Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"human endothelial cells"”.
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Vitamin E and arachidonic acid metabolism in cultured human endothelial cells.
… approach to study the metabolism of nutrients in human cells was developed. The incorporation and depletion of 2R,4$\sp\prime$R,8$\sp\prime$R-$\alpha$-tocopherol (RRR-$\alpha$-T), a natural form of vitamin E, and its subsequent effect on the metabolism of arachidonic acid were conducted on human …
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Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells.
… processes or injury to the endothelium lead to endothelial dysfunction and the initiation and progression of certain diseases such as the development of atherosclerosis as well as micro and macro-angiopathy (De Caterina et al. 2000). In the present study, we examine the effect of glucose and …
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Influence of the Atrial Natriuretic Peptide on TNF- αα α -activated human endothelial cells
… chemokines (MCP-1), and cytoskeleton changes in human endothelial cells. 5.1.1 Effect of ANP on TNF- α αα-induced CAM expression The following diagram shows a schematic outdraw of the summerized results of the first part of the present work. figure 1 summary: schematic diagram of the signal …
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Effect of Fatty Acid Modification on Prostacyclin Production in Cultured Human Endothelial Cells (Arachidonate, Elcosapentaenoate)
An endothelial cell culture system was used to compare the effects of endogenous arachidonic acid (AA) and eicosapentaenoic acid (EPA) on prostacyclin synthesis. Supplemental levels of fatty acids (20-150 (mu)M) were supplied as sodium salts bound to bovine serum albumin (3:1 mole ratio) and added …
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Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis.
… risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative stress in mediating Hcy atherogenic effects. The aim of this study was …
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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
… stress generated by blood flow may regulate endothelial cell expression of blood clot dissolving proteins or vasoactive proteins, an in vitro perfusion system was used to expose human umbilical vein endothelial cell monolayers to well defined, laminar fluid flow. Protein production studies …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… which is a coreceptor for BMP9 and BMP10. Endothelial-specific, homozygous deletion of Eng in adult mice (Eng-iKOe) has been shown to model the HHT phenotype, with the development of arteriovenous malformations (AVMs) in the pubic symphysis, associated high-output heart failure, via …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… been shown to produce productive infection of endothelial cells in vitro with no visible cytopathic effects which provides a unique opportunity to study the cells while they are infected. Here, we show that direct Junín virus infection of primary human endothelial cells (EC) corresponds to …
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Physicomechanical Response of Ionic Polyurethanes on Endothelial Cells
… graft material to analyze the response of human endothelial cells and correlate it to cell-matrix interactions. We propose to use polycaprolactone-based ionic PU and design a composite (blend) of cationic and anionic PUs to modulate the physicomechanical properties. PUs are designed with …
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Synthesis, biological activity and mechanism of atypical carotenoid antilipoperoxidants
… proposed to be a causative factor in a myriad of human diseases. However, identifying a causative mechanistic role of lipid peroxidation has proven challenging and the role of oxidized lipids in disease pathogenesis remains enigmatic. We posited that a potent small molecule inhibitor of lipid …
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Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events
… systems to define the responses evoked in endothelial cells exposed to hemodynamic waveforms characteristic of coronary collateral vessels and the subsequent paracrine effects on smooth muscle cells. Initially, a lumped parameter model of the human coronary collateral circulation was used …
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Localized Excitation Fluorescence Imaging (LEFI)
… nondestructive imaging of fluorescently labeled cells through a thick and optically opaque vascular scaffold, contained in a bioreactor. This imaging modality is based on local excitation of fluorescent cells, acquisition of fluorescence through the scaffold, and fluorescence mapping based on the …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… manner by modulating the function of interendothelial adherens junctions. The permeability-inducing effects of these cytokines appear to occur independently of nitric oxide production since inhibition of iNOS does not prevent cytokine-mediated increases in permeability. Additionally we have …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… driven by vascular inflammation that begins with endothelial dysfunction. The endothelium, which lines blood vessels, plays a critical role in regulating vascular tone and immune cell interactions. In response to inflammatory stimuli, such as cytokines, endothelial cells become activated, …
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Autophagy and Inflammation During Rickettsial Infection
… bacteria that replicate in the cytoplasm of host cells. In my dissertation, I have studied the induction of autophagy by rickettsiae as well as the role of autophagy in the pathogenesis of rickettsioses in vitro and in vivo. I found that autophagy is induced in murine bone marrow macrophages …
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Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
… relevant size, metabolically active cells far from a nutrient source undergo necrosis when starved of oxygen and vital nutrients, but the incorporation of microvasculature would allow the production of functional tissues larger than 200 µm, the diffusion limit of oxygen through …
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