Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"human coronaviruses"”.
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Host Entry Factors for Human Coronaviruses
<p>Coronaviruses infect a diverse range of animals from birds to pigs and cats to humans. Coronaviruses employ RNA-based replicative processes and as such are genetically adaptable to acquire novel host ranges. A coronavirus from one species can jump to another by shifting its entry requirements. …
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INFECTION- AND VACCINE-INDUCED IMMUNE RESPONSES TO SARS-COV-2 AND OTHER HUMAN CORONAVIRUSES
… cross-reactivity between pre-existing anti- human adenovirus 5 (HuAd5) and ChAdOx1-nCoV-19 vaccine vector immunity, with ChAdOx1-nCoV-19 vaccination inducing HuAd5 specific T cells and antibodies in vaccinated humans and in a mouse model. In the human study, ChAdOx1-nCoV-19-induced spike-T …
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Receptor Binding Domains and Coronavirus Adaptation and Evolution
Coronaviruses are enveloped RNA viruses that cause respiratory diseases in humans and other animals. The continued circulation of human coronaviruses and the large reservoir of non-human coronaviruses that have the potential to infect humans represent a significant health concern. Similar to other …
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Cloning and expression of the M-gene from the human coronavirus NL-63 in different expression systems
… (e.g. rhino-, influenza-, parainfluenza, human metapneumo-, respiratory syncytial-, adeno- and coronaviruses), the cause of a substantial portion, (48-70%) of cases remain unidentified (Van der Hoek et al, 2004; Fouchier et al, 2004; File, 2003; Fine et al, 1999; Shay et al, 1999, …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
Human coronaviruses (HCoVs) have garnered intense interest due to the large outbreaks caused by severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which have …
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Dissecting Host-Viral Interactons Through Focused or Unbiased High-Throughput Genetic Approaches
… million million—times as many viral particles as humans on earth (1). While most of these viruses do not cause disease in humans, those that do present a grave and increasing threat to human health. Fundamental studies in host-viral interactions are thus critical to further our understanding of …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… receptor variants identified in the genomes of human patients with rare cardiovascular diseases recruited to the NIHR BRIDGE project. The V38L, T89M, and R168H variants showed distinct effects on apelin receptor pharmacology. V38L reduced receptor localisation at the membrane, but was able to …
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The burden of human coronavirus infection in children hospitalized with severe lower respiratory tract infection in Cape Town, South Africa (2012-2013)
… better understand the epidemiology and burden of human coronaviruses - NL63, HKU1, OC43 and 229E in South Africa, their role in the aetiology of childhood pneumonia needs to be described. Methods: We used data collected between September 2012 – September 2013 from children aged < 13 years with …
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Exploring multivalent technologies and strategies for directed protein evolution
… specificities towards a range of pathogenic human coronaviruses. As such, insight into the potential of occupied sequence space with overlapping fitness optima towards different distantly related targets for the subsequent evolution of broadly specific interactions could be obtained. The …
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Antibody production with synthetic peptides against human Coronavirus-NL63 ORF3 protein
Human Coronavirus (HCoV) NL63 was detected in an infant in the Netherlands in 2004 and will hereafter be referred to as CoV-NL63. Four years later, it was classified into Group 1 coronaviruses by the International Committee for Taxonomy of Viruses (ICTV), which was modified into alphacoronavirus in …
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Structural and functional studies of the papain-like protease 2 from mouse hepatitis virus
… advantage of ease in culturing in comparison to human coronaviruses.</p> <p>It is reported here the expression and purification of a region of MHV nsp3 that contains the catalytic core of the PLP2 domain and its neighboring domains. More than 20 mg of pure and active protein could be obtained …
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Investigating SARS-CoV-2 immune responses in children
… and pre-exis<ng immunity against endemic human coronaviruses (HCoVs). Notably, a cri<cal role for T cells in controlling COVID-19 severity, has been well documented. The immune mechanisms for the differences in disease progression between children and adults remain to be fully understood …