Global ETD Search
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Showing 1 to 4 of 4 for “"human gastrulation"”.
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Cell Memory and Fate in Human Development
… which includes vertebrates, occurs during gastrulation when cells are directed into one of three primary germ layers. Model systems, including frog, fish, chicken, and mouse, have been very useful for uncovering the identity and function of the key signaling networks driving vertebrate …
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WNT signalling in the patterning of human gastruloids
The study of early human development poses a challenge due to technical and ethical limitations, particularly during the initial four weeks following fertilisation. During this critical period, the fundamental aspects of the body plan are established through a process known as gastrulation, which …
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The Role and Control of WNT Signalling in an HESC Model of Human Primitive Streak
<p>In amniotes, gastrulation is marked by the creation of the primitive streak (PS) and is largely controlled by WNT, BMP, and ACTIVIN/NODAL signalling. Despite detailed characterization in model organisms, the human PS and the role these pathways play in its formation and patterning remains a …
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NOGGIN Transport in a Model Human Epiblast
<p>Using self-organizing human models of gastrulation, the Brivanlou/Siggia labs previously showed that (i) BMP4 initiates the cascade of events leading to gastrulation; (ii) BMP4 signal-reception is restricted to the basolateral domain; and (iii) in a human-specific manner, BMP4 directly induces …