Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 298 for “"human diseases"”.
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Signatures of gut microbes in human diseases
The human body constitutes a complex ecosystem inhabited by a vast and diverse community of microorganisms. Through evolution, host-microbe interactions have been shaped toward mutually beneficial relationships that support host health. Consequently, perturbations of the microbial compartment are …
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Targeting T Cells for the Immune-Modulation of Human Diseases
… underlies the pathogenesis of a myriad of human diseases ranging from cancer to autoimmunity. As coordinators, executers and sentinels of host immunity, T cells represent a compelling target population for immune-modulation. In fact, the antigen-specificity, cytotoxicity and promise of …
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STRUCTURE-BASED COMPUTATIONAL MODELING OF PROTEIN-LIGAND INTERACTIONS - APPLIED TO PROTEINS INVOLVED IN HUMAN DISEASES
… performed against an important cancer target, human kidney-type glutaminase, which identified novel binders that manifest inhibition potential.
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ZEBRAFISH (DANIO RERIO) AS A MODEL SYSTEM FOR THE FUNCTIONALVALIDATION OF CANDIDATE GENES FOR HUMAN DISEASES
… increasingly utilized as a model for studying human gene functions and associated diseases. This has been possible due to the very high conservation of genes and of organs and systems which are fully functional within the very first days of embryonic development. The easy and efficient genetic …
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An inducible, conditional and targeted B cell ablation mouse model for studying B cell functionality in the pathogenesis of human diseases
… model for investigating the pathogenesis of human diseases such as hepatitis and systemic lupus erythematosus (SLE). Conditional and targeted cell ablation is a powerful approach for studying cellular functions in vivo. However, currently available cell ablation models still have some …
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Genes: Multigene Families, Control of Gene Expression, Genetic contributions to Human Diseases, including Chromosomal Fragile Sites and ‘Dynamic’ and ‘Non-self’ Mutations
… to determine gene function and / or to model human genetic disease pathogenesis, specifically pathogenic mechanisms of the protein WWOX in cancer and expanded repeat RNAs in neurodegenerative diseases. The culmination of this recent work is the development of an hypothesis – 4. that expanded …
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Investigating the genomic distribution and potential contribution of retrotransposable elements in relation to their potential impact on genome function and predisposition to human diseases.
… impact on genome function and predisposition to human diseases. Randa Aweis Ali Active retrotransposable elements (RTEs) provide a continuous source of genomic diversity in humans. The potential impact of a novel RTE insertion depends on its genomic location. Previous studies investigating the …
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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms
… the field for many years. Recently, advances in human induced pluripotent stem cell (iPSC) technology has enabled the study of uniquely human diseases, such as AD, in human tissue. However, the inability to precisely and efficiently genetically engineer human iPSCs has limited their use in …
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Linking Biomolecular Condensates to Disease and Therapeutic Development
… likely contribute to condensate dysregulation in human diseases (Banani et al., 2022). Pathogenic mutations in condensate-promoting features span diverse disease classes across both Mendelian diseases and cancers. FDA-approved small molecule therapeutics interact with condensates, selectively …
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Power Analysis and Extension of a Robust Test of Linkage and Association of Human Complex Disease Genes
… is a modern approach for gene mapping of complex human diseases, the Transmission/Disequilibrium Test (TDT). My studies demonstrate that the TDT is a robust, nuclear family based analysis that can test linkage in the presence of association. I show the advantages and disadvantages of the TDT in …
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Small molecules that imperfectly replicate protein function of missing proteins restore physiology in yeast and human epithelia
Human diseases caused by an excess of protein function can often be treated with small molecules that bind and inhibit the corresponding proteins. In contrast, there are many currently incurable human diseases that are caused by missing protein ion transporters, including cystic fibrosis and …
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High Dimensional Analysis of Genetic Data for the Classification of Type 2 Diabetes Using Advanced Machine Learning Algorithms
… of genetic-based determinants in common complex human diseases. To date, 120 single nucleotide polymorphisms (SNPs) for T2D have been identified using GWAS. Standard statistical tests for single and multi-locus analysis, such as logistic regression, have demonstrated little effect in …
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Learning on the Graph: Link Prediction, Multi-label Learning, and Applications to Integrative Complex Disease Studies
<p>Most of the common human diseases, such as cancer, diabetes, and Alzheimer's disease, are consequences of the abnormality of multiple cellular components and the perturbation of their intricate interactions. The emerging network-based approaches offer a unique framework for understanding the …
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Innovative formulations for the treatment of Plasmodium infections
… is the most traditional method used to treat human diseases and solve health problems. Their combination represents the future prospective to a better care of human health. Considering the importance of nanomedicine and the natural origin of many current malaria therapies, in this thesis, …
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Algorithms And Tools For Computational Analysis Of Human Transcriptome Using Rna-Seq
… regulating gene expression, and more than 90% of human genes are alternatively spliced through different types of alternative splicing. Dysregulated alternative splicing events have been linked to a number of human diseases. Recently, high-throughput RNA-Seq technologies have provided …
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Unlocking thePadlock: Elucidation of Protein Arginine Deiminase 4 Function, Activity and Activation Dynamics
… increasingly apparent as its putative roles in diseases becomes more evident. Enormous effort has been made towards understanding the physiological roles of these protein modifying enzymes, in particular, PAD4, due to the increasing evidence linking dysregulated PAD activity to the incidence and …
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Analysis of Zinc Transporters in C. elegans
… a major role and are implicated in a variety of human diseases. However, the mechanisms by which zinc transporters coordinate to regulate zinc homeostasis in whole animals and by which they are related to human diseases are not well understood. To address these questions, we used C. elegans as a …
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Development of Dendrimer-based Technologies for Phosphoproteomics and Glycoproteomics in Biomarker Discovery
… linked to the onset and progression of various human diseases. Our lab has been focusing on developing novel and more efficient technologies by taking advantage of the properties of dendrimers – a soluble nanopolymer with chemically well-defined structure and functional surface groups – to …
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Human Mutation/substitution Rate: Variability, Modeling And Applications
… for discovering causal genes and variants behind diseases or making inferences about evolutionary processes. Human mutation rate varies significantly across the genome although most studies have only considered the immediate flanking nucleotides around the polymorphic site to model and study …
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Structural and biochemical characterization of nuclear pore complex structural scaffold sub-complexes
… transport mechanisms and various pathologies and human diseases associated with deletions or mutations of constituents. To obtain detailed structural information of the NPC, techniques that span several resolution ranges are necessary due to its large size and complexity. For instance, recent …
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