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Showing 1 to 13 of 13 for “"human erythrocyte"”.
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Identification of Novel Allosteric Regulators of Human Erythrocyte Pyruvate Kinase
Erythrocyte pyruvate kinase (R-PK) is a key glycolytic enzyme catalyzing the transphosphorylation of phosphoenolpyruvate (PEP) and ADP to pyruvate and ATP respectively3,4. The substrate PEP and product pyruvate of this reaction are involved in a number of energetic and biosynthetic pathways; hence …
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The water permeability of the human erythrocyte in the temperature range +25CÌ to -10CÌ
Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
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The kinetics and thermodynamics of human erythrocyte freeze-thaw damage at sub-optimal cooling rates.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1977.
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Covalent Binding and other Mechanisms of Primaquine Toxicity
… decreased the glutathione content of liver and erythrocytes, possibly through the formation of reactive metabolites.</p> <p>The NADPH-induced peroxidation of lipid of mouse mi crosomes and human erythrocyte membranes were markedly inhibited by PQ and 5H6DPQ (a PQ derivative), respectively. In …
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Simple and facilitated diffusion in rat erythrocytes
… late nineteenth century, workers chose to use erythrocytes due to their advantages over using a variety of cell types. With erythrocytes a comparison could be developed between strictly homologous cells of many different species. Erythrocytes are easily obtainable and mature cells are separate …
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Biochemical Studies Of Human Hyperuricaemia
… of normal controls has been used for comparison. Human erythrocyte phosphoribosylpyrophosphate synthetase (2.7.6.1.) was found to be much more stable in all samples than has been reported. Kinetic parameters for this enzyme, using a modified assay, were identical in individuals from the three …
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Synthesis and structure-activity relationship studies of novel anti-infectives for cross screening in tuberculosis and malaria disease models
Some 12-16 hours after the invasion of the human erythrocyte by the malaria parasite Plasmodium falciparum, there appear in the erythrocyte membrane ‘new permeability pathways’ which mediate an increased permeability of the infected cell to a range of low molecular weight solutes, including anions, …
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Proteome-wide Functional Profiling of Serine Hydrolases in the Human Malaria Parasite
… in eukaryotes and prokaryotes. The most virulent human malaria parasite Plasmodium falciparum has over 40 predicted serine hydrolases (SH). Prior investigation on a few of these have suggested their critical role in parasite biology. The majority of the SHs in P. falciparum have not been …
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Aspects of purine and pyrimidine metabolism
… a review of the literature concerning aspects of erythrocyte membrane transport and metabolism, and purine and pyrimidine metabolism is presented. The effects of pH, pO₂ and inorganic phosphate (Pi) on the uptake and metabolism of hypoxanthine by erythrocytes has been studied in Chapter 2. Uptake …
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Fragments of the human antimicrobial LL-37 and their interaction with model membranes
… characterization of two fragments of LL-37, a human antimicrobial peptide from the cathelicidin family. The fragments LL-32 and LL-20 exhibited contrary behavior in biological experiments concerning their activity against bacterial cells, human cells and human cancer cells. LL-32 had even a …
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Purine transport in plasmodium falciparum
… purines into Plasmodium falciparum-infected erythrocytes were measured using classical uptake techniques. We found that the uptake of purine into intact parasite-infected erythrocytes was mediated by the endogenous human erythrocyte nucleoside and nucleobase transporters (hENT1 and hFNT1) …
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New approaches to understanding the interactions between Plasmodium falciparum merozoites and human erythrocytes during invasion
… parasite stage that is released from infected erythrocytes (merozoite), being able to invade a human erythrocyte and muliply. Invasion is a complex process involving multiple receptor-ligand interactions and multiple steps. It begins with attachment of the parasite to the erythrocyte, followed …