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Showing 1 to 20 of 57 for “"human cytomegalovirus"”.
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Human Cytomegalovirus and the Neutrophil
Human cytomegalovirus (HCMV) is a highly prevalent opportunistic infection and a major pathogen in immune-compromised patients. The virus exhibits a wide cell tropism and is able to lytically infect virtually any cell type, with detectable gene expression and release of new virions, but not the …
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Natural Killer Cell Responses to Human Cytomegalovirus
Human cytomegalovirus (HCMV), a member of the beta-herpesvirus family, establishes latent infection in the face of robust humoral and cell-mediated immune responses. In spite of significant efforts, the mechanisms implicated in protective immunity during HCMV infection are still not fully …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a betaherpesvirus that infects most humans worldwide. In the healthy host, it elicits a broad immune response involving both the innate and adaptive arms of immunity, which is able to limit viral replication and prevent end-organ disease. However, like all …
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Analysis of human cytomegalovirus in the healthy human carrier
… blood leukocytes as one site of persistence of Human Cytomegalovirus (HCMV) in healthy carriers. However, the exact population of peripheral blood cells that carry HCMV and to what extent they express HCMV gene products in not known. I have examined the sites of HCMV persistence in the …
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Characterization of the Human Cytomegalovirus UL75 Late Gene Promoter
… expression during productive infection by the human cytomegalovirus (HCMV) occurs in an ordered and sequential manner, beginning with immediate early (IE), then early (E) and finally late (L) gene expression. Significant work has addressed the regulation of IE and E gene expression while …
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Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that infects a majority of the human population. Like other herpesviruses, HCMV readily establishes a latent infection that persists for the lifetime of the host and undergoes periodic lytic reactivation events. In healthy individuals, HCMV …
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Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
Human cytomegalovirus (HCMV) is a ubiquitous and clinically significant herpesvirus, causing substantial morbidity and mortality in immunocompromised individuals and congenital infection in up to 1/100 pregnancies. HCMV has evolved a myriad of strategies to evade the host immune response, including …
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The Role of Viral Protein pUL21a in Human Cytomegalovirus Infection
The double-stranded DNA virus human cytomegalovirus: HCMV) is a ubiquitous human pathogen that causes severe disease in immunocompromised individuals and neonates. The biology of HCMV remains largely undefined and functions of many of the roughly 200 putative HCMV genes are still unknown. One of …
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Analysis of two hypervariable human cytomegalovirus genes, UL146 and UL139
Human cytomegalovirus (HCMV) is a highly host-specific, ubiquitous herpesvirus that results in asymptomatic infection for the majority of those infected. However, it produces serious clinical disease in neonates and immunocompromised individuals such as transplant recipients and AIDS patients. The …
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Understanding and Exploiting Viral Protein US28 During Human Cytomegalovirus Latency
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus which infects 50-100% of humans worldwide. HCMV causes a lifelong subclinical infection in immunocompetent individuals, but is a serious cause of mortality and morbidity in the immunocompromised and in neonates. Like other herpesviruses, HCMV …
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Human Cytomegalovirus Us17 Locus Fine-Tunes Innate And Intrinsic Immune Responses
<p>HCMV employs numerous strategies to combat, subvert, or co-opt host immunity. One evolutionary strategy for this involves "capture" of a host gene and then its successive duplication and divergence, forming a gene family, many of which have immunomodulatory activities. The HCMV US12 family …
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The roles of human cytomegalovirus US27 gene product during virus infection
<p>Human cytomegalovirus (HCMV) is a widespread pathogen that causes lifelong latent infection. Successful persistence of HCMV in healthy individuals involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors …
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Characterisation of Novel Autophagy and Necroptosis Antagonists Encoded by Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes significant morbidity and mortality in immunocompromised individuals. To support its intracellular survival, HCMV has evolved diverse strategies to manipulate key host pathways and evade intrinsic immune defences. In this thesis, …
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The Association of the Human Cytomegalovirus Genome with the Cellular Nuclear Matrix
… of the major immediate early gene (MIE) of the human cytomegalovirus (HCMV) has been analyzed for its capability of fulfilling criteria defining nuclear scaffold/matrix attachment regions (S/MARs). These criteria are: 1) binding the nuclear matrix in an in vitro nuclear matrix binding assay; 2) …
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Comparison and Correlation of Four Methods of Measuring Immunity to Human Cytomegalovirus
… used to determine the presence of antibody to human Cytomegalovirus (CMV). Several more recent techniques have now been adapted for this purpose. A comparison of CMV antibody titers was made between the CF test, a commercially available enzyme-linked immunosorbent assay (ELISA), an indirect …
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THE HCMV INTERACTOME: A QUANTITATIVE ANALYSIS OF HUMAN CYTOMEGALOVIRUS-HOST PROTEIN INTERACTIONS
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects the majority of the adult population. Similarly to other herpesvirus, it is able to enter a state of latency, persisting within the host for life. Infection of healthy individuals is normally asymptomatic, however it is among the …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
Human cytomegalovirus (HCMV) is a betaherpesvirus that establishes a lifelong infection in hosts. In the majority of cases, the immune response to primary HCMV infection limits viral replication and dissemination, such that overt clinical disease is prevented. However, the immune system cannot …
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The effect of human cytomegalovirus on neutrophil survival, autophagy, and extracellular traps
… to benefit from neutrophil effector functions. Human cytomegalovirus (HCMV) is a clinically important pathogen that infects the majority of the human population. Monocytes are considered the main vehicle of HCMV dissemination throughout the body, but little research has been done on its …
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