’s Disease (MCD), Primary Effusion Lymphoma (PEL), and a newly discovered rare disease called KSHV …
-
Investigating the Role of Human Cytomegalovirus Protein LUNA in Regulating Viral Gene Expression during Latency
Human cytomegalovirus (HCMV) is a widespread human herpesvirus pathogen and prototypical member of the β-herpesvirus subfamily. Like all herpesviruses, the virus establishes a lifelong latent infection following host exposure, which has the potential to reactivate periodically and contribute to …
-
EBV-Associated Gastric Cancer: From Initial Infection to Unique Therapeutic Approaches
<p>Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that infects over 95% of the adult population. While infection is typically asymptomatic, in some individuals, particularly the immunocompromised, EBV is the causative agent of several cancers including lymphomas and epithelial cancers. …
-
Investigating the Unique Mechanism of Action of CADA Analogs for Down-Modulating CD4, Sortilin, and ACE2
… has been found to inhibit the replication of human immunodeficiency virus (HIV) and human herpesvirus type 7 in cell cultures. It works by down-modulating human CD4 (hCD4) and blocking co-translational translocation of the nascent protein across the endoplasmic reticulum (ER) membrane, which …
-
Structural and functional characterisation of pUL21, an α-herpesvirus phosphatase adaptor protein
… simplex virus 1 (HSV-1) is a very prevalent human herpesvirus that causes life-long infection and is known to dramatically remodel the cellular environment upon replication. This extensive manipulation is achieved using only a limited number of virus-encoded proteins, many of which possess …
-
Investigating the Role of Viral Long Non-Coding RNAs During Human Cytomegalovirus Latency
Human Cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. Primary infection with HCMV in healthy individuals is generally asymptomatic but the virus is never cleared and can go on to establish lifelong latency in cells of the early myeloid lineage. During latency, the virus reduces its gene …
-
CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
Epstein-Barr virus (EBV) is a human herpesvirus that infects more than 95% of the world’s population by adulthood. Like other herpesviruses, EBV has a biphasic infection cycle which includes latent and lytic programs. Upon primary infection, the virus establishes a lifelong latency in memory B …